1H-Benzimidazol-2-amine,N-methyl-(9CI)
- Product Name
- 1H-Benzimidazol-2-amine,N-methyl-(9CI)
- CAS No.
- 17228-38-5
- Chemical Name
- 1H-Benzimidazol-2-amine,N-methyl-(9CI)
- Synonyms
- N-Methyl-1H-benzimidazol-2-amine;1H-BenziMidazol-2-aMine, N-Methyl-;N-Methyl-1H-benzo[d]iMidazol-2-aMine;(1H-Benzoimidazol-2-yl)-methyl-amine;1H-Benzimidazol-2-amine,N-methyl-(9CI)
- CBNumber
- CB11280958
- Molecular Formula
- C8H9N3
- Formula Weight
- 147.18
- MOL File
- 17228-38-5.mol
1H-Benzimidazol-2-amine,N-methyl-(9CI) Property
- Melting point:
- 190-192℃
- Boiling point:
- 313.7±25.0 °C(Predicted)
- Density
- 1.284
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 11.61±0.10(Predicted)
- Appearance
- Off-white to light brown Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M337020
- Product name
- N-Methyl-1H-benzo[d]imidazol-2-amine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M337020
- Product name
- N-Methyl-1H-benzo[d]imidazol-2-amine
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- Z4283
- Product name
- N-Methyl-1H-benzo[d]imidazol-2-amine
- Packaging
- 100mg
- Price
- $111
- Updated
- 2021/12/16
- Product number
- OR917990
- Product name
- N-Methyl-1H-1,3-benzodiazol-2-amine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- Z4283
- Product name
- N-Methyl-1H-benzo[d]imidazol-2-amine
- Packaging
- 1g
- Price
- $234
- Updated
- 2021/12/16
1H-Benzimidazol-2-amine,N-methyl-(9CI) Chemical Properties,Usage,Production
Synthesis
4857-06-1
74-89-5
17228-38-5
N-Methyl-1H-benzo[d]imidazol-2-amine was synthesized as follows: 2-chloro-1H-benzo[d]imidazole (20 g, 131.08 mmol) was placed in an autoclave PV10832 (made of Hastelloy, 450 mL), and methylamine (260 mL, 131.08 mmol) was added and sealed. The reaction mixture was heated to 160°C in an autoclave oven for 16 hours. The pressure in the autoclave reached 11 bar during the reaction. After completion of the reaction, the solvent was removed by distillation under reduced pressure to give a brown oily substance. Ethanol (EtOH) was added to the oil and the solvent was again removed by distillation under reduced pressure to give a brown foamy product. The foamy product was dissolved in a minimal amount of hot acetone and subsequently cooled to room temperature. The precipitated solid was filtered to afford the target product N-methyl-1H-benzo[d]imidazol-2-amine (9.91 g, 51% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 2.83 (3H, s), 6.87-7.00 (2H, m), 7.05-7.25 (2H, m), 7.49 (1H, s).
References
[1] Angewandte Chemie - International Edition, 2012, vol. 51, # 41, p. 10364 - 10367
[2] Tetrahedron Letters, 2016, vol. 57, # 9, p. 1035 - 1039
[3] Patent: US2011/306613, 2011, A1. Location in patent: Page/Page column 29
[4] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1985, p. 1513 - 1522
1H-Benzimidazol-2-amine,N-methyl-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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