3-Pyridinamine,6-(difluoromethoxy)-(9CI)
- Product Name
- 3-Pyridinamine,6-(difluoromethoxy)-(9CI)
- CAS No.
- 317810-73-4
- Chemical Name
- 3-Pyridinamine,6-(difluoromethoxy)-(9CI)
- Synonyms
- 6-(difluoromethoxy)-3-Pyridinamine;3-Amino-6-(difluoromethoxy)pyridine;6-Difluoromethoxy-pyridin-3-ylamine;3-Pyridinamine, 6-(difluoromethoxy)-;3-Pyridinamine,6-(difluoromethoxy)-(9CI)
- CBNumber
- CB11294777
- Molecular Formula
- C6H6F2N2O
- Formula Weight
- 160.12
- MOL File
- 317810-73-4.mol
3-Pyridinamine,6-(difluoromethoxy)-(9CI) Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- liquid
- color
- Clear, dark yelllow
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D590903
- Product name
- 6-(difluoromethoxy)pyridin-3-amine
- Packaging
- 500mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- PC201228
- Product name
- 6-(Difluoromethoxy)pyridin-3-amine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $136
- Updated
- 2021/12/16
- Product number
- 8995BB
- Product name
- 6-(Difluoromethoxy)pyridin-3-amine
- Packaging
- 100mg
- Price
- $172
- Updated
- 2021/12/16
- Product number
- PC201228
- Product name
- 6-(Difluoromethoxy)pyridin-3-amine
- Purity
- 95%
- Packaging
- 1g
- Price
- $340
- Updated
- 2021/12/16
- Product number
- HCH0045454
- Product name
- 6-(DIFLUOROMETHOXY)PYRIDIN-3-AMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.59
- Updated
- 2021/12/16
3-Pyridinamine,6-(difluoromethoxy)-(9CI) Chemical Properties,Usage,Production
Synthesis
1192813-41-4
317810-73-4
Step B: Synthesis of 6-(difluoromethoxy)pyridin-3-amine To degassed methanol (100 mL) was added 2-(difluoromethoxy)-5-nitropyridine (4.7 g, 24.7 mmol) and 10% palladium-carbon catalyst (500 mg, 0.47 mmol). The hydrogenation reaction was carried out at atmospheric pressure for 1 hour. Upon completion of the reaction, acetic acid (2.83 mL, 49.4 mmol) was added, followed by filtration of the reaction mixture through diatomaceous earth and concentration of the filtrate in vacuum to afford 6-(difluoromethoxy)pyridin-3-amine (6.33 g, 25.9 mmol, 105% yield) as an olive green liquid product. 1H NMR (400 MHz, MeOD-d4) δ ppm: 7.60 (d, J = 2.76 Hz, 1H), 7.37 (s, 0.5H), 7.15 (dd, J = 8.66, 2.89 Hz, 1H), 7.00 (s, 0.5H), 6.71 (d, J = 8.78 Hz, 1H).
References
[1] Patent: US2009/270405, 2009, A1. Location in patent: Page/Page column 86
[2] Patent: WO2010/9968, 2010, A1. Location in patent: Page/Page column 44
[3] Patent: WO2011/3684, 2011, A1. Location in patent: Page/Page column 33
[4] Patent: WO2011/53292, 2011, A1. Location in patent: Page/Page column 140
[5] Patent: US2012/108583, 2012, A1. Location in patent: Page/Page column 34