1H-Benzimidazole,5,6-difluoro-(9CI)

Product Name: 1H-Benzimidazole,5,6-difluoro-(9CI)
CAS No.: 78581-99-4
Chemical Name: 1H-Benzimidazole,5,6-difluoro-(9CI)
Synonyms: 1H-Benzimidazole,5,6-difluoro-;5,6-difluoro-1H-benzo[d]iMidazole;1H-Benzimidazole,5,6-difluoro-(9CI)
CBNumber: CB11296216
Molecular Formula: C7H4F2N2
Formula Weight: 154.12
MOL File: 78581-99-4.mol

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1H-Benzimidazole,5,6-difluoro-(9CI) Property

Melting point:: 159-161°
Boiling point:: 369.5±22.0 °C(Predicted)
Density: 1.488±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 11.54±0.30(Predicted)
Appearance: Purple to light brown Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D456233
Product name: 5,6-Difluorobenzimidazole
Packaging: 50mg
Price: $65
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0013405
Product name: 5,6-DIFLUOROBENZIMIDAZOLE
Purity: 95.00%
Packaging: 100MG
Price: $187.95
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-3-4M
Product name: 5,6-Difluorobenzimidazole
Packaging: 250mg
Price: $224
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-3-4M
Product name: 5,6-Difluorobenzimidazole
Packaging: 1g
Price: $426
Updated: 2021/12/16

AK Scientific

Product number: 9743AE
Product name: 5,6-Difluorobenzimidazole
Packaging: 5g
Price: $557
Updated: 2021/12/16

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1H-Benzimidazole,5,6-difluoro-(9CI) Chemical Properties,Usage,Production

Synthesis

64-18-6

76179-40-3

78581-99-4

The general procedure for the synthesis of 5,6-difluorobenzimidazole from 4,5-difluorophthalimide and formic acid was as follows: 4,5-difluorophthalimide (1.5 g, 10 mmol) was dissolved in formic acid (20 mL) and the reaction was heated for 12 hr at 80 °C. Upon completion of the reaction, the mixture was cooled to 25 °C and subsequently concentrated under reduced pressure to remove the solvent. The resulting residue was purified by recrystallization from a solvent mixture of petroleum ether and ethyl acetate (15:1, v/v) to give the final yellow solid 5,6-difluoro-1H-benzo[d]imidazole (1.4 g, 88% yield). Mass spectrum (ESI) m/z: 155 [M + H]+.

References

[1] Patent: WO2015/100609, 2015, A1. Location in patent: Page/Page column 45
[2] Patent: EP2766359, 2016, B1. Location in patent: Paragraph 0756
[3] New Journal of Chemistry, 2006, vol. 30, # 5, p. 803 - 809
[4] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 14, p. 3674 - 3678
[5] ChemCatChem, 2018, vol. 10, # 19, p. 4338 - 4345

1H-Benzimidazole,5,6-difluoro-(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Benzimidazole,5,6-difluoro-(9CI) Suppliers

China 39 Europe 1 India 1 United Kingdom 1 United States 3 Global 45

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78581-99-4, 1H-Benzimidazole,5,6-difluoro-(9CI)Related Search:

1H-Benzimidazole,5,6-difluoro-(9CI)

5,6-difluoro-1H-benzo[d]iMidazole

1H-Benzimidazole,5,6-difluoro-

78581-99-4

BENZIMIDAZOLE