ChemicalBook > CAS DataBase List > 2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-(9CI)

2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-(9CI)

Product Name
2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-(9CI)
CAS No.
233276-38-5
Chemical Name
2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-(9CI)
Synonyms
4-Methyltetrahydro-2H-pyran-4-carboxylic acid;4-Methyltetrahydro-2H-pyr...;4-Methyloxane-4-carboxylic acid;4-Methyltetrahydropyran-4-carboxylic Acid;Tetrahydro-4-methyl-2H-pyran-4-carboxylic acid;2H-Pyran-4-carboxylicacid,tetrahydro-4-Methyl-;2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-(9CI)
CBNumber
CB11298164
Molecular Formula
C7H12O3
Formula Weight
144.17
MOL File
233276-38-5.mol
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2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-(9CI) Property

Boiling point:
257℃
Density 
1.124
Flash point:
105℃
storage temp. 
Sealed in dry,Room Temperature
pka
4.56±0.20(Predicted)
Appearance
White to off-white Solid
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Safety

HS Code 
2932990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M219325
Product name
4-Methyltetrahydro-2H-pyran-4-carboxylicAcid
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
M219325
Product name
4-Methyltetrahydro-2H-pyran-4-carboxylicAcid
Packaging
100mg
Price
$60
Updated
2021/12/16
Ark Pharm
Product number
P000391599
Product name
4-Methyltetrahydro-2H-pyran-4-carboxylic acid
Purity
95+%
Packaging
100mg
Price
$26
Updated
2021/12/16
Ark Pharm
Product number
P000391599
Product name
4-Methyltetrahydro-2H-pyran-4-carboxylic acid
Purity
95+%
Packaging
250mg
Price
$40
Updated
2021/12/16
Ark Pharm
Product number
P000391599
Product name
4-Methyltetrahydro-2H-pyran-4-carboxylic acid
Purity
96+%
Packaging
1g
Price
$94
Updated
2021/12/16
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2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-(9CI) Chemical Properties,Usage,Production

Synthesis

443912-70-7

233276-38-5

The general procedure for the synthesis of 4-methyltetrahydropyran-4-carboxylic acid from methyl 4-methyl-tetrahydro-2H-pyran-4-carboxylate was as follows: to a solution of methyl 4-methyltetrahydro-2H-pyran-4-carboxylate (5.00 g, 31.6 mmol) in a 1:1:1 mixed solvent of dioxane/water/methanol (60 mL), lithium hydroxide hydrate (5.31 g, 126 mmol) and the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was partially concentrated and subsequently diluted with water and ethyl acetate (EtOAc) and acidified with 6 M hydrochloric acid to pH=1. The organic and aqueous layers were separated and the aqueous layer was extracted with additional ethyl acetate (50 mL). All organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated to dryness to afford 4-methyltetrahydro-2H-pyran-4-carboxylic acid (4.61 g, 100% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 12.29 (s, 1H), 3.65 (dt, J=11.8,4.3 Hz, 2H), 3.33-3.32 (m, 2H), 1.87-1.86 (m, 2H), 1.35 (ddd, J=13.5,9.9,4.1 Hz, 2H). 1.13 (s, 3H).

References

[1] Patent: US2014/275016, 2014, A1. Location in patent: Paragraph 0266
[2] Patent: US2014/275080, 2014, A1. Location in patent: Paragraph 0400
[3] ChemMedChem, 2010, vol. 5, # 1, p. 65 - 78

2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-(9CI) manufacturers

Career Henan Chemical Co
Product
2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-(9CI) 233276-38-5
Price
US $1.00/g
Min. Order
100g
Purity
98%min
Supply Ability
G/KG/T
Release date
2019-12-23

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