cyclo(L-leucyl-L-tryptophyl)
- Product Name
- cyclo(L-leucyl-L-tryptophyl)
- CAS No.
- 15136-34-2
- Chemical Name
- cyclo(L-leucyl-L-tryptophyl)
- Synonyms
- Cyclo(Trp-Leu);cyclo-L-Trp-L-Leu;Cyclo(L-Leu-L-Trp);cyclo(L-leucyl-L-tryptophyl);(3S,6S)-3-(1H-indol-3-ylmethyl)-6-(2-methylpropyl)piperazine-2,5-dione;2,5-Piperazinedione, 3-(1H-indol-3-ylmethyl)-6-(2-methylpropyl)-, (3S,6S)-
- CBNumber
- CB11307048
- Molecular Formula
- C17H21N3O2
- Formula Weight
- 299.37
- MOL File
- 15136-34-2.mol
cyclo(L-leucyl-L-tryptophyl) Property
- Boiling point:
- 635.2±45.0 °C(Predicted)
- Density
- 1.182±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Methanol: Soluble
- form
- A solid
- pka
- 13.21±0.60(Predicted)
N-Bromosuccinimide Price
- Product number
- 24942
- Product name
- Cyclo(L-Leu-L-Trp)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $242
- Updated
- 2024/03/01
- Product number
- 24942
- Product name
- Cyclo(L-Leu-L-Trp)
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $846
- Updated
- 2024/03/01
- Product number
- FC108311
- Product name
- Cyclo(-Leu-Trp)
- Packaging
- 2g
- Price
- $949.56
- Updated
- 2021/12/16
- Product number
- FC108311
- Product name
- Cyclo(-Leu-Trp)
- Packaging
- 100mg
- Price
- $91
- Updated
- 2021/12/16
- Product number
- FC108311
- Product name
- Cyclo(-Leu-Trp)
- Packaging
- 250mg
- Price
- $180
- Updated
- 2021/12/16
cyclo(L-leucyl-L-tryptophyl) Chemical Properties,Usage,Production
Description
Cyclo(L-Leu-L-Trp) is a diketopiperazine metabolite originally isolated from Penicillium.1 It is active against various bacteria (MICs = 125-1000 μg/ml) and fungi (MICs = 8-64 μg/ml), and it inhibits the production rate of hydroxy radicals in an electron spin resonance (ESR) spectroscopy-based assay (IC50 = 1.8 μM).2,3 Cyclo(L-Leu-L-Trp) is a bitter tastant that can rapidly permeate rat taste cell membranes ex vivo when used at a concentration of 1 mM.4 It also acts as a melatonin receptor agonist in X. laevis melanophores, inhibiting cAMP accumulation when used at a concentration of 20 μM, an effect that is blocked by the melatonin receptor antagonist luzindole .5
References
1. Solov'eva, T.F., Baskunov, B.P., Nefedova, M.Y., et al. Biosynthesis of leucyl-
2. Kumar, S.N., Mohandas, C., and Nambisan, B. Purification, structural elucidation and bioactivity of tryptophan containing diketopiperazines, from Comamonas testosteroni associated with a rhabditid entomopathogenic nematode against major human-
3. Furukawa, T., Akutagawa, T., Funatani, H., et al. Cyclic dipeptides exhibit potency for scavenging radicals Bioorg. Med. Chem. 20(6),2002-2009(2012).
4. Naim, M., Nir, S., Spielman, A.I., et al. Hypothesis of receptor-
5. Zubare-Samuelov, M., Peri, I., Tal, M., et al. Some sweet and bitter tastants stimulate inhibitory pathway of adenylyl cyclase via melatonin and α2-
cyclo(L-leucyl-L-tryptophyl) Preparation Products And Raw materials
Raw materials
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