9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E,17Z-TRIEN-1-OIC ACID

Product Name: 9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E,17Z-TRIEN-1-OIC ACID
CAS No.: 802-31-3
Chemical Name: 9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E,17Z-TRIEN-1-OIC ACID
Synonyms: PGE3;PROSTAGLANDIN E3;Prostaglandin E3 (PGE3);Prostaglandin E3 Exclusive;9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E,17Z-TRIEN-1-OIC ACID;(5Z,13E,15S,17Z)-11α,15-Dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid;(5Z,11a,13E,15S,17Z) 11,15-dihydroxy-9-oxo-prosta-5,13,17-trien-1-oic acid;Prosta-5,13,17-trien-1-oicacid, 11,15-dihydroxy-9-oxo-, (5Z,11a,13E,15S,17Z)-;Prosta-5,13,17-trien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11α,13E,15S,17Z)-
CBNumber: CB1131385
Molecular Formula: C20H30O5
Formula Weight: 350.45
MOL File: 802-31-3.mol

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9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E,17Z-TRIEN-1-OIC ACID Property

Melting point:: 84.5-85.5 °C
Boiling point:: 541.0±50.0 °C(Predicted)
Density: 1.166±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: >100 mg/ml (from PGE2); DMSO: >100 mg/ml (from PGE2); Ethanol: >100 mg/ml (from PGE2); PBS pH 7.2: >5 mg/ml (from PGE2)
form: Liquid
pka: 4.75±0.10(Predicted)
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 14990
Product name: Prostaglandin E3
Purity: ≥98%
Packaging: 50μg
Price: $141
Updated: 2024/03/01

Cayman Chemical

Product number: 14990
Product name: Prostaglandin E3
Purity: ≥98%
Packaging: 100μg
Price: $267
Updated: 2024/03/01

Cayman Chemical

Product number: 14990
Product name: Prostaglandin E3
Purity: ≥98%
Packaging: 500μg
Price: $1116
Updated: 2024/03/01

Cayman Chemical

Product number: 14990
Product name: Prostaglandin E3
Purity: ≥98%
Packaging: 1mg
Price: $1953
Updated: 2024/03/01

AK Scientific

Product number: 1577AH
Product name: 9-oxo-11alpha,15S-Dihydroxy-prosta-5Z,13E,17Z,trien-1-oicacid
Packaging: 1mg
Price: $2273
Updated: 2021/12/16

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9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E,17Z-TRIEN-1-OIC ACID Chemical Properties,Usage,Production

Uses

Prostaglandin E3 (PGE3) is formed via the cyclooxygenase (COX) metabolism of eicosapentaenoic acid. In human ocular tissue, it comprises 2.4% of the COX products formed. When applied to the eyes of a rabbit, a 1 μg dose of PGE3 decreases intraocular pressure from 21 mmHg to about 17 mmHg.

Definition

ChEBI: Prostaglandin E3 is a prostaglandins E. It has a role as a human metabolite. It is a conjugate acid of a prostaglandin E3(1-).

in vivo

Prostaglandin E3 (1 μmol/L; i.p.) modulates macrophage polarization towards an anti-inflammatory function in LPS (HY-D1056) (5 mg/kg)-induces acute inflammation model^[1].
Prostaglandin E3 (1 μmol/L; every 3 days for 4 weeks) shows anti-tumor activity by regulates macrophage polarization^[1].

Animal Model:	5 weeks, Nude mice (BABL/c) (PC3 xenograft model)^[1]
Dosage:	1 μmol/L for 50 μL
Administration:	Injected next to the tumour, every 3 days for 4 weeks
Result:	Decreased the weights of transplanted tumours, inhibits the expression of CD68 and CD206.

Animal Model:	6-8-week-old C57BL6/J mice^[1]
Dosage:	LPS+ PGE3 (5 mg/kg + 1 μmol/L)
Administration:	I.p.; once
Result:	Significantly reduced MPMs with an M1-like phenotype and increased M2-like MPMs, inhibited inflammatory cytokine secretion in both the serum and MPM cell lysates.

9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E,17Z-TRIEN-1-OIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E,17Z-TRIEN-1-OIC ACID Suppliers

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802-31-3, 9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E,17Z-TRIEN-1-OIC ACIDRelated Search:

CIS-5-DODECENOIC ACID 1,5-HEPTADIEN-4-OL 1-BUTENYLCYCLOPENTANE ALLYLCYCLOPENTANE 9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E,17Z-TRIEN-1-OIC ACID

9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E,17Z-TRIEN-1-OIC ACID

PROSTAGLANDIN E3

(5Z,11a,13E,15S,17Z) 11,15-dihydroxy-9-oxo-prosta-5,13,17-trien-1-oic acid

(5Z,13E,15S,17Z)-11α,15-Dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid

PGE3

Prostaglandin E3 Exclusive

Prosta-5,13,17-trien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11α,13E,15S,17Z)-

Prosta-5,13,17-trien-1-oicacid, 11,15-dihydroxy-9-oxo-, (5Z,11a,13E,15S,17Z)-

Prostaglandin E3 (PGE3)

802-31-3