8-BROMOADENINE
- Product Name
- 8-BROMOADENINE
- CAS No.
- 6974-78-3
- Chemical Name
- 8-BROMOADENINE
- Synonyms
- AKOS NCG1-0087;8-BROMOADENINE;8-Brom-1H-adenin;8-bromo-1H-adenine;6-Amino-8-bromopurine;8-BroMo-7H-purin-6-aMine;8-bromo-9H-purin-6-amine;8-Bromo-1H-purin-6-amine;8-BROMOADENINE USP/EP/BP;6-Amino-8-bromo-9H-purine
- CBNumber
- CB1131491
- Molecular Formula
- C5H4BrN5
- Formula Weight
- 214.02
- MOL File
- 6974-78-3.mol
8-BROMOADENINE Property
- Melting point:
- >250℃
- Boiling point:
- 287.4±50.0 °C(Predicted)
- Density
- 2.54±0.1 g/cm3(Predicted)
- RTECS
- UO7410000
- solubility
- DMSO (Slightly, Heated, Sonicated), Methanol (Slightly)
- form
- Powder
- pka
- 6.28±0.20(Predicted)
- color
- White to Pale Brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B679370
- Product name
- 8-Bromoadenine
- Packaging
- 0.5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- B679370
- Product name
- 8-Bromoadenine
- Packaging
- 5g
- Price
- $265
- Updated
- 2021/12/16
- Product number
- FB08273
- Product name
- 8-Bromoadenine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FB08273
- Product name
- 8-Bromoadenine
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 063686
- Product name
- 8-Bromo-9H-purin-6-amine
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
8-BROMOADENINE Chemical Properties,Usage,Production
Uses
8-Bromoadenine injected into mice before exposure to irradiation increased the radiosensitivity of bone marrow hemopoietic stem cells.
Synthesis
66224-66-6
6974-78-3
Adenine (40 g) was used as starting material, which was placed in a flask and liquid bromine (107 mL) was slowly added under mechanical stirring. After addition, the reaction was continued with stirring for 3 hours at room temperature. Upon completion of the reaction, excess liquid bromine was removed by addition of sodium bisulfite solution. Subsequently, the reaction solution was adjusted to neutral with ammonia, at which time a white powdery solid precipitated. A filtration operation was carried out and the resulting solid was washed with ice water to give 8-bromoadenine as a pale yellow solid (54 g) in 85.7% yield.
References
[1] Patent: CN108503643, 2018, A. Location in patent: Paragraph 0023; 0036; 0037; 0038
[2] Patent: US2008/234297, 2008, A1. Location in patent: Page/Page column 33; 38
[3] Synthetic Communications, 2013, vol. 43, # 11, p. 1469 - 1476
[4] Journal of Medicinal Chemistry, 2009, vol. 52, # 19, p. 5974 - 5989
[5] Collection of Czechoslovak Chemical Communications, 2000, vol. 65, # 7, p. 1126 - 1144
8-BROMOADENINE Preparation Products And Raw materials
Raw materials
Preparation Products
8-BROMOADENINE Suppliers
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- United Kingdom
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- United Kingdom
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View Lastest Price from 8-BROMOADENINE manufacturers
- Product
- 8-Bromoadenine 6974-78-3
- Price
- US $2500.00/g
- Min. Order
- 1g
- Purity
- 98
- Supply Ability
- 500 Kg
- Release date
- 2024-04-11