bafilomycin D
- Product Name
- bafilomycin D
- CAS No.
- 98813-13-9
- Chemical Name
- bafilomycin D
- Synonyms
- bafilomycin D;TubayMycin, 3D5;Bafilomycin D, from Streptomyces griseus;Oxacyclohexadeca-3,5,11,13-tetraen-2-one, 16-[(1S,2R,3S,5E,7S,8R)-2,8-dihydroxy-1,3,7,9-tetramethyl-4-oxo-5-decen-1-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-, (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-
- CBNumber
- CB11315335
- Molecular Formula
- C35H56O8
- Formula Weight
- 604.81
- MOL File
- 98813-13-9.mol
bafilomycin D Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in ethanol;Soluble in methanol;Soluble in DMSO
- form
- powder
N-Bromosuccinimide Price
- Product number
- 19438
- Product name
- Bafilomycin D
- Purity
- ≥99%
- Packaging
- 1mg
- Price
- $364
- Updated
- 2024/03/01
- Product number
- 19438
- Product name
- Bafilomycin D
- Purity
- ≥99%
- Packaging
- 5mg
- Price
- $1181
- Updated
- 2024/03/01
- Product number
- B110008
- Product name
- BafilomycinD
- Packaging
- 5mg
- Price
- $8350
- Updated
- 2021/12/16
- Product number
- B0003-73
- Product name
- Bafilomycin D
- Packaging
- 1mg
- Price
- $523
- Updated
- 2021/12/16
- Product number
- BVT-0475-M001
- Product name
- BafilomycinD(highpurity)
- Purity
- ≥98%(HPLC)
- Packaging
- 1mg
- Price
- $180
- Updated
- 2021/12/16
bafilomycin D Chemical Properties,Usage,Production
Uses
Bafilomycin D is a member of a potent family of macrocyclic lactones. Bafilomycin D shares the same mode of action as bafilomycin A1 which has been the analogue of choice in cell biology studies of the role of ATPase. Bafilomycin D contains the ring-opened side chain and is a much more stable analogue of bafilomycin A1. Limited availability has restricted a more in depth investigation of this metabolite.
Uses
The bafilomycins are fungal plecomacrolide antibiotics with a 16-membered lactone ring. They inhibit the growth of Gram-positive bacteria and fungi. Bafilomycin D is a potent inhibitor of vacuolar H+ ATPases (V-ATPases) that inhibits the V-ATPase from the fungus N. crassa with an IC50 value of approximately 2 nM. It is about 1,000-fold less effective against the K+-dependent ATPase of E. coli.
Biological Activity
bafilomycin d is a potent inhibitor of vacuolar h+ atpases (v-atpases) with ic50 value of approximately 2 nm for the v-atpase from the fungus n. crassa [1].ion pumps use the energy provided by the hydrolysis of atp to energize ion-transport processes across cell membranes. atpases can be distinguished to p-type, f-type and v-type atpases. p-type atpases have a phosphorylated transitional stage, f-type atpases are primarily used in atp synthesis, and v-type atpases are genetically and functionally related to f-atpases but function only in atp breakdown [1].the bafilomycins are fungal plecomacrolide class macrolide antibiotics isolated from the culture medium of streptomyces sp. and are also high-affinity inhibitors of v-atpases and can be used to study specifically the function of this type of atpase. they inhibited the growth of gram-positive bacteria and fungi. bafilomycin c1 inhibited the enzymatic activity of the na+, k+-atpase with ki value of 11 μmol/l and showed anthelmintic activity against caenorhabditis elegans [1][2].
References
[1]. drse s, altendorf k. bafilomycins and concanamycins as inhibitors of v-atpases and p-atpases. j exp biol. 1997 jan;200(pt 1):1-8.
[2]. bowman ej, siebers a, altendorf k. bafilomycins: a class of inhibitors of membrane atpases from microorganisms, animal cells, and plant cells. proc natl acad sci u s a. 1988 nov;85(21):7972-6.
bafilomycin D Preparation Products And Raw materials
Raw materials
Preparation Products
bafilomycin D Suppliers
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- 86-(0)29-85992781 17792393971
- info@lynnchem.com
- Country
- China
- ProdList
- 4587
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57412
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11217
- Advantage
- 58
- Tel
- 400-820-6829
- sales@mitachieve.com
- Country
- China
- ProdList
- 8860
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 0513-68819626; 15152877458
- Fax
- 0513-68669626
- feiyubio@163.com
- Country
- China
- ProdList
- 4819
- Advantage
- 58
- Tel
- 021-58000709 15900491054
- info@scrbio.com
- Country
- China
- ProdList
- 10329
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12005
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@wheybio.com
- Country
- CHINA
- ProdList
- 4398
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@f-biology.com
- Country
- CHINA
- ProdList
- 6025
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenxue_gz@163.com
- Country
- CHINA
- ProdList
- 6600
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1310057982@qq.com
- Country
- CHINA
- ProdList
- 790
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1985563437@qq.com
- Country
- CHINA
- ProdList
- 6158
- Advantage
- 58
- Tel
- --
- Fax
- --
- marketing@4abio.com
- Country
- CHINA
- ProdList
- 6401
- Advantage
- 58
- Tel
- --
- Fax
- --
- lyn@biopike.com.cn
- Country
- CHINA
- ProdList
- 6629
- Advantage
- 58
- Tel
- --
- Fax
- --
- market@xlswkj.com
- Country
- CHINA
- ProdList
- 6793
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenjw@absin.cn
- Country
- CHINA
- ProdList
- 6654
- Advantage
- 58
- Tel
- --
- Fax
- --
- shxiyuanbio@163.com
- Country
- CHINA
- ProdList
- 6906
- Advantage
- 58
- Tel
- --
- Fax
- --
- 15810802415@139.com
- Country
- CHINA
- ProdList
- 6750
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1861586486@qq.com
- Country
- CHINA
- ProdList
- 6648
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58