BIBS 39

Product Name: BIBS 39
CAS No.: 133085-33-3
Chemical Name: BIBS 39
Synonyms: CS-2534;BIBS 39;BIBS 39; BIBS-39;2-[4-[[2-butyl-6-(cyclohexylcarbamoylamino)benzimidazol-1-yl]methyl]phenyl]benzoic acid;4'-((2-butyl-6-(3-cyclohexylureido)-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid;4'-({2-butyl-6-[(cyclohexylcarbamoyl)amino]-1H-1,3-benzodiazol-1-yl}methyl)-[1,1'-biphenyl]-2-carboxylic acid;[1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-butyl-6-[[(cyclohexylamino)carbonyl]amino]-1H-benzimidazol-1-yl]methyl]-
CBNumber: CB11322261
Molecular Formula: C32H36N4O3
Formula Weight: 524.65
MOL File: 133085-33-3.mol

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BIBS 39 Property

Boiling point:: 729.1±60.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF:30.0(Max Conc. mg/mL);57.18(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);57.18(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.48(Max Conc. mM)
form: A crystalline solid
pka: 3.84±0.36(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22932
Product name: BIBS39
Packaging: 1mg
Price: $29
Updated: 2024/03/01

Cayman Chemical

Product number: 22932
Product name: BIBS39
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 22932
Product name: BIBS39
Packaging: 10mg
Price: $143
Updated: 2024/03/01

Cayman Chemical

Product number: 22932
Product name: BIBS39
Packaging: 25mg
Price: $250
Updated: 2024/03/01

AK Scientific

Product number: 9194CA
Product name: 2-[4-[[2-Butyl-6-(cyclohexylcarbamoylamino)benzimidazol-1-yl]methyl]phenyl]benzoicacid
Packaging: 1mg
Price: $148
Updated: 2021/12/16

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BIBS 39 Chemical Properties,Usage,Production

Uses

BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist. Target: Angiotensin Receptor in vitro: BIBS 39 displaces [125I] AII from its specific binding sites with a Ki value of 29 ± 7 nM for the AII subtype 1 (AT1) receptor and a Ki value of 480 ± 110 nM for the AII subtype 2 (AT2) receptor. BIBS 222 shows a Ki value of 20 ± 7 nM for the AT1 subtype and a Ki value of 730 ± 170 nM for the AT2 subtype. BIBS 39 is 17 times more selective for the AT1 subtype and BIBS 222 37 times. BIBS 39 shifts the AII concentration-contractile response curves in isolated rabbit aorta to the right in a parallel fashion. [1] in vivo: In pithed rats, BIBS 39 dependently shifts the dose-response curve of AII to the right without affecting the maximal response. BIBS 222 also causes parallel shifts to the right but a significant reduction of the maximal responses was observed at 3 and 10 mg/kg i.v. These results show that the benzimidazole derivatives BIBS 39 is a potent and selective AII receptor antagonists. Substitution with a benzimidazole moiety results into a considerable loss of selectivity for the AT1 receptor subtype compared with an imidazole moiety as, for instance, in DuP 753.[1] BIBS 39 is a new nonpeptide angiotensin receptor blockers that has affinity for both AT1- and AT2-receptors, is also a potent antagonist of the cardiovascular effects of AII in pithed rabbits. [2]

IC 50

AT2 Receptor; AT1 Receptor

References

[1] Zhang J, et al. Characterization of BIBS 39 and BIBS 222: two new nonpeptide angiotensin II receptor antagonists. Eur J Pharmacol. 1992 Jul 21;218(1):35-41. DOI:10.1016/0014-2999(92)90144-s
[2] Zhang J, et al. Hemodynamic effects of angiotensin II and the influence of angiotensin receptor antagonists in pithed rabbits. J Cardiovasc Pharmacol. 1995 May;25(5):724-31. DOI:10.1097/00005344-199505000-00007

BIBS 39 Preparation Products And Raw materials

Raw materials

Preparation Products

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BIBS 39 Suppliers

China 38 South Korea 1 United States 9 Global 48

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View Lastest Price from BIBS 39 manufacturers

Career Henan Chemical Co

Product: 2-[4-[[2-butyl-6-(cyclohexylcarbamoylamino)benzimidazol-1-yl]methyl]phenyl]benzoic acid 133085-33-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

133085-33-3, BIBS 39Related Search:

1H-Benzimidazol-6-amine,2-ethyl-1-methyl- 1-PHENYL-1H-BENZOIMIDAZOLE 1-[1,1''-BIPHENYL]-4-YL-1H-IMIDAZOLE 2-METHYL-1-PHENYL-1H-BENZOIMIDAZOLE BIBS 39 1H-Benzimidazole,1-methyl-2-propyl-(9CI)

BIBS 39

CS-2534

BIBS 39; BIBS-39

2-[4-[[2-butyl-6-(cyclohexylcarbamoylamino)benzimidazol-1-yl]methyl]phenyl]benzoic acid

[1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-butyl-6-[[(cyclohexylamino)carbonyl]amino]-1H-benzimidazol-1-yl]methyl]-

4'-({2-butyl-6-[(cyclohexylcarbamoyl)amino]-1H-1,3-benzodiazol-1-yl}methyl)-[1,1'-biphenyl]-2-carboxylic acid

4'-((2-butyl-6-(3-cyclohexylureido)-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid

133085-33-3

C32H36N4O3