ChemicalBook > CAS DataBase List > 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole

2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole

Product Name
2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
CAS No.
150493-34-8
Chemical Name
2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
Synonyms
NS 638;NS638, >98%;NS-638;NS 638;2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole;1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine;1-[(4-Chlorophenyl)Methyl]-5-(Trifluoromethyl)Benzimidazol-2-Amine;1H-Benzimidazol-2-amine,1-[(4-chlorophenyl)methyl]-5-(trifluoromethyl)-;Ca channels,Inhibitor,NS-638,Calcium Channel,inhibit,Ca2+ channels,NS638;1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine[NS638
CBNumber
CB11344812
Molecular Formula
C15H11ClF3N3
Formula Weight
325.72
MOL File
150493-34-8.mol
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2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole Property

Boiling point:
476.3±55.0 °C(Predicted)
Density 
1.45±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol
form 
A solid
pka
5.15±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-6337
Product name
NS-638
Purity
>98.0%
Packaging
2mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-6337
Product name
NS-638
Purity
>98.0%
Packaging
5mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-6337
Product name
NS-638
Purity
>98.0%
Packaging
10mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-6337
Product name
NS-638
Purity
>98.0%
Packaging
25mg
Price
$290
Updated
2021/12/16
ChemScene
Product number
CS-6337
Product name
NS-638
Purity
>98.0%
Packaging
50mg
Price
$470
Updated
2021/12/16
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2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole Chemical Properties,Usage,Production

Biological Activity

NS-638 is a non-peptidic small molecule with Ca2+-ion channel blocking properties. The IC50 value for intracellular blocking of the increase in Ca2+ concentration activated by K+ was 3.4 μM.

in vivo

In the mouse middle cerebral artery occlusion model, NS-638 administered ip (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days, results in a 48% reduction in total infarct volume. It does not show protection against ischemic neuronal damage in the gerbil model of bilateral carotid artery occlusion.

target

IC50: 3.4 μM (K + -stimulated intracellular Ca 2+ -elevation)

2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole Suppliers

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150493-34-8, 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazoleRelated Search:

NS 1619 Selexipag NS 11394 NS-6180 1-METHYL-5-TRIFLUOROMETHYLBENZIMIDAZOLE 5-METHYL-1H-BENZIMIDAZOL-2-AMINE 5-TRIFLUOROMETHYL-1H-BENZIMIDAZOLE 1-BENZYL-1H-BENZOIMIDAZOL-2-YLAMINE 1-BENZYL-1H-IMIDAZOL-2-YLAMINE 5-TRIFLUOROMETHYL-1H-BENZOIMIDAZOL-2-YLAMINE 1-(4-Chlorophenylmethyl)-2-aminobenzimidazole 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole

  • 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
  • NS 638
  • 1H-Benzimidazol-2-amine,1-[(4-chlorophenyl)methyl]-5-(trifluoromethyl)-
  • 1-[(4-Chlorophenyl)Methyl]-5-(Trifluoromethyl)Benzimidazol-2-Amine
  • NS-638;NS 638
  • NS638, >98%
  • 1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine
  • 1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine[NS638
  • Ca channels,Inhibitor,NS-638,Calcium Channel,inhibit,Ca2+ channels,NS638
  • 150493-34-8