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3-HYDRAZINO-QUINOXALINE-2-THIOL

Product Name
3-HYDRAZINO-QUINOXALINE-2-THIOL
CAS No.
13080-21-2
Chemical Name
3-HYDRAZINO-QUINOXALINE-2-THIOL
Synonyms
AKOS BBS-00008251;CHEMBRDG-BB 5215319;3-Hydrazinylquinoxaline-2-thiol;3-HYDRAZINO-QUINOXALINE-2-THIOL;3-Hydrazinylquinoxaline-2(1H)-thione;2(1H)-Quinoxalinethione, 3-hydrazinyl-;3-hydrazinoquinoxaline-2-thiol(SALTDATA: FREE);membranes,Helicobacter,ulcer,Antimicrobial,gastric,HPi1,inhibit,Inhibitor,Bacterial,permeate,HPi 1,HPi-1,orally,pylori,peptic
CBNumber
CB1135666
Molecular Formula
C8H8N4S
Formula Weight
192.24
MOL File
13080-21-2.mol
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3-HYDRAZINO-QUINOXALINE-2-THIOL Property

Melting point:
254 °C (decomp)(Solv: ethanol (64-17-5))
Boiling point:
376.1±25.0 °C(Predicted)
Density 
1.55±0.1 g/cm3(Predicted)
pka
7.91±0.20(Predicted)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H370Causes damage to organs

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
H954603
Product name
3-Hydrazinylquinoxaline-2-thiol
Packaging
250mg
Price
$310
Updated
2021/12/16
ChemScene
Product number
CS-0078290
Product name
HPi1
Purity
≥98.0%
Packaging
5mg
Price
$320
Updated
2021/12/16
AK Scientific
Product number
6386CD
Product name
3-Hydrazinoquinoxaline-2-thiol
Packaging
500mg
Price
$386
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0984007
Product name
3-HYDRAZINO-2-QUINOXALINETHIOL
Purity
95.00%
Packaging
5MG
Price
$496.43
Updated
2021/12/16
ChemBridge Corporation
Product number
BB-5215319
Product name
3-hydrazinoquinoxaline-2-thiol
Purity
95%
Packaging
1g
Price
$235
Updated
2021/12/16
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3-HYDRAZINO-QUINOXALINE-2-THIOL Chemical Properties,Usage,Production

Uses

HPi1 is a potent, selective and orally active antimicrobial against Helicobacter pylori with an IC50 of 0.24 μM and an MIC of 0.08-0.16 μg/mL. HPi1 is inactive against other bacteria, including the gut commensals Lactobacillus casei, Lactobacillus reuteri, and Bifidobacterium longum[1].

Biological Activity

HPi1 is a potent, selective and orally active antibacterial agent against Helicobacter pylori with IC50 of 0.24 μM and MIC of 0.08-0.16 μg/mL. It is inactive against other bacteria, including the enteric bacteria Lactobacillus casei, Lactobacillus reuteri and Bifidobacterium longum.

in vitro

The MIC against H. pylori isolates ranged from 0.002-0.032 μg/mL (0.01-0.17 μM) in the agar dilution assay. HPi1 is effective against the clarithromycin-resistant strains ARHp172 (MIC of 0.004–0.016 μg/mL) and ARHp246 (MIC of 0.008–0.032 μg/mL).
HPi1 has some activity against the Bacteroides species , but at concentrations at least 18- fold higher than the H. pylori MIC. More potent activity is detected for Campylobacter jejuni with an MIC of 0.3 μg/mL.
HPi1 has good physicochemical and pharmacological properties, including determining the aqueous solubility (19 μg/mL), human plasma protein binding (93% bound), stability with human liver microsomes (T 1/2 of 1.3 hours) and the ability to passively permeate membranes.

in vivo

HPi1 (6.25-50 mg/kg; Oral gavage; once a day; for 3 days; female C57BL/6 mice) treatment decreases colony counts below the limit of detection at doses of 25 or 50 mg/kg/day[1].

Animal Model:Adult specific-pathogen-free female C57BL/6 mice (6-8-week-old) fed with H. pylori SS1 suspension[1]
Dosage:6.25 mg/kg, 12.5 mg/kg, 25 mg/kg, 50 mg/kg
Administration:Oral gavage; once a day; for 3 days
Result:Reduced colony counts to below the limit of detection.

target

IC50: 0.24 μM ( Helicobacter pylori )
MIC: 0.08-0.16 μg/mL ( Helicobacter pylori )

References

[1] Gavrish E, et al. In vitro and in vivo activities of HPi1, a selective antimicrobial against Helicobacter pylori. Antimicrob Agents Chemother. 2014 Jun;58(6):3255-60. DOI:10.1128/AAC.02573-13

3-HYDRAZINO-QUINOXALINE-2-THIOL Preparation Products And Raw materials

Raw materials

Preparation Products

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3-HYDRAZINO-QUINOXALINE-2-THIOL Suppliers

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13080-21-2, 3-HYDRAZINO-QUINOXALINE-2-THIOLRelated Search:

2-Hydrazinopyrazine AURORA 13895 3-HYDRAZINO-QUINOXALINE-2-THIOL 2-HYDRAZINOQUINOXALINE AURORA 13994

  • CHEMBRDG-BB 5215319
  • AKOS BBS-00008251
  • 3-HYDRAZINO-QUINOXALINE-2-THIOL
  • 3-hydrazinoquinoxaline-2-thiol(SALTDATA: FREE)
  • 2(1H)-Quinoxalinethione, 3-hydrazinyl-
  • 3-Hydrazinylquinoxaline-2-thiol
  • 3-Hydrazinylquinoxaline-2(1H)-thione
  • membranes,Helicobacter,ulcer,Antimicrobial,gastric,HPi1,inhibit,Inhibitor,Bacterial,permeate,HPi 1,HPi-1,orally,pylori,peptic
  • 13080-21-2