ChemicalBook > CAS DataBase List > 2-(4-FLUORO-PHENYL)-PIPERAZINE

2-(4-FLUORO-PHENYL)-PIPERAZINE

Product Name
2-(4-FLUORO-PHENYL)-PIPERAZINE
CAS No.
65709-33-3
Chemical Name
2-(4-FLUORO-PHENYL)-PIPERAZINE
Synonyms
2-(4-FLUORO-PHENYL)-PIPERAZINE;2-(4-Fluorophenyl)piperazine95%;Piperazine, 2-(4-fluorophenyl)-;2-(4-fluorophenyl)piperazine-1,4-diium;2-(4-FLUORO-PHENYL)-PIPERAZINE ISO 9001：2015 REACH
CBNumber
CB1135671
Molecular Formula
C10H13FN2
Formula Weight
180.22
MOL File
65709-33-3.mol
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2-(4-FLUORO-PHENYL)-PIPERAZINE Property

Melting point:
111-114°C
Boiling point:
287.2±35.0 °C(Predicted)
Density 
1.079±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF: 30 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
form 
A crystalline solid
pka
8.76±0.40(Predicted)
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24421
Product name
2-(4-Fluorophenyl)piperazine
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
24421
Product name
2-(4-Fluorophenyl)piperazine
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Oakwood
Product number
024816
Product name
2-(4-Fluorophenyl)piperazine
Purity
94%
Packaging
250mg
Price
$50
Updated
2021/12/16
Apolloscientific
Product number
PC902756
Product name
2-(4-Fluorophenyl)piperazine
Purity
95%
Packaging
250mg
Price
$100
Updated
2021/12/16
Oakwood
Product number
024816
Product name
2-(4-Fluorophenyl)piperazine
Purity
94%
Packaging
1g
Price
$100
Updated
2021/12/16
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2-(4-FLUORO-PHENYL)-PIPERAZINE Chemical Properties,Usage,Production

Description

2-(4-Fluorophenyl)piperazine (Item No. 24421) is an analytical reference standard categorized as a piperazine. This product is intended for research and forensic applications.WARNING This product is not for human or veterinary use.

Synthesis

403-32-7

107-15-3

65709-33-3

An ethanol (100 mL) solution of ethylenediamine (7.4 g, 123.5 mmol) was added dropwise to a stirred ethanol (300 mL) solution of 4-fluorobenzoylcarboxaldehyde (21.0 g, 123.5 mmol) over 15 minutes, keeping the reaction mixture stirred. The reaction lasted for 4 hours. Sodium borohydride (23.5 g, 622 mmol) was then added and the mixture was stirred at room temperature overnight. Water (200 mL) was added and stirring was continued for 1 hour, after which most of the ethanol was removed under reduced pressure. The concentrated solution was extracted with dichloromethane (4 x 100 mL) and the organic phases were combined, washed with brine and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give a light yellow solid (19.0 g, 86% yield). The solid (8.8 g) was dissolved in methanol (60 mL) and added to a solution of N-acetyl-L-leucine (16.5 g, 95.2 mmol) in methanol (100 mL). Ethyl acetate (550 mL) was added and the mixture was allowed to stand overnight at room temperature. The precipitate was collected by filtration and dried to give a solid (9.0 g). The solid was dissolved in 4 M NaOH aqueous solution (100 mL) and extracted with dichloromethane (4 x 100 mL). The organic phases were combined, washed with brine and the solvent was removed under reduced pressure to give a solid (3.1 g). The solid was recrystallized by ethyl acetate to give the S-enantiomer 2-(4-fluorophenyl)-piperazine (2.23 g). The enantiomeric excess was determined by chiral chromatography under the following conditions: column: Phenomenex Chirex (S)-ICR 250×4.6 mm; mobile phase: n-heptane:ethanol [80:20] + 0.3% TFA; detection wavelength: 254 nm; flow rate: 1 mL/min; UV sensitivity: 0.1 AUF. The sample was analyzed using known chiral compounds and the racemate as reference. racemate as reference, the sample was dissolved in 1 mL of n-heptane:ethanol [75:25] at a concentration of about 1 mg/mL.

References

[1] Patent: WO2006/86705, 2006, A1. Location in patent: Page/Page column 58

2-(4-FLUORO-PHENYL)-PIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-FLUORO-PHENYL)-PIPERAZINE Suppliers

China 46 Germany 2 Hungary 1 India 2 United Kingdom 3 United States 12 Global 66
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Wuhan Chemwish Technology Co., Ltd
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86-027-67849912
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86-027-87531808
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sales@chemwish.com
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China
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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
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+86-21-54098501
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+86-21-54096319
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sales@sinch.com.cn
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China
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Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
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sales@chemreagents.com
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United States
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NovoChemy Ltd.
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021-31261262/ 49 (0)17662837245
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(0)21-33250524
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Germany
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Shanghai Topbiochem Technology Co., Ltd
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info@topbiochem.com
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China
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Amatek Scientific Co. Ltd.
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Nantong MYBio-pharm. Co., Ltd.
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0513-85921823 18662920231
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86-513-85012876
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sales@ntminyanmedical.com
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China
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Cool Pharm, Ltd
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021-60455363 18019463053
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50966098
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Amadis Chemical Company Limited
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0086-571-89925065
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sales@amadischem.com
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View Lastest Price from 2-(4-FLUORO-PHENYL)-PIPERAZINE manufacturers

Dideu Industries Group Limited
Product
2-(4-FLUORO-PHENYL)-PIPERAZINE 65709-33-3
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons
Release date
2022-02-23
Career Henan Chemical Co
Product
2-(4-FLUORO-PHENYL)-PIPERAZINE 65709-33-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
KG/T
Release date
2019-12-19

65709-33-3, 2-(4-FLUORO-PHENYL)-PIPERAZINERelated Search:

3-(3,4-DIFLUORO-PHENYL)-PIPERAZIN-2-ONE 2-(3,4-DIFLUORO-PHENYL)-PIPERAZINE (S)-2-(4-FLUORO-PHENYL)-PIPERAZINE 2-(4-FLUORO-PHENYL)-PIPERAZINE 3-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE 3-[4-(4-FLUORO-PHENYL)-PIPERAZINE-1-SULFONYL]-BENZOIC ACID 2-(2-FLUORO-PHENYL)-PIPERAZINE 1-[(4-ETHYLSULFONYL-2-FLUORO)PHENYL]PIPERAZINE 3-(3-FLUORO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 2-(3-FLUORO-PHENYL)-PIPERAZINE 2-(2,4-DIFLUORO-PHENYL)-PIPERAZINE 3-(4-FLUORO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-2-(2,4-DIFLUORO-PHENYL)-PIPERAZINE (S)-2-(2,4-DIFLUORO-PHENYL)-PIPERAZINE (S)-2-(3,4-DIFLUORO-PHENYL)-PIPERAZINE (R)-2-(4-FLUORO-PHENYL)-PIPERAZINE (R)-3-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE (R)-3-(3,4-DIFLUORO-PHENYL)-PIPERAZIN-2-ONE

  • 2-(4-Fluorophenyl)piperazine95%
  • 2-(4-FLUORO-PHENYL)-PIPERAZINE
  • 2-(4-fluorophenyl)piperazine-1,4-diium
  • Piperazine, 2-(4-fluorophenyl)-
  • 2-(4-FLUORO-PHENYL)-PIPERAZINE ISO 9001：2015 REACH
  • 65709-33-3
  • pharmacetical
  • API intermediates