conantokin R
- Product Name
- conantokin R
- CAS No.
- 202925-60-8
- Chemical Name
- conantokin R
- Synonyms
- conantokin R;PubChem ID: 90488802;L-Proline, glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-valyl-L-alanyl-L-lysyl-L-methionyl-L-alanyl-L-alanyl-4-carboxy-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl-4-carboxy-L-α-glutamyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-asparaginyl-L-c...;L-Proline, glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-valyl-L-alanyl-L-lysyl-L-methionyl-L-alanyl-L-alanyl-4-carboxy-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl-4-carboxy-L-α-glutamyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-asparaginyl-L-cysteinyl-L-tyrosyl-, cyclic (21→25)-disulfide
- CBNumber
- CB11367596
- Molecular Formula
- C127H201N35O49S3
- Formula Weight
- 3098.36
- MOL File
- 202925-60-8.mol
conantokin R Property
- Density
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- Sequence
- Gly-Glu-{Gla}-{Gla}-Val-Ala-Lys-Met-Ala-Ala-{Gla}-Leu-Ala-Arg-{Gla}-Asn-Ile-Ala-Lys-Gly-Cys-Lys-Val-Asn-Cys-Tyr-Pro (Disulfide bridge:Cys21-Cys25)
N-Bromosuccinimide Price
- Product number
- PEP0004466
- Product name
- CONANTOKIN-R
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.45
- Updated
- 2021/12/16
conantokin R Chemical Properties,Usage,Production
Description
Potent, non-competitive NMDA receptor antagonist (IC50= 93 nM) that has been suggested to have NR2 subunit selectivity. Inhibits inward currents evoked by NMDA in central nervous system neurons (IC50= 350 nM) and exhibits broad anticonvulsant and antiparkinsonian activityin vivoat doses devoid of behavioral toxicity.
Uses
Conantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC50 of 93 nM. Conantokin R binds Zn2+ and Mg2+ with Kds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity[1][2].
References
[1] Blandl T, et al. Structure-function relationships of the NMDA receptor antagonist peptide, conantokin-R. FEBS Lett. 2000 Mar 24;470(2):139-46. DOI:10.1016/s0014-5793(00)01309-0
[2] White HS, et al. In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. J Pharmacol Exp Ther. 2000 Jan;292(1):425-32. PMID:10604979