ChemicalBook > CAS DataBase List > 8-Hydroxyquinoline-2-carboxaldehyde

8-Hydroxyquinoline-2-carboxaldehyde

Product Name
8-Hydroxyquinoline-2-carboxaldehyde
CAS No.
14510-06-6
Chemical Name
8-Hydroxyquinoline-2-carboxaldehyde
Synonyms
AKOS BBS-00000128;8-hydroxyquinaldaldehyde;Quinaldaldehyde, 8-hydroxy-;8-Hydroxy-2-quinolinecarbaldehyde;8-HYDROXY-QUINOLINE-2-CARBALDEHYDE;8-Hydroxy-2-quinolinecarboxaldehyde;8-HYDROXYQUINOLINE-2-CARBOXALDEHYDE;2-Quinolinecarboxaldehyde, 8-hydroxy-;8-HYDROXYQUINOLINE-2-CARBOXALDEHYDE 98%;8-Hydroxyquinoline-2-carboxaldehyde ,98%
CBNumber
CB1136870
Molecular Formula
C10H7NO2
Formula Weight
173.17
MOL File
14510-06-6.mol
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8-Hydroxyquinoline-2-carboxaldehyde Property

Melting point:
97-100 °C
Boiling point:
392.2±22.0 °C(Predicted)
Density 
1.364±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
9.27±0.10(Predicted)
form 
Crystalline Powder
color 
Yellow
BRN 
127519
InChI
InChI=1S/C10H7NO2/c12-6-8-5-4-7-2-1-3-9(13)10(7)11-8/h1-6,13H
InChIKey
SLBPIHCMXPQAIQ-UHFFFAOYSA-N
SMILES
N1C2C(=CC=CC=2O)C=CC=1C=O
CAS DataBase Reference
14510-06-6
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
55083
Product name
8-Hydroxy-2-quinolinecarboxaldehyde
Purity
≥98.0% (GC)
Packaging
1g
Price
$80.4
Updated
2025/07/31
Sigma-Aldrich
Product number
55083
Product name
8-Hydroxy-2-quinolinecarboxaldehyde
Purity
≥98.0% (GC)
Packaging
5G
Price
$326
Updated
2025/07/31
TCI Chemical
Product number
H1713
Product name
8-Hydroxyquinoline-2-carbaldehyde
Packaging
200MG
Price
$24
Updated
2025/07/31
TCI Chemical
Product number
H1713
Product name
8-Hydroxyquinoline-2-carbaldehyde
Packaging
1G
Price
$94
Updated
2025/07/31
TRC
Product number
H999865
Product name
8-Hydroxyquinoline-2-carbaldehyde
Packaging
500mg
Price
$110
Updated
2021/12/16
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8-Hydroxyquinoline-2-carboxaldehyde Chemical Properties,Usage,Production

Chemical Properties

yellow crystalline powder

Uses

8-Hydroxy-2-quinolinecarboxaldehyde (8-hydroxyquinoline-2-carbaldehyde) may be used in the preparation of:

  • 8-hydroxy-2-quinoline-1-aminopyrene by Schiff-base reaction with 1-aminopyrene
  • (E)-2-((2-(pyridin-2-yl)hydrazono)methyl)quinolin-8-ol by coupling with 2-hydrazinopyridine
  • 8-hydroxyquinoline-2-carbaldehyde oxime
  • 2-[(8-Hydroxyquinoline)-2-methylaminoethyl]-β-D-glucopyranoside

Definition

ChEBI: 8-hydroxyquinoline-2-carbaldehyde is a hydroxyquinoline.

General Description

8-Hydroxy-2-quinolinecarboxaldehyde can be prepared from 2-methylquinolin-8-ol via oxidation using selenium dioxide.

Synthesis

826-81-3

14510-06-6

General procedure for the synthesis of 8-hydroxyquinoline-2-carbaldehyde from 8-hydroxyquinaldine: Preparation of 3,3'-(1E,1'E)-(propane-1,3-diylbis(aza-1-yl-1-ylidene))bis(methyl-1-ylidene-1-ylidene)diquinolin-8-ol (H2PBIQ). A mixture of 8-hydroxy-2-methylquinoline (4 g, 25 mmol), selenium dioxide (3.5 g, 31 mmol), water (3 mL), and 1,4-diethylene glycol (300 mL) was stirred for 24 h at 80 °C under nitrogen protection. After completion of the reaction, the mixture was cooled, filtered and the filtrate evaporated. The resulting solid was purified by silica gel column chromatography (unfolding solvent was petroleum ether: ethyl acetate, 95:5, v/v) to afford pure yellow needle-like crystals of 8-hydroxyquinoline-2-carbaldehyde. The yield was 90%; 1H NMR (400 MHz, CDCl3): δ10.25 (s, 1H), 8.35 (d, J=8.5 Hz, 1H), 8.18 (s, 1H), 8.09 (d, J=8.5 Hz, 1H), 7.66 (t, J=8.0 Hz, 1H), 7.46 (d, J=8.2 Hz, 1H), and 7.31 (d, J=7.7Hz, 1H).

References

[1] RSC Advances, 2015, vol. 5, # 129, p. 107012 - 107019
[2] Inorganic Chemistry Communications, 2014, vol. 47, p. 13 - 16
[3] European Journal of Medicinal Chemistry, 2016, vol. 121, p. 864 - 879
[4] Inorganic Chemistry, 2013, vol. 52, # 11, p. 6346 - 6353
[5] Dalton Transactions, 2014, vol. 43, # 26, p. 10164 - 10174

8-Hydroxyquinoline-2-carboxaldehyde Preparation Products And Raw materials

Raw materials

1,4-Dioxane 8-Hydroxyquinaldine Selenium dioxide

Preparation Products

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8-Hydroxyquinoline-2-carboxaldehyde Suppliers

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14510-06-6, 8-Hydroxyquinoline-2-carboxaldehydeRelated Search:

8-Hydroxyquinoline CHLOROPHOSPHONAZO III Quinhydrone XANTHURENIC ACID 8-HYDROXYQUINOLINE-2-CARBOXYLIC ACID 4-HYDROXYQUINOLINE-3-CARBOXALDEHYDE 2-Quinolinecarboxaldehyde CHEMBRDG-BB 6613830 ETHYL 4-HYDROXY-8-METHOXYQUINALDATE 8-METHOXY-QUINOLINE-2-CARBALDEHYDE CHEMBRDG-BB 5175112 CHEMBRDG-BB 5175122 8-BENZYLOXY-QUINOLINE-2-CARBALDEHYDE xanthurenic acid 8-methyl ether CHEMBRDG-BB 5175110 8-Hydroxyquinoline-2-carboxaldehyde 8-METHOXYQUINOLINE-2-CARBOXAMIDE 8-ETHOXY-QUINOLINE-2-CARBALDEHYDE

  • 8-HYDROXYQUINOLINE-2-CARBOXALDEHYDE
  • 8-HYDROXY-QUINOLINE-2-CARBALDEHYDE
  • AKOS BBS-00000128
  • 8-Hydroxy-2-quinolinecarboxaldehyde
  • 8-HYDROXYQUINOLINE-2-CARBOXALDEHYDE 98%
  • 8-Hydroxy-2-quinolinecarbaldehyde
  • 8-Hydroxyquinoline-2-carboxaldehyde, 98% 1GR
  • 8-Hydroxyquinoline-2-carboxaldehyde, 98% 5GR
  • 8-Hydroxyquinoline-2-carboxaldehyde ,98%
  • 2-Quinolinecarboxaldehyde, 8-hydroxy-
  • 8-hydroxyquinaldaldehyde
  • Quinaldaldehyde, 8-hydroxy-
  • 8-<WBR>Hydroxy-<WBR>2-<WBR>quinolinecarboxaldehyde
  • 8-Hydroxy-2-quinolinecarboxaldehyde >=98.0% (GC)
  • 8-Hydroxyquinoline-2-carboxaldehyde ISO 9001：2015 REACH
  • 14510-06-6
  • 4510-06-6
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  • Quinolines
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  • Quinolines, Quinazolines and derivatives
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