4A3-SC8

Product Name: 4A3-SC8
CAS No.: 1857340-78-3
Chemical Name: 4A3-SC8
Synonyms: 4A3-SC8;4A3-SC8(P01)
CBNumber: CB113708673
Molecular Formula: C75H139N3O16S4
Formula Weight: 1467.18
MOL File: 1857340-78-3.mol

More

Less

4A3-SC8 Property

Boiling point:: 1127.383±65.00 °C(Press: 760.00 Torr)(predicted)
Density: 1.068±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
solubility: Chloroform: Soluble
Ethanol: Soluble
form: Liquid
pka: 9.329±0.50(predicted)
color: Colorless to light yellow
InChIKey: HMIDEMNFLBUNTB-UHFFFAOYSA-N
SMILES: N(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCCN(C)CCCN(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

4A3-SC8 Chemical Properties,Usage,Production

Uses

4A3-SC8 is a modular degradable dendrimer that enables small RNAs to extend survival in an aggressive liver cancer model[1].

in vivo

4A3-SC8 mediates siRNA accumulation mainly in liver and slightly in the spleen and kidneys 24 hours after intravenous injection at dosage of 1 mg siRNA/kg and enables >95% FVII knockdown in mice^[1].
After injection with 4A3-SC8 (100 mg/kg with 4 mg/kg control siRNA siCTR; i.v.; once), mice became sick and lost nearly 20% of their weight on the first day postinjection^[1].

References

[1] Zhou K, et al. Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):520-5. DOI:10.1073/pnas.1520756113
[2] ÁLVAREZ-BENEDICTO E, FARBIAK L, RAMÍREZ M M, et al. Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA)†[J]. Biomaterials Science, 2021, 2: 549-559. DOI: 10.1039/d1bm01454d
[3] LUKAS FARBIAK. All-In-One Dendrimer-Based Lipid Nanoparticles Enable Precise HDR-Mediated Gene Editing In Vivo[J]. Advanced Materials, 2021, 33 30. DOI: 10.1002/adma.202006619
[4] HU XIONG . Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo[J]. Journal of Controlled Release, 2020, 325: Pages 198-205. DOI: 10.1016/j.jconrel.2020.06.030

4A3-SC8 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4A3-SC8 Suppliers

China 22 Global 22

Shochem (Shanghai) Co.,Ltd

Tel: 13611745246 13816874662
Email: sales@shochem.com
Country: China
ProdList: 500
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 24972
Advantage: 58

Shanghai Changyu Medical Technology Co. Ltd.

Tel: +86-13301875428
Email: sales@changyuhe.com
Country: China
ProdList: 304
Advantage: 58

Shochem(Shanghai)Co.,Ltd

Tel: +86-021-51783479 +86-13816874662
Fax: 021-50800795
Email: info@shochem.com
Country: China
ProdList: 301
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: doncunbiosci@gmail.com
Country: China
ProdList: 544
Advantage: 58

Shanghai Keke Biotechnology Co., Ltd.

Tel: 021-34975789 18721102763
Email: click@click-biotech.com
Country: China
ProdList: 299
Advantage: 58

Wuxi Donghe Pharmaceutical Technology Co., Ltd.

Tel: 63313187 15358055255
Fax: QQ：63313187
Email: 63313187@qq.com
Country: China
ProdList: 1984
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 4920
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Guangzhou Weihua Biotechnology Co., Ltd

Tel: 02037239396 18922496242
Email: weihuasw@foxmail.com
Country: China
ProdList: 4738
Advantage: 58

1857340-78-3, 4A3-SC8Related Search:

4A3-SC8

4A3-SC8(P01)

1857340-78-3