gedunin
- Product Name
- gedunin
- CAS No.
- 2753-30-2
- Chemical Name
- gedunin
- Synonyms
- gedunin;Gedunine;Nsc113497;YJXDGWUNRYLINJ-BHAPSIHVSA-N;HSP90,Inhibitor,HSP,Heat shock proteins,inhibit,COVID-19,Gedunin,Alzheimer's disease,neurodegenerative disorder;(13α,17aα)-7α-Acetoxy-14β,15β:21,23-diepoxy-4,4,8-trimethyl-D-homo-24-nor-17-oxa-5α-chola-1,20,22-triene-3,16-dione;D-Homo-24-nor-17-oxachola-1,20,22-triene-3,16-dione, 7-(acetyloxy)-14,15:21,23-diepoxy-4,4,8-trimethyl-, (5.alpha.,7.alpha.,13.alpha.,14.beta.,15.beta.,17A.alpha.)-;16,17-Seco-24-nor-5.alpha.,13.alpha.,14.beta.,17.alpha.-chola-1,20,22-trien-16-oic acid, 14,15.beta.:21,23-diepoxy-7.alpha.,17-dihydroxy-4,4,8-trimethyl-3-oxo-, 16,17-lactone, acetate;(1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione;Oxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione, 5-(acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a-decahydro-4b,7,7,10a,12a-pentamethyl-, (1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-
- CBNumber
- CB11375904
- Molecular Formula
- C28H34O7
- Formula Weight
- 482.57
- MOL File
- 2753-30-2.mol
gedunin Property
- Melting point:
- 218 °C(Solv: methanol (67-56-1))
- Boiling point:
- 594.3±50.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- Chloroform (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
- LogP
- 3.201 (est)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 17328
- Product name
- Gedunin
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 3387
- Product name
- Gedunin
- Purity
- ≥98%(HPLC)
- Packaging
- 2
- Price
- $247
- Updated
- 2021/12/16
- Product number
- 255370
- Product name
- Gedunin
- Packaging
- 10mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- G303503
- Product name
- Gedunin
- Packaging
- 2.5mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- B7393
- Product name
- Gedunin
- Packaging
- 1mg
- Price
- $219
- Updated
- 2021/12/16
gedunin Chemical Properties,Usage,Production
Description
Gedunin is a natural inhibitor of the heat shock protein (Hsp90; Item Nos. 22734 | 22735) co-chaperone p23 that also inhibits Hsp90 expression in human teratocarcinomal NTERA-2 cells in vitro at 5 μg/ml. This tetranortriterpenoid, which is isolated from A. indica, binds to and blocks the chaperone activity of p23 to induce apoptosis in HeLa-PRB cells in vitro at a concentration of 20 μM. Gedunin inhibits breast cancer cell proliferation in vitro, with IC50 values of 8.84 and 3.22 μM in MCF-7 and SKBr-3 cells, respectively, and inhibits the growth of PANC-1 pancreatic cancer cells (IC50 = 25 μM) by targeting the sonic hedgehog pathway to induce apoptosis. It also exerts anti-inflammatory effects in vivo. In a mouse model of articular inflammation induced by zymosan , gedunin (0.05-0.5 mg/kg, i.p.) reduces edema formation and the production of inflammatory cytokines. Gedunin (0.5 mg/kg) also inhibits the pleural accumulation of eosinophils and activated T lymphocytes in an ovalbumin-sensitized mouse model of allergic inflammation when administered prior to ovalbumin rechallenge. It also targets the lipopolysaccharide binding site and thus blocks Toll-like receptor 4 (TLR4) signaling in macrophages in vitro at a concentration of 10 μM.
Uses
Gedunin is a naturally occurring Hsp90 inhibitor. In vitro, Gedunin induces Hsp90-dependent client protein degradation and displays antiproliferative activity (IC50 values are 3.22, 8.84 and 16.8 μM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Gedunin exhibits antimalarial activity against P. falciparum (IC50 values are 0.14 and 3.1 μM in parasite development and [3H]-hypoxanthine uptake assays respectively).
Definition
ChEBI: A pentacyclic triterpenoid natural product found particularly in Azadirachta indica and Cedrela odorata.
Biological Activity
Naturally occurring Hsp90 inhibitor. Induces Hsp90-dependent client protein degradation and displays antiproliferative activity in vitro (IC 50 values are 3.22, 8.84 and 16.8 μ M in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Also exhibits antimalarial activity against P. falciparum (IC 50 values are 0.14 and 3.1 μ M in parasite development and [ 3 H]-hypoxanthine uptake assays respectively).
in vitro
gedunin induces degradation of hsp90-dependent client protein and displays anti-proliferative activity in skbr3, caco-2 and mcf-7 cancer cell lines with ic50 of 3.22, 16.8 and 8.84 μm respectively1.
storage
Store at +4°C
References
1. uddin sj, nahar l, shilpi ja, et al. gedunin, a limonoid from xylocarpus granatum, inhibits the growth of caco-2 colon cancer cell line in vitro. phytotherapy research : ptr. 2007;21(8):757-761.2. lee se, kim mr, kim jh, et al. antimalarial activity of anthothecol derived from khaya anthotheca (meliaceae). phytomedicine : international journal of phytotherapy and phytopharmacology. 2008;15(6-7):533-535.3. conte fp, ferraris fk, costa te, et al. effect of gedunin on acute articular inflammation and hypernociception in mice. molecules. 2015;20(2):2636-2657.
gedunin Preparation Products And Raw materials
Raw materials
Preparation Products
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