N,N'-bis(salicylideneamino)ethane-manganese(II)

Product Name: N,N'-bis(salicylideneamino)ethane-manganese(II)
CAS No.: 53177-12-1
Chemical Name: N,N'-bis(salicylideneamino)ethane-manganese(II)
Synonyms: EUK-8;EUK-8 >=95% (HPLC);Manganese(salen) chloride;(Salen)manganese(III) chloride;(Salen)manganese(III) chloride (EUK-8);Manganese(salen) chloride, 10 mM in DMSO;N,N'-bis(salicylideneamino)ethane-manganese(II);Chloro(bis(salicylidene)ethylenediamine)manganese;Chloro[N,N′-ethylenebis(salicylideneaminato)]manganese;N,N'-Bis(salicylidene)-1,2-ethylenediamine-manganese(II)
CBNumber: CB11380553
Molecular Formula: C16H14ClMnN2O2
Formula Weight: 356.685609
MOL File: 53177-12-1.mol

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N,N'-bis(salicylideneamino)ethane-manganese(II) Property

storage temp.: -20°C
solubility: H2O: soluble1mg/mL, clear
form: powder
color: faint to very dark brown
Water Solubility: H2O: 1mg/mL, clear

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0742
Product name: EUK-8
Purity: ≥95% (HPLC)
Packaging: 10mg
Price: $91.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0742
Product name: EUK-8
Purity: ≥95% (HPLC)
Packaging: 50mg
Price: $471.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: 341209
Product name: EUK-8
Purity: A synthetic salen-manganese complex with high superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities.
Packaging: 10MG
Price: $110
Updated: 2025/07/31

TRC

Product number: D493573
Product name: [N,N0-Disalicylidene-1,2-ethanediaminato-(2-)]manganese(III)Chloride
Packaging: 500mg
Price: $695
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0136655
Product name: CHLORO(BIS(SALICYLIDENE)ETHYLENEDIAMINE)MANGANESE
Purity: 95.00%
Packaging: 5MG
Price: $502.72
Updated: 2021/12/16

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N,N'-bis(salicylideneamino)ethane-manganese(II) Chemical Properties,Usage,Production

Uses

[N,N 0-Disalicylidene-1,2-ethanediaminato-(2-)]manganese(III) Chloride is an oxidation catalysts and an enzyme mimetic. It also functions as an intermediate in the synthesis of manganese(III) complexes with fluorinated salen derivatives that exhibits antioxidant properties.

Biochem/physiol Actions

EUK-8 is a salen manganese complex that exhibit potent antioxidant activities. EUK-8 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-8 disrupts the pre-formed amyloid fibrils. EUK-8 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils.

in vivo

Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant^[3].

Animal Model:	Wild-type (WT) and harlequin (Hq) B6CBA male and female mice^[3]
Dosage:	25 mg/kg/day
Administration:	I.p. 3 times a week for 4 weeks
Result:	Prevented myocardial oxidant damage provoked by biomechanical stress. Improved survival following biomechanical stress. Prevented functional and geometrical deterioration in response to pressure overload. Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis.

N,N'-bis(salicylideneamino)ethane-manganese(II) Preparation Products And Raw materials

Raw materials

Preparation Products

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N,N'-bis(salicylideneamino)ethane-manganese(II) Suppliers

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53177-12-1, N,N'-bis(salicylideneamino)ethane-manganese(II)Related Search:

N,N'-Bis(salicylidene)-1,2-ethylenediamine-manganese(II) (SP-5-13)-Chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-alphaN)methylidyne]]bis[phenolato-alphaO]](2-)]manganese

(Salen)manganese(III) chloride

(SP-5-13)-Chloro[[2,2′-[1,2-ethanediylbis(nitrilomethylidyne)]bis[phenolato]](2-)-N,N′,O,O′]-manganese

Chloro(bis(salicylidene)ethylenediamine)manganese

Chloro[N,N′-ethylenebis(salicylideneaminato)]manganese

Manganese(salen) chloride

N,N'-bis(salicylideneamino)ethane-manganese(II)

EUK-8

(SP-5-13)-Chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-alphaN)methylidyne]]bis[phenolato-alphaO]](2-)]manganese

N,N'-Bis(salicylidene)-1,2-ethylenediamine-manganese(II)

EUK-8 >=95% (HPLC)

(Salen)manganese(III) chloride (EUK-8)

Manganese(salen),inhibit,dismutase,EUK8,catalase,oxyradical,mimetic,Inhibitor,antioxidant,EUK 8,superoxide,Reactive Oxygen Species,Manganese(salen) chloride,scavenging

Manganese(salen) chloride, 10 mM in DMSO

53177-12-1

C16H14ClMnN2O2