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N,N'-bis(salicylideneamino)ethane-manganese(II)

Product Name
N,N'-bis(salicylideneamino)ethane-manganese(II)
CAS No.
53177-12-1
Chemical Name
N,N'-bis(salicylideneamino)ethane-manganese(II)
Synonyms
EUK-8;EUK-8 >=95% (HPLC);Manganese(salen) chloride;(Salen)manganese(III) chloride;(Salen)manganese(III) chloride (EUK-8);Manganese(salen) chloride, 10 mM in DMSO;N,N'-bis(salicylideneamino)ethane-manganese(II);Chloro(bis(salicylidene)ethylenediamine)manganese;Chloro[N,N′-ethylenebis(salicylideneaminato)]manganese;N,N'-Bis(salicylidene)-1,2-ethylenediamine-manganese(II)
CBNumber
CB11380553
Molecular Formula
C16H14ClMnN2O2
Formula Weight
356.685609
MOL File
53177-12-1.mol
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N,N'-bis(salicylideneamino)ethane-manganese(II) Property

storage temp. 
-20°C
solubility 
H2O: soluble1mg/mL, clear
form 
powder
color 
faint to very dark brown
Water Solubility 
H2O: 1mg/mL, clear
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0742
Product name
EUK-8
Purity
≥95% (HPLC)
Packaging
10mg
Price
$91.7
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0742
Product name
EUK-8
Purity
≥95% (HPLC)
Packaging
50mg
Price
$471.2
Updated
2025/07/31
Sigma-Aldrich
Product number
341209
Product name
EUK-8
Purity
A synthetic salen-manganese complex with high superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities.
Packaging
10MG
Price
$110
Updated
2025/07/31
TRC
Product number
D493573
Product name
[N,N0-Disalicylidene-1,2-ethanediaminato-(2-)]manganese(III)Chloride
Packaging
500mg
Price
$695
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0136655
Product name
CHLORO(BIS(SALICYLIDENE)ETHYLENEDIAMINE)MANGANESE
Purity
95.00%
Packaging
5MG
Price
$502.72
Updated
2021/12/16
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N,N'-bis(salicylideneamino)ethane-manganese(II) Chemical Properties,Usage,Production

Uses

[N,N 0-Disalicylidene-1,2-ethanediaminato-(2-)]manganese(III) Chloride is an oxidation catalysts and an enzyme mimetic. It also functions as an intermediate in the synthesis of manganese(III) complexes with fluorinated salen derivatives that exhibits antioxidant properties.

Biochem/physiol Actions

EUK-8 is a salen manganese complex that exhibit potent antioxidant activities. EUK-8 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-8 disrupts the pre-formed amyloid fibrils. EUK-8 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils.

in vivo

Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant[3].

Animal Model:Wild-type (WT) and harlequin (Hq) B6CBA male and female mice[3]
Dosage:25 mg/kg/day
Administration:I.p. 3 times a week for 4 weeks
Result:Prevented myocardial oxidant damage provoked by biomechanical stress.
Improved survival following biomechanical stress.
Prevented functional and geometrical deterioration in response to pressure overload.
Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis.

N,N'-bis(salicylideneamino)ethane-manganese(II) Preparation Products And Raw materials

Raw materials

Preparation Products

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N,N'-bis(salicylideneamino)ethane-manganese(II) Suppliers

Canada 1 China 43 United States 5 Global 49
TargetMol Chemicals Inc.
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United States
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TargetMol Chemicals Inc.
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support@targetmol.com
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United States
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53177-12-1, N,N'-bis(salicylideneamino)ethane-manganese(II)Related Search:


  • N,N'-Bis(salicylidene)-1,2-ethylenediamine-manganese(II) (SP-5-13)-Chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-alphaN)methylidyne]]bis[phenolato-alphaO]](2-)]manganese
  • (Salen)manganese(III) chloride
  • (SP-5-13)-Chloro[[2,2′-[1,2-ethanediylbis(nitrilomethylidyne)]bis[phenolato]](2-)-N,N′,O,O′]-manganese
  • Chloro(bis(salicylidene)ethylenediamine)manganese
  • Chloro[N,N′-ethylenebis(salicylideneaminato)]manganese
  • Manganese(salen) chloride
  • N,N'-bis(salicylideneamino)ethane-manganese(II)
  • EUK-8
  • (SP-5-13)-Chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-alphaN)methylidyne]]bis[phenolato-alphaO]](2-)]manganese
  • N,N'-Bis(salicylidene)-1,2-ethylenediamine-manganese(II)
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  • Manganese(salen) chloride, 10 mM in DMSO
  • 53177-12-1
  • C16H14ClMnN2O2