ChemicalBook > CAS DataBase List > 2-AMINO-BENZOTHIAZOL-6-OL

2-AMINO-BENZOTHIAZOL-6-OL

Product Name
2-AMINO-BENZOTHIAZOL-6-OL
CAS No.
26278-79-5
Chemical Name
2-AMINO-BENZOTHIAZOL-6-OL
Synonyms
ASISCHEM X25426;VITAS-BB TBB000062;TIMTEC-BB SBB010476;2-Amino-6-benzothiazolol;2-AMINO-BENZOTHIAZOL-6-OL;2-AMINO-BENZOTHIAZOLE-6-OL;6-Benzothiazolol, 2-amino-;2-AMINOBENZO[D]THIAZOL-6-OL;6-Hydroxybenzothiazol-2-amine;2-AMINO-1,3-BENZOTHIAZOL-6-OL
CBNumber
CB1139543
Molecular Formula
C7H6N2OS
Formula Weight
166.2
MOL File
26278-79-5.mol
More
Less

2-AMINO-BENZOTHIAZOL-6-OL Property

Melting point:
243-250℃
Boiling point:
394.6±34.0 °C(Predicted)
Density 
1.553±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
8.69±0.40(Predicted)
form 
solid
Appearance
Off-white to gray Solid
InChI
InChI=1S/C7H6N2OS/c8-7-9-5-2-1-4(10)3-6(5)11-7/h1-3,10H,(H2,8,9)
InChIKey
VLNVTNUTGNBNBY-UHFFFAOYSA-N
SMILES
S1C2=CC(O)=CC=C2N=C1N
CAS DataBase Reference
26278-79-5(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-36-20/21/22-22
Safety Statements 
26-36/37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2934208090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
750786
Product name
2-Amino-6-hydroxybenzothiazole
Purity
95%
Packaging
1g
Price
$29
Updated
2025/07/31
Sigma-Aldrich
Product number
CDS007524
Product name
2-amino-benzothiazol-6-ol
Purity
AldrichCPR
Packaging
1g
Price
$104
Updated
2024/03/01
TRC
Product number
A634688
Product name
2-Amino-6-hydroxybenzothiazole
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
A634688
Product name
2-Amino-6-hydroxybenzothiazole
Packaging
100mg
Price
$60
Updated
2021/12/16
Oakwood
Product number
015339
Product name
2-Amino-benzothiazol-6-ol
Packaging
250mg
Price
$12
Updated
2021/12/16
More
Less

2-AMINO-BENZOTHIAZOL-6-OL Chemical Properties,Usage,Production

Uses

2-Amino-6-hydroxybenzothiazole is a reagent used in the chemical synthesis of new benzothiazole derivatives with anti proliferative and antiiconvulsant activity.

Synthesis Reference(s)

The Journal of Organic Chemistry, 35, p. 4103, 1970 DOI: 10.1021/jo00837a003

Synthesis

1520-27-0

26278-79-5

General procedure for the synthesis of 2-amino-6-hydroxybenzothiazole from 1-(4-hydroxyphenyl)thiourea: 1-(4-hydroxyphenyl)thiourea (5 g, 29.7 mmol) was dissolved in chloroform (30 mL) in a 100 mL two-necked round-bottomed flask fitted with a stirrer. The chloroform (15 mL) solution of bromine (5 g, 29.7 mmol) was transferred to a dropping funnel and slowly added dropwise to the reaction mixture under stirring while controlling the reaction temperature to be lower than 5 °C. After the dropwise addition, the reaction was continued with stirring for 4-6 hours. Subsequently, the reaction mixture was refluxed on a water bath until no more hydrogen bromide gas escaped. After completion of the reaction, the resulting solid was treated with ice water and filtered. The filtrate was neutralized with ammonia solution and the precipitated white precipitate was filtered and washed with water. Finally, the product 2-amino-6-hydroxybenzothiazole was recrystallized from ethanol to give a white solid powder (4 g, 80% yield). The structure of the product was confirmed by 1H NMR (DMSO-d6, 400 MHz): δ 9.10 (s, 1H, -OH), 7.13 (d, J = 8.4 Hz, 1H, ArH, C5-H), 7.06 (s, 2H, -NH2), 7.01 (d, J = 2.4 Hz, 1H, ArH, C4-H), 6.65 (dd, J = 2.6 , 8.6 Hz, 1H, ArH, C7-H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 15, p. 3460 - 3463
[2] Medicinal Chemistry Research, 2012, vol. 21, # 7, p. 1136 - 1148
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 21, p. 9814 - 9824

2-AMINO-BENZOTHIAZOL-6-OL Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-AMINO-BENZOTHIAZOL-6-OL Suppliers

Canada 1 China 122 Europe 1 France 1 Germany 4 India 3 Russia 3 Ukraine 1 United Kingdom 7 United States 20 Global 163
Hangzhou Fuze Pharmaceutical Technology Co., Ltd.
Tel
0572-0571-82870240 13586109179
Email
47302108@qq.com
Country
China
ProdList
221
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
ZEROSCHEM.CO.,LTD.
Tel
10-61256048 13810278579
Fax
+86 10 61256049
Email
sales@zeroschem.com
Country
China
ProdList
1371
Advantage
59
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Chiba Pharmaceutical Science and technology Co, Ltd.
Tel
0531-81313138 13066006660
Fax
QQ: 3366077777
Email
chibapharm@foxmail.com
Country
China
ProdList
3991
Advantage
55
Tianjin YongSheng Biotechnology Co., Ltd.
Tel
022-60987737 13512258274
Fax
86-022-23500597
Email
sales@immortalbio.com
Country
China
ProdList
154
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Nanjing Norris-Pharm Technology Co., Ltd
Tel
18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
8878
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Taizhou Yikang Chemical Co., Ltd.
Tel
0576-88501337 18906763631
Fax
+86-576-88501337
Email
sales@yikangchemicals.com
Country
China
ProdList
270
Advantage
58
Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5674
Advantage
50
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Bellen Chemistry Co., Ltd.
Tel
010-60400365-8001 15910885229
Fax
010-60400361
Email
service@bellenchem.com
Country
China
ProdList
4514
Advantage
60
Shanghai Boyners Pharm-Tech Co., Ltd.
Tel
13817873692
Fax
021-31329586
Email
mkt@boynerspharm.com
Country
China
ProdList
1707
Advantage
55
SanoChem (Chengdu) Tech. Co., Ltd.
Tel
28-87999436 02887999436
Fax
QQ:2746983436
Email
sales@sano-chem.com
Country
China
ProdList
3795
Advantage
55
Yancheng Schiemann Biological Technology Co.,Ltd
Tel
515-88280676 18921872653
Email
sales@ximanbio.com
Country
China
ProdList
1524
Advantage
56
Wuhan Chemwish Technology Co.， Ltd
Tel
027-67849912
Fax
027-87531808
Email
sales@chemwish.com
Country
China
ProdList
9148
Advantage
60
Nanjing Vital Chemical Co., Ltd.
Tel
025-87193546 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
9021
Advantage
60
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10453
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Radiant Pharma & Tech. Co., Ltd
Tel
T:15050866711
Fax
QQ:2677337387
Email
wanglin.chen@radiant-pharma.com
Country
China
ProdList
466
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9125
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Guangdong wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2886750 13927877953
Fax
0751-2886750
Email
3005811397@qq.com
Country
China
ProdList
13305
Advantage
58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-50664929, 13971561712
Fax
027-50664927 / QQ: 3452835437
Email
hubxys2001@163.com
Country
China
ProdList
1437
Advantage
55
Guangzhou Jhd Chemical Reagent Co., Ltd.
Tel
020-84383047
Fax
020-84380294
Email
sales@jhd.com.cn
Country
China
ProdList
9186
Advantage
65
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
021-021-52271985 17721149837
Fax
+86 (21) 52271987
Email
sales@9dingchem.com
Country
China
ProdList
19800
Advantage
60
Biokitchen
Tel
021-021-021-31663258 13795219287
Fax
021-31663258
Email
donghuanwen@126.com
Country
China
ProdList
8816
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29735
Advantage
60
Aikon International Limited
Tel
025-58859352 18068836627
Fax
(5)02557626880
Email
dt3@aikonchem.com
Country
China
ProdList
15493
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Nanjing crow LuNing pharmaceutical technology co., LTD
Tel
13382066392
Country
CHINA
ProdList
4877
Advantage
58
Shanghai Maruhua Science and Technology Co. Ltd.
Tel
021-57171708 18721745940
Fax
QQ1139783351
Email
sales@api-chem.com
Country
China
ProdList
1968
Advantage
58
Cool Pharm, Ltd
Tel
021-58581007 18019463053
Fax
021-50966098
Email
sales@coolpharm.com
Country
China
ProdList
12878
Advantage
58
Jinan Carbotang Biotech Co.,Ltd.
Tel
+8615866703830
Email
figo.gao@foxmail.com
Country
China
ProdList
8497
Advantage
58
CR Corporation Limited
Tel
+8613062833949
Email
fred.wen@crcorporation.cn
Country
China
ProdList
8645
Advantage
58
Unipharm pharmaceutical industry Co., Ltd
Tel
536-8266195 +8613953676784
Email
lee@unipharm-sd.com
Country
China
ProdList
1202
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34563
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-0571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52846
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30229
Advantage
58
Henan Weituxi Chemical Technology Co., Ltd.
Tel
0371-63284658 18135795563
Fax
QQ:2885349392
Email
2885349392@qq.com
Country
China
ProdList
9992
Advantage
58
Wuhan Ruilida Biomedical Technology Co., Ltd.
Tel
18201884268
Email
magean83@163.com
Country
China
ProdList
1960
Advantage
58
Ningbo Haorui Biological Technology Co., Ltd.
Tel
15221000252
Email
278450236@qq.com
Country
China
ProdList
203
Advantage
58
Zhejiang Lianshuo Biotechnology Co., Ltd.
Tel
18616526224
Email
lianshuo@vip.126.com
Country
China
ProdList
9607
Advantage
58
More
Less

View Lastest Price from 2-AMINO-BENZOTHIAZOL-6-OL manufacturers

Career Henan Chemica Co
Product
2-AMINO-BENZOTHIAZOL-6-OL 26278-79-5
Price
US $0.37/KG
Min. Order
1KG
Purity
99%
Supply Ability
10kg/100kg
Release date
2020-11-09
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-AMINO-BENZOTHIAZOL-6-OL 26278-79-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

26278-79-5, 2-AMINO-BENZOTHIAZOL-6-OLRelated Search:

2-Amino-6-ethoxybenzothiazole 2-AMINO-BENZOTHIAZOL-6-OL 2-AMINO-BENZOTHIAZOL-4-OL 2-ACETOACETAMIDO-6-ETHOXYBENZOTHIAZOLE Basic Blue 54 2-Amino-6-methoxybenzothiazole Frentizole Riluzole BASIC BLUE 41 (C.I. 11105) 6-Benzothiazolol(7CI,8CI,9CI) 2-DIMETHYLAMINO-6-BENZOTHIAZOLOL 2-CHLORO-N-(6-ETHOXY-BENZOTHIAZOL-2-YL)-ACETAMIDE 2-CHLORO-N-(6-METHOXY-BENZOTHIAZOL-2-YL)-ACETAMIDE SUPRACET BRILLIANT RED BD 2-AMINO-6-ETHOXYBENZOTHIAZOLE HCL N-(4-(((6-ETHOXYBENZOTHIAZOL-2-YL)AMINO)SULFONYL)PHENYL)ETHANAMIDE BASIC BLUE 66 5-(((6-ETHOXYBENZOTHIAZOL-2-YL)AMINO)METHYLENE)-2,2-DIMETHYL-1,3-DIOXANE-4,6-DIONE

  • 2-AMINO-1,3-BENZOTHIAZOL-6-OL
  • 2-AMINO-BENZOTHIAZOL-6-OL
  • 2-AMINO-BENZOTHIAZOLE-6-OL
  • 2-AMINOBENZO[D]THIAZOL-6-OL
  • 2-AMINO-6-HYDROXYBENZOTHIAZOLE
  • 2-Amino-6-hydroxy-1,3-benzothiazole
  • 2-aMino-6-hydroxybenzothiazole, 2-aMino-6-hydroxybenzothiazol
  • 2-Amino-6-benzothiazolol
  • 6-Hydroxybenzothiazol-2-amine
  • ASISCHEM X25426
  • VITAS-BB TBB000062
  • 2-amino-6-hydroxy-benzothiazol
  • TIMTEC-BB SBB010476
  • 6-Benzothiazolol,2-amino-(8CI,9CI)
  • 6-HYDROXY-2-AMINOBENZOTHIAZOLE
  • 6-HYDROXY-2-AMINOBENZTHIAZOLE
  • 6-Benzothiazolol, 2-amino-
  • 2-Thiazolamine,4-(4-methoxyphenyl)-10-methyl-
  • 26278-79-5
  • BENZOTHIAZOLE
  • Building Blocks
  • C3 to C7
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • New Products for Chemical Synthesis
  • Thiazoles