Actisomide

Actisomide Property

Melting point:

201-202 °C(Solv: ethyl ether (60-29-7))

Boiling point:

473.9±55.0 °C(Predicted)

Density 

1.08±0.1 g/cm3(Predicted)

pka

10.51±0.28(Predicted)

Hazard and Precautionary Statements (GHS)

Actisomide Chemical Properties,Usage,Production

Originator

Dizactamide ,ZYF Pharm Chemical

Manufacturing Process

Hydrogenation of 4-diisopropylamino-2-phenyl-2-pyridin-2-yl-butyramide over platinum oxide catalyst reduced the pyridine ring to a piperidine to give 4- diisopropylamino-2-phenyl-2-piperidin-2-yl-butyramide as a white solid, MP: 107°-108°C. Structure was confirmed by proton, carbon-13-NMR spectra and by elemental analysis.
2-(1-Acetylpiperidin-2-yl)-4-diisopropylamino-2-phenylbutyramide was prepared by acetylation of above product with N,N-dimethylacetamide dimethylacetal by heating at 80°C for about 14 hours. The acetamide melted at 191°-192°C. The treatment of that intermediate with lithium aluminum hydride led the newly introduced acetyl group to condense with the adjacent amide nitrogen. There was thus obtained 4-(2-diisopropylaminoethyl)-1- methyl-4-phenyl-4,4a,5,6,7,8-hexahydropyrido[1,2-c]pyrimidin-3-one, the new anti-arrhythmic agent actisomide, MP: 70°-75°C. Its structure was confirmed by proton NMR and infrared spectra and by elemental analysis.

brand name

Cardiac depressant (anti-arrhythmic).

Therapeutic Function

Cardiac depressant