Actisomide
- Product Name
- Actisomide
- CAS No.
- 96914-39-5
- Chemical Name
- Actisomide
- Synonyms
- Actisomide;(4R,4aR)-4-[2-(Diisopropylamino)ethyl]-1-methyl-4-phenyl-4,4a,5,6 ,7,8-hexahydro-3H-pyrido[1,2-c]pyrimidin-3-one;(+/-)-trans-4-ethyl>-4,4a,5,6,7,8-hexahydro-1-methyl-4-phenyl-3H-pyrido-pyrimidin-3-one;3H-Pyrido[1,2-c]pyrimidin-3-one, 4-[2-[bis(1-methylethyl)amino]ethyl]-4,4a,5,6,7,8-hexahydro-1-methyl-4-phenyl-, (4R,4aR)-rel-
- CBNumber
- CB11401924
- Molecular Formula
- C23H35N3O
- Formula Weight
- 369.54
- MOL File
- 96914-39-5.mol
Actisomide Property
- Melting point:
- 201-202 °C(Solv: ethyl ether (60-29-7))
- Boiling point:
- 473.9±55.0 °C(Predicted)
- Density
- 1.08±0.1 g/cm3(Predicted)
- pka
- 10.51±0.28(Predicted)
N-Bromosuccinimide Price
- Product number
- API0010616
- Product name
- ACTISOMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.35
- Updated
- 2021/12/16
Actisomide Chemical Properties,Usage,Production
Originator
Dizactamide ,ZYF Pharm Chemical
Manufacturing Process
Hydrogenation of 4-diisopropylamino-2-phenyl-2-pyridin-2-yl-butyramide over
platinum oxide catalyst reduced the pyridine ring to a piperidine to give 4-
diisopropylamino-2-phenyl-2-piperidin-2-yl-butyramide as a white solid, MP:
107°-108°C. Structure was confirmed by proton, carbon-13-NMR spectra and
by elemental analysis.
2-(1-Acetylpiperidin-2-yl)-4-diisopropylamino-2-phenylbutyramide was
prepared by acetylation of above product with N,N-dimethylacetamide
dimethylacetal by heating at 80°C for about 14 hours. The acetamide melted
at 191°-192°C. The treatment of that intermediate with lithium aluminum
hydride led the newly introduced acetyl group to condense with the adjacent
amide nitrogen. There was thus obtained 4-(2-diisopropylaminoethyl)-1-
methyl-4-phenyl-4,4a,5,6,7,8-hexahydropyrido[1,2-c]pyrimidin-3-one, the
new anti-arrhythmic agent actisomide, MP: 70°-75°C. Its structure was
confirmed by proton NMR and infrared spectra and by elemental analysis.
brand name
Cardiac depressant (anti-arrhythmic).
Therapeutic Function
Cardiac depressant
Actisomide Preparation Products And Raw materials
Raw materials
Preparation Products
Actisomide Suppliers
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