PHOSPHORAMIDEMUSTARD
- Product Name
- PHOSPHORAMIDEMUSTARD
- CAS No.
- 1566-15-0
- Chemical Name
- PHOSPHORAMIDEMUSTARD
- Synonyms
- Ai3-51834;Phosphamide Mustard;Phosphoramide mustard cyclohexylamine;Phosphamide Mustard Cyclohexamine Salt;Phosphoramide mustard (cyclohexanamine);Phosphamide mustard cyclohexylamine salt;Phosphoramide mustard cyclohexylammonium salt;amino-[bis(2-chloroethyl)amino]phosphinic acid,cyclohexanamine;N,N-Bis(2-chloroethyl)phosphorodiaMidic Acid CyclohexylaMine Salt;Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-, compound with cyclohexanamine (1:1)
- CBNumber
- CB11447771
- Molecular Formula
- C10H24Cl2N3O2P
- Formula Weight
- 320.196221
- MOL File
- 1566-15-0.mol
PHOSPHORAMIDEMUSTARD Property
- Melting point:
- 100-103°C
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Moisture Sensitive
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SMB01361
- Product name
- Phosphoramide mustard cyclohexylamine
- Purity
- ≥95% (HPLC)
- Packaging
- 1MG
- Price
- $72.2
- Updated
- 2025/07/31
- Product number
- SMB01361
- Product name
- Phosphoramide mustard cyclohexylamine
- Purity
- ≥95% (HPLC)
- Packaging
- 5MG
- Price
- $289
- Updated
- 2025/07/31
- Product number
- B418995
- Product name
- N,N-Bis(2-chloroethyl)phosphorodiamidicAcidCyclohexylamineSalt
- Packaging
- 5mg
- Price
- $215
- Updated
- 2021/12/16
- Product number
- CS-0137705
- Product name
- Phosphoramidemustard(cyclohexanamine)
- Packaging
- 5mg
- Price
- $680
- Updated
- 2021/12/16
- Product number
- CS-0137705
- Product name
- Phosphoramidemustard(cyclohexanamine)
- Packaging
- 10mg
- Price
- $1250
- Updated
- 2021/12/16
PHOSPHORAMIDEMUSTARD Chemical Properties,Usage,Production
Uses
N,N-Bis(2-chloroethyl)phosphorodiamidic Acid Cyclohexylamine Salt is a cytotoxic metabolite of Cyclophosphamide (C988580).
Biological Activity
Phosphoramide mustard cyclohexanamine induces cytotoxicity by forming cross-linked DNA adducts th at hinder DNA strand separation during replication. This compound destroys rapidly dividing cells and leads to DNA damage. In a study with r at ovarian granulosa cells (SIGCs), it reduced cell viability and increased DNA damage response (DDR) gene expression and protein levels. In animal models, it exhibited significant anticancer activity by inhibiting tumor growth. These findings highlight the potential of Phosphoramide mustard cyclohexanamine in cancer research
in vivo
Phosphoramide mustard cyclohexanamine (2.1-20.7 mg/kg; i.p.; daily; for 5 days) inhibits subcutaneous tumor growth in rats[2].
?
Phosphoramide mustard cyclohexanamine exhibits terminal elimination half-lives (rat 15.1 min) following intravenous administration (rat 59.4 mg/kg)[2].
| Animal Model: | Rat, subcutaneously implanted Walker 256 carcinosarcoma tumor[2] |
| Dosage: | 2.1 mg/kg, 4.8 mg/kg, 10.4 mg/kg, 20.7 mg/kg |
| Administration: | Intraperitoneal injection, once daily, for 5 consecutive days |
| Result: | Required to produce 50% inhibition of subcutaneous tumor growth with dose of 12 mg/kg. |
| Animal Model: | Rats[2] |
| Dosage: | 86.0 mg/kg (Pharmacokinetic Analysis) |
| Administration: | Intravenous injection |
| Result: | T1/2 (15.1 min). |
PHOSPHORAMIDEMUSTARD Preparation Products And Raw materials
Raw materials
Preparation Products
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