2,3-Diamino-5-trifluoromethylpyridine
- Product Name
- 2,3-Diamino-5-trifluoromethylpyridine
- CAS No.
- 107867-51-6
- Chemical Name
- 2,3-Diamino-5-trifluoromethylpyridine
- Synonyms
- 109527;2,3-Diamino-5-trifluoromethylpyridin;2,3-Diamino-5-trifluoromethylpyridine;5-(trifluoromethyl)-2,3-pyridinediamine;5-(TrifluoroMethyl)pyridine-2,3-diaMine;2,3-PyridinediaMine,5-(trifluoroMethyl)-;5-(Trifluoromethyl)pyridine-2,3-diamine 98%
- CBNumber
- CB11471051
- Molecular Formula
- C6H6F3N3
- Formula Weight
- 177.13
- MOL File
- 107867-51-6.mol
2,3-Diamino-5-trifluoromethylpyridine Property
- Boiling point:
- 296.7±40.0 °C(Predicted)
- Density
- 1.467±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 4.43±0.49(Predicted)
- Appearance
- Light brown to yellow Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PC51080
- Product name
- 5-(Trifluoromethyl)pyridine-2,3-diamine
- Purity
- 98%
- Packaging
- 100mg
- Price
- $99
- Updated
- 2021/12/16
- Product number
- PC51080
- Product name
- 5-(Trifluoromethyl)pyridine-2,3-diamine
- Purity
- 98%
- Packaging
- 250mg
- Price
- $159
- Updated
- 2021/12/16
- Product number
- 3H30-3-U0
- Product name
- 5-(Trifluoromethyl)pyridine-2,3-diamine
- Packaging
- 100mg
- Price
- $159
- Updated
- 2021/12/16
- Product number
- 3H30-3-U0
- Product name
- 5-(Trifluoromethyl)pyridine-2,3-diamine
- Packaging
- 250mg
- Price
- $255
- Updated
- 2021/12/16
- Product number
- PC51080
- Product name
- 5-(Trifluoromethyl)pyridine-2,3-diamine
- Purity
- 98%
- Packaging
- 1g
- Price
- $396
- Updated
- 2021/12/16
2,3-Diamino-5-trifluoromethylpyridine Chemical Properties,Usage,Production
Synthesis
79456-30-7
107867-51-6
General procedure for the synthesis of 2,3-diamino-5-trifluoromethylpyridine from 2-amino-3-bromo-5-trifluoromethylpyridine: In an autoclave reactor, 40 g of 2-amino-3-bromo-5-trifluoromethylpyridine, 2.2 g of copper(II) acetylacetonate, 6.6 g of acetylacetonate, 59 g of cesium carbonate, and 105 mL of N-methyl pyrrolidinone (NMP) were added in sequence. Under cooling in an ice bath, 25 mL of 28% ammonia solution was slowly added. After sealing the reactor, the reaction system was warmed to 110 °C and the reaction was stirred at this temperature for 12 hours. Upon completion of the reaction, the mixture was cooled to room temperature in an ice bath, diluted with water and extracted with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give 15 g of 2,3-diamino-5-trifluoromethylpyridine.1H-NMR (CDCl3) δ of 2,3-diamino-5-trifluoromethylpyridine: 7.93 (1H, d), 7.04 (1H, d), 4.71 (2H, brs), 3.46 (2H, brs).
References
[1] Patent: EP2865266, 2015, A1. Location in patent: Paragraph 0677
2,3-Diamino-5-trifluoromethylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2,3-Diamino-5-trifluoromethylpyridine Suppliers
- Tel
- +49 5662 408730
- Fax
- +49 5662 4087320
- info@synchem.de
- Country
- Germany
- ProdList
- 4705
- Advantage
- 70