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2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE

Product Name
2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE
CAS No.
194085-75-1
Chemical Name
2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE
Synonyms
YKP 509;RWJ 333369;Carisbamate;JNJ 10234094;(S)-Carisbamate;CarisbaMate (RWJ-333369);2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE;[(2S)-2-(2-chlorophenyl)-2-hydroxyethyl] carbamate;1,2-ETHANEDIOL,1-(2-CHLOROPHENYL)-, 2-CARBAMATE, (S)-;1,2-Ethanediol,1-(2-chlorophenyl)-, 2-carbaMate, (1S)-
CBNumber
CB11474577
Molecular Formula
C813CH8D2Cl15NO3
Formula Weight
215.63
MOL File
194085-75-1.mol
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2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE Property

Melting point:
131-132°C
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23514
Product name
Carisbamate
Purity
≥98%
Packaging
500μg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
23514
Product name
Carisbamate
Purity
≥98%
Packaging
1mg
Price
$218
Updated
2024/03/01
TRC
Product number
C183510
Product name
(S)-Carisbamate
Packaging
5mg
Price
$215
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009416
Product name
CARISBAMATE
Purity
95.00%
Packaging
1MG
Price
$315
Updated
2021/12/16
AK Scientific
Product number
X3698
Product name
(S)-Carisbamate
Packaging
1mg
Price
$340
Updated
2021/12/16
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2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE Chemical Properties,Usage,Production

Description

Carisbamate is an antiepileptic agent., In vivo, administration of carisbamate (10-60 mg/kg) dose-dependently reduces spike and wave discharges in the frontoparietal cortex in a rat model of absence seizures. Carisbamate (10 mg/kg) increases latency to the first running episode in the Wistar audiogenic sensitive rat model of convulsive seizures. It also reduces motor seizure frequency in a rat model of spontaneous seizures in a dose-dependent manner. Carisbamate blocks Nav1.2 channels (IC50 = 68 μM for rat channels) and inhibits repetitive firing of action potentials in rat hippocampal neurons in a dose-dependent manner. It also reduces T-type Ca2+ currents in HEK cells transfected with human recombinant Cav3.1 channels at a concentration of 300 μM.

Uses

Carisbamate is being developed for adjuvant treatment of partial onset epilepsy. Carisbamate produces anticonvulsant effects in primary generalized, complex partial and absence-type seizure models, and exhibits neuroprotective and antiepileptogenic properties in rodent epilepsy models.

Uses

Labelled Carisbamate; it is being developed for adjuvant treatment of partial onset epilepsy. Carisbamate produces anticonvulsant effects in primary generalized, complex partial and absence-type seizu re models, and exhibits neuroprotective and antiepileptogenic properties in rodent epilepsy models.

Definition

ChEBI: Carisbamate is an organochlorine compound.

2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE Suppliers

Canada 1 China 22 India 1 United States 5 Global 29
J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Chemsky（shanghai）International Co.,Ltd.
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021-50135380
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shchemsky@sina.com
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Shanghai Fuhe Chemistry Technology Co., Ltd.
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0086-21-67651709
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0086-21-67651705
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China
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Cato Research Chemicals Inc.
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020-81960175
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BOC Sciences
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United States
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Shanghai EFE Biological Technology Co., Ltd.
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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Jinan Carbotang Biotech Co.,Ltd.
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AFINE CHEMICALS LIMITED
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008657185134895
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Hubei Jusheng Technology Co.,Ltd.
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18871490254
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027-59599243
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linda@hubeijusheng.com
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CHINA
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28172
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194085-75-1, 2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATERelated Search:


  • 2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE
  • Carisbamate
  • (S)-Carisbamate
  • 1,2-Ethanediol,1-(2-chlorophenyl)-, 2-carbaMate, (1S)-
  • JNJ 10234094
  • RWJ 333369
  • YKP 509
  • CarisbaMate (RWJ-333369)
  • [(2S)-2-(2-chlorophenyl)-2-hydroxyethyl] carbamate
  • 1,2-ETHANEDIOL,1-(2-CHLOROPHENYL)-, 2-CARBAMATE, (S)-
  • 194085-75-1
  • C813CH8D2Cl15NO3
  • Amines
  • Aromatics
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Isotope Labelled Compounds
  • Pharmaceuticals