6-OH-BTA-1

Product Name: 6-OH-BTA-1
CAS No.: 566169-93-5
Chemical Name: 6-OH-BTA-1
Synonyms: Pittsburgh Compound-B;6-OH-BTA-1;PiB, 10 mM in DMSO;6-OH-BTA-1 (free base);6-OH-BTA-1(free base)566169-93-5;2-[4-(Methylamino)-phenyl]-6-benzothiazolol;6-Benzothiazolol, 2-[4-(methylamino)phenyl]-;2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol;2-[4-(Methylamino)phenyl]-1,3-benzothiazol-6-ol;2-[4''-(Methylamino)phenyl]-6-hydroxybenzothiazole
CBNumber: CB11484156
Molecular Formula: C14H12N2OS
Formula Weight: 256.32288
MOL File: 566169-93-5.mol

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6-OH-BTA-1 Property

Boiling point:: 475.7±51.0 °C(Predicted)
Density: 1.353±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 8.74±0.40(Predicted)
InChI: InChI=1S/C14H12N2OS/c1-15-10-4-2-9(3-5-10)14-16-12-7-6-11(17)8-13(12)18-14/h2-8,15,17H,1H3
InChIKey: ZQAQXZBSGZUUNL-UHFFFAOYSA-N
SMILES: S1C2=CC(O)=CC=C2N=C1C1=CC=C(NC)C=C1
CAS DataBase Reference: 566169-93-5

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Safety

HS Code: 2934208090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

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N-Bromosuccinimide Price

Crysdot

Product number: CD11103314
Product name: 2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol
Purity: 95+%
Packaging: 100mg
Price: $232
Updated: 2021/12/16

Chemenu

Product number: CM147936
Product name: 2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol
Purity: 95%
Packaging: 100mg
Price: $234
Updated: 2021/12/16

Alichem

Product number: 566169935
Product name: 2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol
Packaging: 100mg
Price: $245.7
Updated: 2021/12/16

Crysdot

Product number: CD11103314
Product name: 2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol
Purity: 95+%
Packaging: 250mg
Price: $371
Updated: 2021/12/16

Alichem

Product number: 566169935
Product name: 2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol
Packaging: 250mg
Price: $371.25
Updated: 2021/12/16

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6-OH-BTA-1 Chemical Properties,Usage,Production

Chemical Properties

Yellow solid

Uses

Pittsburgh Compound B (PiB) is a PET tracer for Aβ deposition in Alzheimer's disease (AD), with high affinity and specificity. Through click chemistry modification (introducing a PEG3 linker and an alkyne group at the 6-hydroxy position of Pittsburgh Compound B to generate a clickable Pittsburgh Compound B derivative, followed by covalent conjugation with azide-labeled fluorescent dyes or affinity tags via copper-catalyzed azide-alkyne cycloaddition (CuAAC)), Pittsburgh Compound B and its conjugates can be used for fluorescence imaging, ultrastructural studies, and the enrichment and characterization of Aβ complexes. Pittsburgh Compound B holds great potential in Alzheimer's disease research[1].

Synthesis

401813-34-1

566169-93-5

BBr3 (1.0 M in CH2Cl2, 10.5 mL, 10.5 mmol) was slowly added dropwise to a solution of 2-[4-(N-monomethyl)aminophenyl]-6-methoxybenzothiazole (44,588 mg, 2.06 mmol) dissolved in dichloromethane (25 mL). The reaction mixture was stirred continuously for 12 hours at room temperature. Upon completion of the reaction, water and aqueous sodium bicarbonate were carefully added to quench the reaction, followed by extraction of the organic phase with dichloromethane. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 2-[4-(N-monomethyl)aminophenyl]-6-hydroxybenzothiazole (45,530 mg, 99% yield) as a yellow solid, which did not require further purification. The structure of the product was confirmed by 1H NMR (200 MHz, DMSO-d6) and 13C NMR (100 MHz, DMSO-d6).

References

[1] Diner I, et al. Generation of Clickable Pittsburgh Compound B for the Detection and Capture of β-Amyloid in Alzheimer's Disease Brain. Bioconjug Chem. 2017 Oct 18;28(10):2627-2637. DOI:10.1021/acs.bioconjchem.7b00500

6-OH-BTA-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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6-OH-BTA-1 Suppliers

China 46 Germany 1 India 1 United States 6 Global 54

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566169-93-5, 6-OH-BTA-1Related Search:

6-Benzothiazolol, 2-[4-(methylamino)phenyl]-

6-OH-BTA-1

6-Benzothiazolol, 2-[4-(methylamino)phenyl]-hydrochloride

6-OH-BTA-1 (free base)

2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol

6-OH-BTA-1(free base)566169-93-5

2-[4''-(Methylamino)phenyl]-6-hydroxybenzothiazole

2-[4-(Methylamino)phenyl]-1,3-benzothiazol-6-ol

2-[4-(Methylamino)-phenyl]-6-benzothiazolol

Pittsburgh Compound-B

PiB, 10 mM in DMSO

566169-93-5

C14H12N2OSHCl