5-(BROMOMETHYL)-3-METHYLISOXAZOLE

Product Name: 5-(BROMOMETHYL)-3-METHYLISOXAZOLE
CAS No.: 36958-61-9
Chemical Name: 5-(BROMOMETHYL)-3-METHYLISOXAZOLE
Synonyms: 5-(BROMOMETHYL)-3-METHYLISOXAZOLE;5-(Bromomethyl)-3-methylisoxazole95%;Isoxazole, 5-(broMoMethyl)-3-Methyl-;5-(Bromomethyl)-3-methyl-1,2-oxazole;5-(Bromomethyl)-3-methylisoxazole 95%
CBNumber: CB11486882
Molecular Formula: C5H6BrNO
Formula Weight: 176.01
MOL File: 36958-61-9.mol

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5-(BROMOMETHYL)-3-METHYLISOXAZOLE Property

Boiling point:: 67-68 °C(Press: 2 Torr)
Density: 1.4838 g/cm3
storage temp.: Inert atmosphere,Store in freezer, under -20°C
pka: -2.18±0.10(Predicted)
form: liquid
color: Pale yellow
CAS DataBase Reference: 36958-61-9

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Safety

Hazard Codes: C,Xn
Risk Statements: 22-36
Safety Statements: 26
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B847125
Product name: 5-(Bromomethyl)-3-methylisoxazole
Packaging: 50mg
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: OR15946
Product name: 5-(Bromomethyl)-3-methylisoxazole
Purity: 95%
Packaging: 250mg
Price: $66
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H44-9-X1
Product name: 5-(Bromomethyl)-3-methylisoxazole
Purity: 95%
Packaging: 250mg
Price: $72
Updated: 2021/12/16

AK Scientific

Product number: Y8895
Product name: 5-(Bromomethyl)-3-methylisoxazole
Packaging: 250mg
Price: $109
Updated: 2021/12/16

Matrix Scientific

Product number: 130050
Product name: 5-Bromomethyl-3-methyl-isoxazole
Purity: 95%+
Packaging: 500mg
Price: $137
Updated: 2021/12/16

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5-(BROMOMETHYL)-3-METHYLISOXAZOLE Chemical Properties,Usage,Production

Synthesis

107-29-9

106-96-7

36958-61-9

To a stirred solution of acetaldoxime (10 g, 169.49 mmol) in dichloromethane (DCM, 200 mL) was added 3-bromopropargyl (13 mL, 169.49 mmol) followed by triethylamine (10 mL) at 0 °C. Then, 4% aqueous sodium hypochlorite solution (NaOCl, 1.08 mL) was added dropwise to the reaction mixture. The reaction mixture was stirred at 0 °C and then gradually warmed up to room temperature and continued stirring for 3 hours. After completion of the reaction, the reaction mixture was extracted with dichloromethane (3 x 200 mL), the organic phases were combined and dried with anhydrous sodium sulfate (Na2SO4). The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by fast column chromatography (silica gel: 100-200 mesh), the eluent was 0-10% ethyl acetate (EtOAc) in hexane solution, and the final product was 5-(bromomethyl)-3-methylisoxazole (3 g, 11.2%) as a light yellow liquid. The structure of the product was confirmed by 1H-NMR (CDCl3, 400 MHz) with chemical shifts (ppm) of 6.18 (s, 1H), 4.42 (s, 2H), 2.31 (s, 3H).

References

[1] Patent: WO2015/40162, 2015, A1. Location in patent: Page/Page column 140-141

5-(BROMOMETHYL)-3-METHYLISOXAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(BROMOMETHYL)-3-METHYLISOXAZOLE Suppliers

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36958-61-9, 5-(BROMOMETHYL)-3-METHYLISOXAZOLERelated Search:

5-(Bromomethyl)-3-phenylisoxazole ETHYL 5-(BROMOMETHYL)ISOXAZOLE-3-CARBOXYLATE 5-BROMOMETHYL-3-P-TOLYL-ISOXAZOLE 5-(BROMOMETHYL)-3-METHYLISOXAZOLE 5-BROMOMETHYL-3-(3-CHLORO-PHENYL)-ISOXAZOLE 5-BROMOMETHYL-3-(4-BROMO-PHENYL)-ISOXAZOLE 5-BROMOMETHYL-3-(2-BROMO-PHENYL)-ISOXAZOLE 5-(BROMOMETHYL)-3-(4-METHOXYPHENYL)ISOXAZOLE 5-(BROMOMETHYL)-3-(2-METHOXYPHENYL)ISOXAZOLE 5-BROMOMETHYL-3-(4-FLUORO-PHENYL)-ISOXAZOLE 5-(BROMOMETHYL)-3-(4-CHLOROPHENYL)ISOXAZOLE ALLYL 5-(BROMOMETHYL)ISOXAZOLE-3-CARBOXYLATE 5-BROMOMETHYL-3-(2-TRIFLUOROMETHYL-PHENYL)-ISOXAZOLE 5-BROMOMETHYL-3-(2-TRIFLUOROMETHOXY-PHENYL)-ISOXAZOLE 5-(BROMOMETHYL)-3-(2,4-DICHLOROPHENYL)ISOXAZOLE 5-BROMOMETHYL-3-(3,4-DIMETHYL-PHENYL)-ISOXAZOLE 5-BROMOMETHYL-3-(2-CHLORO-PHENYL)-ISOXAZOLE 4-(5-BROMOMETHYL-ISOXAZOL-3-YL)-PHENYLAMINE

5-(Bromomethyl)-3-methyl-1,2-oxazole

Isoxazole, 5-(broMoMethyl)-3-Methyl-

5-(Bromomethyl)-3-methylisoxazole95%

5-(BROMOMETHYL)-3-METHYLISOXAZOLE

5-(Bromomethyl)-3-methylisoxazole 95%

36958-61-9