4-(4-BROMO-PHENOXY)-BUTYRIC ACID
- Product Name
- 4-(4-BROMO-PHENOXY)-BUTYRIC ACID
- CAS No.
- 55580-07-9
- Chemical Name
- 4-(4-BROMO-PHENOXY)-BUTYRIC ACID
- Synonyms
- 4-(4-Bromophenoxy);4-(p-BroMophenoxy)buttersaeure;Butanoic acid, 4-(4-bromophenoxy)-;JR-8186, 4-(4-Bromophenoxy)butanoic acid, 97%
- CBNumber
- CB11489247
- Molecular Formula
- C10H11BrO3
- Formula Weight
- 259.1
- MOL File
- 55580-07-9.mol
4-(4-BROMO-PHENOXY)-BUTYRIC ACID Property
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- Appearance
- White to off-white Solid
N-Bromosuccinimide Price
- Product number
- JRD1063
- Product name
- 4-(4-Bromophenoxy)butanoic acid
- Packaging
- 1G
- Price
- $259
- Updated
- 2025/07/31
- Product number
- FB54217
- Product name
- 4-(4-Bromophenoxy)butanoic acid
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-0059799
- Product name
- 4-(4-Bromophenoxy)butanoicacid
- Packaging
- 5g
- Price
- $83
- Updated
- 2021/12/16
- Product number
- FB54217
- Product name
- 4-(4-Bromophenoxy)butanoic acid
- Packaging
- 500mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-0059799
- Product name
- 4-(4-Bromophenoxy)butanoicacid
- Packaging
- 10g
- Price
- $140
- Updated
- 2021/12/16
4-(4-BROMO-PHENOXY)-BUTYRIC ACID Chemical Properties,Usage,Production
Synthesis
157245-87-9
55580-07-9
Step 2: The crude product 4-(4-bromophenoxy)butyric acid ethyl ester obtained in step 1 was dissolved in methanol (100 mL) and 3N aqueous sodium hydroxide solution (200 mL) was added. The reaction mixture was heated to 70 °C and kept for 1 hour for hydrolysis reaction. Upon completion of the reaction, the mixture was poured into ice water and 37% aqueous hydrochloric acid (50 mL) was slowly added to neutralize the reaction system. The mixture was extracted with ethyl acetate, the organic phases were combined, washed with water and dried over anhydrous sodium sulfate. The solvent was removed by evaporation under reduced pressure to give the crude product. The crude product was ground with ether to give 4-(4-bromophenoxy)butyric acid (41 g, 79% yield, two steps) as a white solid.1H NMR (500 MHz, CDCl3) δ ppm: 2.12-2.16 (m, 2H), 2.61 (t, J = 7.0 Hz, 2H), 4.02 (t, J = 6.0 Hz, 2H), 6.78 (d,. J = 9.0 Hz, 2H), 7.39 (d, J = 9.0 Hz, 2H).
References
[1] Journal of Medicinal Chemistry, 2000, vol. 43, # 10, p. 2049 - 2063
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 2, p. 914 - 923
[3] Patent: WO2016/25932, 2016, A1. Location in patent: Page/Page column 150; 151
[4] Chemistry - A European Journal, 2016, vol. 22, # 29, p. 9971 - 9974
4-(4-BROMO-PHENOXY)-BUTYRIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
4-(4-BROMO-PHENOXY)-BUTYRIC ACID Suppliers
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