3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE

Product Name: 3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
CAS No.: 350997-39-6
Chemical Name: 3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
Synonyms: OGG1-IN-08;OGG1-IN-O8;O8 OGG1 Inhibitor;OGG1 Inhibitor O8;OGG1 Inhibitor O8 >=98% (HPLC);3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide;3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE;Benzo[b]thiophene-2-carboxylic acid, 3,4-dichloro-, hydrazide;Inhibitor,inhibit,OGG1,FapyGua,OGG1IN08,glycosylase,AP site,OGG1 IN 08,lyase,OGG-1-IN-08
CBNumber: CB11499417
Molecular Formula: C9H6Cl2N2OS
Formula Weight: 261.13
MOL File: 350997-39-6.mol

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3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE Property

Density: 1.587±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF: 5mg/mL; DMSO: 10mg/mL; DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL
form: powder
pka: 11.75±0.30(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1697
Product name: OGG1 Inhibitor O8
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $105
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1697
Product name: OGG1 Inhibitor O8
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $424
Updated: 2023/06/20

Cayman Chemical

Product number: 29769
Product name: OGG1-IN-O8
Packaging: 5mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 29769
Product name: OGG1-IN-O8
Packaging: 25mg
Price: $330
Updated: 2024/03/01

Cayman Chemical

Product number: 29769
Product name: OGG1-IN-O8
Packaging: 1mg
Price: $34
Updated: 2024/03/01

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3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE Chemical Properties,Usage,Production

Uses

O8 OGG1 Inhibitor is potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 0.2 μM in a gel based assay). Exhibits > 200-fold selectivity for OGG1 over other DNA glycosylases, NEIL1 and NTH1.

General Description

Inhibition of 8-oxoguanine DNA glycosylase-1 (OGG1) can be used in monotherapy or in combination therapy to treat some types of cancer.

Biochem/physiol Actions

OGG1 Inhibitor O8 is a potent inhibitor of 8-Oxoguanine DNA Glycosylase-1 (OGG1), part of the DNA base excision repair (BER) pathway that is becoming a drug target for cancer therapy. OGG1 Inhibitor O8 has an IC50 value of 220 nM and >100-fold selectivity for OGG1 relative to several other DNA repair glycosylases. O8 acts through the inhibition of Schiff base formation during OGG1 catalysis. It does not prevent DNA binding of OGG1 to a 7,8-dihydro-8-oxoguanine (8-oxo-Gua)-containing substrate.

storage

Store at +4°C

3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE Suppliers

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350997-39-6, 3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDERelated Search:

ANTI-ESTROGEN RECEPTOR Ethylamine (-)-Varitriol

3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE

OGG1 Inhibitor O8

O8 OGG1 Inhibitor

3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide

OGG1-IN-O8

OGG1 Inhibitor O8 >=98% (HPLC)

OGG1-IN-08

Inhibitor,inhibit,OGG1,FapyGua,OGG1IN08,glycosylase,AP site,OGG1 IN 08,lyase,OGG-1-IN-08

Benzo[b]thiophene-2-carboxylic acid, 3,4-dichloro-, hydrazide

350997-39-6