ChemicalBook > CAS DataBase List > 3,5-Difluoro-4-pyridinecarboxaldehyde

3,5-Difluoro-4-pyridinecarboxaldehyde

Uses

Product Name: 3,5-Difluoro-4-pyridinecarboxaldehyde
CAS No.: 870234-98-3
Chemical Name: 3,5-Difluoro-4-pyridinecarboxaldehyde
Synonyms: 2,6-difluoroisonicotinaldehyde;3,5-Difluoroisonicotinaldehyde 98%;3,5-Difluoro-4-pyridinecarboxaldehyde;4-Pyridinecarboxaldehyde, 3,5-difluoro-;3,5-difluoropyridine-4-carbaldehyde - [D87647];(5-fluoro-4-(methylsulfonyl)pyridin-3-yl)boronic acid;3,5-Difluoro-4-pyridinecarboxaldehyde ISO 9001：2015 REACH;3,5-Difluoropyridine-4-carboxaldehyde, 3,5-Difluoro-4-formylpyridine;3,5-Difluoropyridine-4-carboxaldehyde 3,5-Difluoro-4-pyridinecarboxaldehyde
CBNumber: CB11501367
Molecular Formula: C6H3F2NO
Formula Weight: 143.09
MOL File: 870234-98-3.mol

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3,5-Difluoro-4-pyridinecarboxaldehyde Property

Melting point:: 51-52℃
Boiling point:: 169℃
Density: 1.392
Flash point:: 56℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.60±0.28(Predicted)
Appearance: Light yellow to yellow Solid
InChI: InChI=1S/C6H3F2NO/c7-5-1-9-2-6(8)4(5)3-10/h1-3H
InChIKey: RLAOKDGTZKSUJB-UHFFFAOYSA-N
SMILES: C1=NC=C(F)C(C=O)=C1F

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: D234980
Product name: 3,5-Difluoroisonicotinaldehyde
Packaging: 500mg
Price: $220
Updated: 2021/12/16

AK Scientific

Product number: Y4412
Product name: 3,5-Difluoropyridine-4-carbaldehyde
Packaging: 1g
Price: $251
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: D1694
Product name: 3,5-Difluoro-4-formylpyridine
Purity: 98%
Packaging: 5g
Price: $450
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD32269
Product name: 3,5-Difluoro-4-pyridinecarboxaldehyde
Packaging: 1g
Price: $525
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0004101
Product name: 3,5-DIFLUORO PYRIDINE-4-CARBOXALDEHYDE
Purity: 95.00%
Packaging: 500MG
Price: $553
Updated: 2021/12/16

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3,5-Difluoro-4-pyridinecarboxaldehyde Chemical Properties,Usage,Production

Uses

3,5-Difluoropyridine-4-carboxaldehyde is an aldehyde organic compound that can be used as a pharmaceutical intermediate.

Synthesis

107-31-3

71902-33-5

870234-98-3

General procedure for the synthesis of 3,5-difluoropyridine-4-carbaldehyde from methyl formate and 3,5-difluoropyridine: Preparation of Example 10: N-[(3,5-difluoro-4-pyridinyl)methyl]-2-(trifluoromethyl)pyridine-3-carboxamide (Compound A126) Step 1: Synthesis of 3,5-difluoropyridine-4-carbaldehyde A 2M solution of LDA (47.792 mL, 95.58 mmol) was diluted with 50 mL of THF at 0°C and cooled to -78°C. Subsequently, a 100 mL THF solution of 3,5-difluoropyridine (7.886 mL, 86.89 mmol) was added dropwise, keeping the temperature lower than -70°C (the dropwise addition process was controlled to be completed within 20 min). The reaction mixture formed a yellow suspension. Stirring was continued at -78°C for 3 hours. Then, 25 mL of THF solution of methyl formate (10.8 mL, 173.79 mmol) was added and the reaction mixture was transformed into a light yellow solution and stirred at -75°C for 45 minutes. The reaction mixture was transferred by cannula to 100 mL of stirred saturated aqueous NaHCO3 solution, maintained at about 0°C. The solution was extracted with EtOAc, the organic phases were combined and washed with brine and dried with 1N HCl. The solvent was evaporated at 165 mbar, 30°C to give 36.7 g of yellow liquid crude product. The crude product was purified by fast chromatography (eluent: CH2Cl2) to give a light yellow oil (7.85 g), which was crystallized after standing. 1H-NMR (CDCl3) data: δ 10.4 (s, 1H), 8.57 (s, 2H).

References

[1] Patent: US2014/128386, 2014, A1. Location in patent: Paragraph 1410; 1411; 1412; 1413; 1414
[2] Patent: US2017/57954, 2017, A1. Location in patent: Paragraph 0630; 0631; 0632; 0633; 0634
[3] Patent: US2009/286800, 2009, A1. Location in patent: Page/Page column 107-108
[4] Patent: WO2013/64521, 2013, A1. Location in patent: Page/Page column 112
[5] Patent: US2017/217954, 2017, A1

3,5-Difluoro-4-pyridinecarboxaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,5-Difluoro-4-pyridinecarboxaldehyde manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3,5-Difluoro-4-pyridinecarboxaldehyde 870234-98-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Career Henan Chemical Co

Product: 3,5-Difluoro-4-pyridinecarboxaldehyde 870234-98-3
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%MIN
Supply Ability: ASK
Release date: 2019-12-24

870234-98-3, 3,5-Difluoro-4-pyridinecarboxaldehydeRelated Search:

2-Pyridinecarboxaldehyde,3,5-dimethyl-(9CI) (3,5-DIFLUOROPYRIDIN-4-YL)BORONIC ACID 3,5-Dichloro-4-Methoxy-pyridine 3,5-DIAMINOBENZONITRILE 3,5-DIBROMO-4-PYRIDINOL 3,5-Dichloro-4-hydroxypyridine 3,5-Dichloro-2(1H)-pyrazinone ETHYL 3,5-DIBROMOISONICOTINATE 2-Pyridinecarboxylicacid,3,5-dimethyl-(9CI) 3,5-DIBROMO-4-METHOXYPYRIDINE-N-OXIDE 3,5-Difluoroisonicotinic acid 3,5-Difluoro-4-pyridinecarboxaldehyde 2,6-DIBROMO-3,5-DIFLUOROISONICOTINIC ACID 2,3,5-TRIFLUOROPYRIDINE-4-CARBOXYLIC ACID, 97 2,3,5,6-TETRAFLUOROPYRIDINE-4-CARBOXYLIC ACID 2-AMINO-3,5,6-TRIFLUORO-PYRIDINE-4-CARBOXAMIDE 2-Amino-3,5,6-trifluoro-4-pyridinecarboxylicacidethylester 2,3,5-TRIFLUOROPYRIDINE-4-CARBOXALDEHYDE

3,5-Difluoro-4-pyridinecarboxaldehyde

3,5-Difluoropyridine-4-carboxaldehyde, 3,5-Difluoro-4-formylpyridine

3,5-Difluoropyridine-4-carboxaldehyde 3,5-Difluoro-4-pyridinecarboxaldehyde

2,6-difluoroisonicotinaldehyde

3,5-Difluoroisonicotinaldehyde 98%

4-Pyridinecarboxaldehyde, 3,5-difluoro-

3,5-Difluoro-4-pyridinecarboxaldehyde ISO 9001：2015 REACH

(5-fluoro-4-(methylsulfonyl)pyridin-3-yl)boronic acid

3,5-difluoropyridine-4-carbaldehyde - [D87647]

870234-98-3

organic building block

pharmacetical

Fluorinated

Organohalides

Pyridine