ChemicalBook > CAS DataBase List > 3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE

3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE

Product Name
3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE
CAS No.
96901-92-7
Chemical Name
3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE
Synonyms
3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE;8-Azabicyclo[3.2.1]octan-3-amine, 8-(phenylmethyl)-;3-(endo-amino)-8-(phenylmethyl)-8-azabicyclo[3.2.1]octane;8-benzyl-8-azabicyclo[3.2.1]octan-3-amine, Mixture of diastereomers
CBNumber
CB11504050
Molecular Formula
C14H20N2
Formula Weight
216.32
MOL File
96901-92-7.mol
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3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE Property

storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific
Product number
5656BB
Product name
8-Benzyl-8-azabicyclo[3.2.1]octan-3-amine
Packaging
2.5g
Price
$1109
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0114385
Product name
8-BENZYL-8-AZABICYCLO[3.2.1]OCTAN-3-AMINE
Purity
95.00%
Packaging
1G
Price
$1434.67
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0114385
Product name
8-BENZYL-8-AZABICYCLO[3.2.1]OCTAN-3-AMINE
Purity
95.00%
Packaging
2.5G
Price
$2314.44
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0114385
Product name
8-BENZYL-8-AZABICYCLO[3.2.1]OCTAN-3-AMINE
Purity
95.00%
Packaging
5G
Price
$3236.4
Updated
2021/12/16
AK Scientific
Product number
5656BB
Product name
8-Benzyl-8-azabicyclo[3.2.1]octan-3-amine
Packaging
100mg
Price
$258
Updated
2021/12/16
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3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE Chemical Properties,Usage,Production

Synthesis

76272-34-9

96901-92-7

The general procedure for the synthesis of 8-benzyl-8-azabicyclo[3.2.1]octan-3-amine from 8-benzyl-8-azabicyclo[3.2.1]octan-3-one oxime is as follows: these amines are key intermediates in the synthesis of compounds 4 and 20. First, 1-methylpiperazine or piperidine (1 mmol) and triethylamine (1.5 mmol, 0.21 mL) were sequentially added to a solution of 4-nitrobenzyl chloride (1 mmol) in anhydrous THF (3 mL). The reaction mixture was stirred at 70 °C overnight. Upon completion of the reaction, it was separated by extraction with dichloromethane and water. The organic phases were combined, dried over anhydrous Na2SO4 and subsequently concentrated under reduced pressure. The residue was purified by column chromatography (eluent ratio hexane/ethyl acetate 1:4) and the structure was confirmed by 1H NMR (see Supplementary Information). The purified product was dissolved in 10 mL of ethanol and PtO2 (0.01 g) was added under nitrogen protection. The hydrogenation reaction was carried out for 16 h at 50 psi hydrogen pressure using a Parr hydrogenation unit. At the end of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under vacuum to give the target amine compound in quantitative yield.

References

[1] Patent: WO2004/54974, 2004, A2. Location in patent: Page 55
[2] European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 2917 - 2929
[3] Patent: EP1156045, 2001, A1
[4] Patent: EP1243268, 2002, A1
[5] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 18, p. 3994 - 4007

3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE Suppliers

China 8 Czech Republic 1 United States 1 Global 10
BePharm Ltd
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400-685-9117
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021-51816740
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market@bepharm.com
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China
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Abydos Scientific
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025-84767922 18936879710
Email
sales@abydoscientific.com
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China
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Jiangsu aikang biomedical research and development co., LTD
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025-58859352 13155353615
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qzhang@aikonchem.com
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China
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Lingyuan Bebiansen Biological Technology Co., Ltd
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18642120371
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2837458851@qq.com
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China
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7963
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Zhengzhou Converging Chemical Co. LTD
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0371-53399770 18037166334
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2853031800@qq.com
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China
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Henan Zhuofan Chemical Co. , Ltd.
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15638881523
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68825546@qq.com
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China
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2066
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Biosynth Biological Technology (Suzhou) Co Ltd
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51288865780
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sales@biosynth.com
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China
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6051
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XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.
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+8618950047208
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ellena@amitychem.com
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China
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43416
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96901-92-7, 3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANERelated Search:

Tropapride 5-Pyrimidinecarboxamide, 2-amino-N-(8-(p-fluorobenzyl)-3-beta-nortropa nyl)-4-methoxy-, monomaleate 2-Amino-N-(8-(o-chlorobenzyl)-3-beta-nortropanyl)-4-methoxy-5-pyrimidi necarboxamide 2-Amino-4-methoxy-N-(8-(p-methylbenzyl)-3-beta-nortropanyl)-5-pyrimidi necarboxamide 5-Pyrimidinecarboxamide, 2-amino-N-(8-benzyl-3-beta-nortropanyl)-4-met hoxy- 2-Amino-N-(8-(o-fluorobenzyl)-3-beta-nortropanyl)-4-methoxy-5-pyrimidi necarboxamide 5-Pyrimidinecarboxamide, N-(8-benzyl-3-beta-nortropanyl)-2-(dimethylam ino)-4-ethoxy-, monomaleate 2-Amino-4-methoxy-N-(8-(p-nitrobenzyl)-3-beta-nortropanyl)-5-pyrimidin ecarboxamide maleate 2-Amino-4-methoxy-N-(8-(m-methylbenzyl)-3-beta-nortropanyl)-5-pyrimidi necarboxamide 2-Amino-N-(8-benzyl-3-beta-nortropanyl)-4-ethoxy-5-pyrimidinecarboxami de maleate 5-Pyrimidinecarboxamide, 4-methoxy-N-(8-(phenylmethyl)-8-azabicyclo(3. 2.1)oct-3-yl)-, exo- 5-Pyrimidinecarboxamide, N-(8-benzyl-3-beta-nortropanyl)-2-(dimethylam ino)-4-methoxy-, monomaleate 2-Amino-4-methoxy-N-(8-(o-methylbenzyl)-3-beta-nortropanyl)-5-pyrimidi necarboxamide 5-Pyrimidinecarboxamide, N-(8-benzyl-3-beta-nortropanyl)-4-ethoxy-2-et hyl- 2-Amino-N-(8-(m-chlorobenzyl)-3-beta-nortropanyl)-4-methoxy-5-pyrimidi necarboxamide 5-Pyrimidinecarboxamide, 4-ethoxy-N-(8-(phenylmethyl)-8-azabicyclo(3.2 .1)oct-3-yl)-, exo- 2-Amino-N-(8-(p-chlorobenzyl)-3-beta-nortropanyl)-4-methoxy-5-pyrimidi necarboxamide Benzamide, 4-amino-5-bromo-N-(8-((4-ethylphenyl)methyl)-8-azabicyclo(3 .2.1)oct-3-yl)-2-methoxy-, exo-

  • 3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE
  • 3-(endo-amino)-8-(phenylmethyl)-8-azabicyclo[3.2.1]octane
  • 8-Azabicyclo[3.2.1]octan-3-amine, 8-(phenylmethyl)-
  • 8-benzyl-8-azabicyclo[3.2.1]octan-3-amine, Mixture of diastereomers
  • 96901-92-7