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Bromantane

Product Name
Bromantane
CAS No.
87913-26-6
Chemical Name
Bromantane
Synonyms
bromantane;bromantan;N-(4-bromophenyl)-2-adamantanamine;Boomantan;AKOS BB-9852;2-(4-BROMOPHENYL)AMINOADAMANTANE;N-(2-ADAMANTYL)-N-(4-BROMOPHENYL)AMINE;Bromantan/N-(2-ADAMANTYL)-N-(4-BROMOPHENYL)AMINE;N-(4-BroMophenyl)tricyclo[3.3.1.13,7]decan-2-aMine;Tricyclo[3.3.1.13,7]decan-2-aMine,N-(4-broMophenyl)-
CBNumber
CB1150889
Molecular Formula
C16H20BrN
Formula Weight
306.24
MOL File
87913-26-6.mol
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Bromantane Property

Melting point:
106-108°C
Boiling point:
404.8±28.0 °C(Predicted)
Density 
1.388±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
pka
3.97±0.20(Predicted)
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C16H20BrN/c17-14-1-3-15(4-2-14)18-16-12-6-10-5-11(8-12)9-13(16)7-10/h1-4,10-13,16,18H,5-9H2
InChIKey
LWJALJDRFBXHKX-UHFFFAOYSA-N
SMILES
C12CC3CC(CC(C3)C1NC1=CC=C(Br)C=C1)C2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24688
Product name
Bromantane
Purity
≥98%
Packaging
10mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
24688
Product name
Bromantane
Purity
≥98%
Packaging
25mg
Price
$56
Updated
2024/03/01
TRC
Product number
B678450
Product name
Bromantane
Packaging
5g
Price
$1455
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0098887
Product name
N-(2-ADAMANTYL)-N-(4-BROMOPHENYL)AMINE
Purity
95.00%
Packaging
5G
Price
$1722.11
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA03743
Product name
N-(2-Adamantyl)-N-(4-bromophenyl)-amine
Packaging
250mg
Price
$65
Updated
2021/12/16
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Bromantane Chemical Properties,Usage,Production

Description

Bromantane is an adamantine derivate that has a bromaniline side chain. It has been used therapeutically in Russia as a psychostimulant and anxiolytic. It have serotonergic, dopaminergic and limited noradrenergic actions,similar tomesocarb. Bromantane was first detected in 1996(Ayotte and Goudreault 1999), but due to juridical problems nine doping cases at the Atlanta Olympic Games were classified without consequences for the athletes. It was included in the IOC list of prohibited substances in September 1996,shortly after the Olympic Games.

Uses

N-(2-ADAMANTYL)-N-(4-BROMOPHENYL)AMINE is an adamantane derivative used as an anxiolytic agent.

Uses

Bromantane is a protectant, a substance that makes the body more stable under physical stress without increasing oxygen consumption. It has stimulant, anxiolytic and antifrail effects. It is able to increase endurance and work capacity under stressful and intense conditions.

Mechanism of action

The mechanism of bromantane action is based on the facility to increase the activity of the lower centers of the central nervous system (the hypothalamus nuclei, the reticular nuclei of the operculum, the hippocampus). It does not exert any expressed action on noradrenergic mediators, but implements the activation properties through the dopaminergic system. Bromantane strengthens GABA-ergic mediation, reducing gene expression, supervising synthesis of GABA-transporters, and functioning as a return capture mediator. A potentiality for central serotonin holding effects is also assumed.

Side effects

Bromantane is said to have no addictive potential, and research done thus far shows that it doesn’t have serious side effects. Some users have reported having experienced brain fog, depression, and fatigue after the use of Bromantane. Nonetheless, there hasn't been sufficient research on Bromantane. Most of the trials have been conducted on rodents; therefore, its safety in humans is still uncertain.

Metabolism

Bromantane, upon oral induction, is quickly but not fully absorbed from the gastrointestinal tract into the blood (bioavailability: 42%). It is quickly, and in large quantities, distributed over the tissues and organs, and is slowly eliminated from the body. Bromantane is highly lipophilic, is distributed into the lipids of brain and fat tissue and, finally, is deposited in adipose tissue. The speed of bromantane absorption from the gastrointestinal tract is much higher in women, so the half-life is respectively lower than in men. The time to achievement of the maximum concentration of blood bromantane is 2.75 hours in women, and 4.0 hours in men. The drug is metabolized in the liver, but its elimination occurs mostly through the adrenal gland. Bromantane metabolism is characterized mainly by hydroxylation in the 6th position of the adamantan cycle. All of the determined metabolites can be found in urine, even in two weeks after administration of bromantane (this last fact is important for doping control).

Bromantane Preparation Products And Raw materials

Raw materials

Preparation Products

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Bromantane Suppliers

Xi'an Lyna Bio-Tech Co., Ltd.
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China
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Chemsky(shanghai)International Co.,Ltd.
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shchemsky@sina.com
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50
Chizhou Kailong Import and Export Trade Co., Ltd.
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Fax
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Changzhou Hopschain Chemical Co.,Ltd.
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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13612807752
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Capot Chemical Co.,Ltd.
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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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Nanjing Meihao Pharmaceutical Technology Co., Ltd.
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meitaochem@126.com
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meitaochem@126.com
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Hebei Yanxi Chemical Co., Ltd.
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+8617531190177
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peter@yan-xi.com
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Zhejiang J&C Biological Technology Co.,Limited
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+1-2135480471 +1-2135480471
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AFINE CHEMICALS LIMITED
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+86-0571-85134551
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008657185134895
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sales@afinechem.com
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Guangzhou Dreampharm Biotechnology Co., Ltd.
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020-36607679 17825480238
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QQ 3008233717
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Chemwill Asia Co.,Ltd.
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chemwill_asia@126.com
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2710913286@.com
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Chongqing Chemdad Co., Ltd
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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Shanghai Jiegu Biotechnology Co., Ltd.
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021-51698675
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jiejiegroup@126.com
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4252
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ZHENGZHOU TAIFENG PHARMACEUTICAL CO.,LTD
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182-3786-0830 19913859908
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LGC Science (Shanghai) Ltd.
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17717235263
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cindy.yang@lgcgroup.com
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Shanghai Easy CDMO Co.,Ltd
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August@easycdmo.com
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Hubei De'ao Chemical Research Pharmaceutical Technology Co., Ltd
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Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd.
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025-66061636 18013972705
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Guangdong Wengjiang Chemical Reagent Co.,Ltd.
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Henan Tianfu Chemical Co.,Ltd.
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ATK CHEMICAL COMPANY LIMITED
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Hubei Lidu New Material Technology Co., Ltd
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Dorne Chemical Technology co. LTD
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Henan Bao Enluo International TradeCo.,LTD
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Hebei Miaoyin Technology Co.,Ltd
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Wuhan senwayer century chemical Co.,Ltd
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PT CHEM GROUP LIMITED
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Hebei Yinsheng Technology Co., Ltd.
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Shanghai Hao Zhun Biological Technology Co., Ltd.
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--
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View Lastest Price from Bromantane manufacturers

Wuhan Senwayer Century Chemical Co.,Ltd
Product
Bromantane 87913-26-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2022-12-01
Hebei Yanxi Chemical Co., Ltd.
Product
N-(4-bromophenyl)adamantan-2-amine 87913-26-6
Price
US $100.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
2 tons
Release date
2023-09-04
ARCTIC EXPORTS INC
Product
Bromantane 87913-26-6
Price
US $0.00/kg
Min. Order
10kg
Purity
99% purity
Supply Ability
1000 kg
Release date
2023-12-13

87913-26-6, BromantaneRelated Search:


  • 2-(4-BROMOPHENYL)AMINOADAMANTANE
  • AKOS BB-9852
  • N-(2-ADAMANTYL)-N-(4-BROMOPHENYL)AMINE
  • N-(4-bromophenyl)-2-adamantanamine
  • bromantan
  • bromantane
  • n-(4-bromophenyl)-tricyclo(3.3.1.1(sup3.7))decan-2-amin
  • Tricyclo[3.3.1.13,7]decan-2-aMine,N-(4-broMophenyl)-
  • N-(4-BroMophenyl)tricyclo[3.3.1.13,7]decan-2-aMine
  • Boomantan
  • Bromantan/N-(2-ADAMANTYL)-N-(4-BROMOPHENYL)AMINE
  • 87913-26-6
  • C16H20BrN
  • Adamantane derivatives
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals