methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoate
- Product Name
- methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoate
- CAS No.
- 872624-52-7
- Chemical Name
- methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoate
- Synonyms
- Methyl 2-amino-4-trifluoromethyl-5-iodobenzoate;methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoate;Methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoic acid;methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoate 97%;2-AMino-5-iodo-4-trifluoroMethyl-benzoic acid Methyl ester;Benzoic acid, 2-aMino-5-iodo-4-(trifluoroMethyl)-, Methyl ester;Benzoicacid, 2-amino-5-iodo-4-(trifluoromethyl)-, methyleste...;Benzoic acid, 2-amino-5-iodo-4-(trifluoromethyl)-, methyl ester (9CI, ACI)
- CBNumber
- CB11512367
- Molecular Formula
- C9H7F3INO2
- Formula Weight
- 345.06
- MOL File
- 872624-52-7.mol
methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoate Property
- Boiling point:
- 347.4±42.0 °C(Predicted)
- Density
- 1.863±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 0.72±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
N-Bromosuccinimide Price
- Product number
- CS-0039068
- Product name
- Methyl2-amino-4-trifluoromethyl-5-iodobenzoate
- Packaging
- 1g
- Price
- $53
- Updated
- 2021/12/16
- Product number
- Z5235
- Product name
- Methyl2-amino-5-iodo-4-(trifluoromethyl)benzoate
- Packaging
- 1g
- Price
- $127
- Updated
- 2021/12/16
- Product number
- HCH0369143
- Product name
- METHYL-2-AMINO-5-IODO-4-(TRIFLUOROMETHYL)BENZOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.79
- Updated
- 2021/12/16
- Product number
- 126116
- Product name
- Methyl2-amino-5-iodo-4-(trifluoromethyl)benzoate
- Purity
- >95%
- Packaging
- 1g
- Price
- $504
- Updated
- 2021/12/16
- Product number
- Z5235
- Product name
- Methyl2-amino-5-iodo-4-(trifluoromethyl)benzoate
- Packaging
- 10g
- Price
- $645
- Updated
- 2021/12/16
methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoate Chemical Properties,Usage,Production
Synthesis
61500-87-6
872624-52-7
Step 3: Preparation of methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoate; A solution of methyl 2-amino-4-(trifluoromethyl)benzoate (178 g, 812 mmol) in ethanol (3.3 L) was slowly added to a suspension in ethanol (5 L) containing iodine (206.1 g, 812 mmol) and silver(II) sulfate (253 g, 812 mmol). . The reaction was stirred at room temperature and under nitrogen protection for 2 hours. After completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and the pad was washed with ethanol (2 L). The filtrate and washings were combined and concentrated under reduced pressure at 40°C to remove the solvent. The resulting residue was dissolved in ethyl acetate (7.5 L) and washed sequentially with saturated sodium bicarbonate solution (3 x 1.5 L), water (3 x 1.5 L) and brine (2 L). The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoate as a light brown crystalline solid (276.0 g, 99% yield).
References
[1] Patent: WO2006/2342, 2006, A1. Location in patent: Page/Page column 56
[2] Patent: WO2006/108591, 2006, A1. Location in patent: Page/Page column 10; 66
[3] Chinese Chemical Letters, 2017, vol. 28, # 6, p. 1248 - 1251
[4] Patent: WO2013/38390, 2013, A1. Location in patent: Page/Page column 64; 65
[5] ChemMedChem, 2017, vol. 12, # 3, p. 197 - 201
methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoate Preparation Products And Raw materials
Raw materials
Preparation Products
methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoate Suppliers
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- United States
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View Lastest Price from methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoate manufacturers
- Product
- Methyl 2-aMino-5-iodo-4-(trifluoroMethyl)benzoate 872624-52-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-07