2'',3''-DIHYDRO-2''-OXOSPIRO-[PIPERIDINE-4,4''(1H'')-QUINAZOLINE

Product Name: 2'',3''-DIHYDRO-2''-OXOSPIRO-[PIPERIDINE-4,4''(1H'')-QUINAZOLINE
CAS No.: 635713-68-7
Chemical Name: 2'',3''-DIHYDRO-2''-OXOSPIRO-[PIPERIDINE-4,4''(1H'')-QUINAZOLINE
Synonyms: 1'H-Spiro[piperidine-4,4'-quinazolin]-2'(3'H)-one;Spiro[piperidine-4,4'(1'H)-quinazolin]-2'(3'H)-one;spiro[1,3-dihydroquinazoline-4,4'-piperidine]-2-one;1'H-spiro[piperidine-4,4'(1'H)-quinazolin]-2'(3'H)-one;2'',3''-DIHYDRO-2''-OXOSPIRO-[PIPERIDINE-4,4''(1H'')-QUINAZOLINE
CBNumber: CB11516769
Molecular Formula: C12H15N3O
Formula Weight: 217.27
MOL File: 635713-68-7.mol

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2'',3''-DIHYDRO-2''-OXOSPIRO-[PIPERIDINE-4,4''(1H'')-QUINAZOLINE Property

Boiling point:: 371.3±42.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 11.77±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: S683535
Product name: 1''H-Spiro[piperidine-4,4''-quinazolin]-2''(3''H)-one
Packaging: 50mg
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: 9702AB
Product name: 1'H-Spiro[piperidine-4,4'-quinazolin]-2'(3'H)-one
Packaging: 250mg
Price: $291
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0385672
Product name: 1'H-SPIRO[PIPERIDINE-4,4'-QUINAZOLIN]-2'(3'H)-ONE
Purity: 95.00%
Packaging: 5MG
Price: $496.54
Updated: 2021/12/16

AK Scientific

Product number: 9702AB
Product name: 1'H-Spiro[piperidine-4,4'-quinazolin]-2'(3'H)-one
Packaging: 1g
Price: $651
Updated: 2021/12/16

Abosyn

Product number: 61-2395
Product name: 1'H-Spiro[piperidine-4,4'-quinazolin]-2'(3'H)-one
Purity: 95%-98%
Packaging: 0.25g
Price: $615
Updated: 2021/12/16

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2'',3''-DIHYDRO-2''-OXOSPIRO-[PIPERIDINE-4,4''(1H'')-QUINAZOLINE Chemical Properties,Usage,Production

Synthesis

635713-67-6

635713-68-7

The general procedure for the synthesis of 1'H-spiro[piperidine-4,4'-quinazolin]-2'(3'H)-ones was carried out as follows, using 1-benzyl-1'H-spiro[piperidine-4,4'-quinazolin]-2'(3'H)-ones as starting material: 1-benzyl-1'H-spiro[piperidine-4,4'-quinazolin]-2'(3'H)-ones (1.00 g) were dissolved in degassed methanol (50 ml ), 6N hydrochloric acid (2.0 ml) was added followed by 10% palladium carbon catalyst (150 mg). The reaction mixture was placed in a Parr hydrogenation unit and the reaction was shaken at 60 psi hydrogen pressure overnight. The progress of the reaction was monitored by LC/MS and the reaction was found to be incomplete. The 10% palladium carbon catalyst (200 mg) was added additionally and the reaction was continued with oscillation under the same conditions for 2 days. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford the target product 1'H-spiro[piperidin-4,4'-quinazolin]-2'(3'H)-one (531 mg, 64% yield). Mass spectrometry analysis showed a molecular ion peak of 218.12 (MH+).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 14, p. 4719 - 4722
[2] Patent: WO2003/104236, 2003, A1. Location in patent: Page 58
[3] Patent: US2005/215576, 2005, A1. Location in patent: Page/Page column 19

2'',3''-DIHYDRO-2''-OXOSPIRO-[PIPERIDINE-4,4''(1H'')-QUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2'',3''-DIHYDRO-2''-OXOSPIRO-[PIPERIDINE-4,4''(1H'')-QUINAZOLINE Suppliers

China 30 Germany 1 India 1 United States 7 Global 39

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635713-68-7, 2'',3''-DIHYDRO-2''-OXOSPIRO-[PIPERIDINE-4,4''(1H'')-QUINAZOLINERelated Search:

1'H-Spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one 2'',3''-DIHYDRO-2''-OXOSPIRO-[PIPERIDINE-4,4''(1H'')-QUINAZOLINE N-Methyl-4-phenyl-4-piperidinamine

2'',3''-DIHYDRO-2''-OXOSPIRO-[PIPERIDINE-4,4''(1H'')-QUINAZOLINE

Spiro[piperidine-4,4'(1'H)-quinazolin]-2'(3'H)-one

1'H-Spiro[piperidine-4,4'-quinazolin]-2'(3'H)-one

1'H-spiro[piperidine-4,4'(1'H)-quinazolin]-2'(3'H)-one

spiro[1,3-dihydroquinazoline-4,4'-piperidine]-2-one

635713-68-7