ChemicalBook > CAS DataBase List > 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

Product Name
5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
CAS No.
66611-26-5
Chemical Name
5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
Synonyms
CS-1199;RU24969;RU 24969;RU 24969 free base;RU 24969, 10 mM in DMSO;5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole;3-(1,2,3,6-Tetrahydropyridine-4-yl)-5-methoxy-1H-indole;1H-Indole, 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-;5,6-dimethyl-2-(pyridin-4-yl)-2,3-dihydro-1H-benzo[d]imidazole;5-Methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole succinate;5-HT1B,Serotonin Receptor,fluid,RU 24969,5-HT1A,RU24969,locomotion,Inhibitor,5-HT Receptor,5-hydroxytryptamine Receptor,inhibit,RU-24969
CBNumber
CB11527037
Molecular Formula
C14H16N2O
Formula Weight
228.29
MOL File
66611-26-5.mol
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5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole Property

Melting point:
179-181 °C
Boiling point:
434.6±45.0 °C(Predicted)
Density 
1.174±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: ≥ 30 mg/mL (131.41 mM)
form 
Powder
pka
16.77±0.30(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-3218
Product name
RU24969
Purity
99.77%
Packaging
100mg
Price
$115
Updated
2021/12/16
ChemScene
Product number
CS-3218
Product name
RU24969
Purity
99.77%
Packaging
250mg
Price
$190
Updated
2021/12/16
ChemScene
Product number
CS-3218
Product name
RU24969
Purity
99.77%
Packaging
1g
Price
$380
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0006969
Product name
RU-24969
Purity
95.00%
Packaging
1G
Price
$453.6
Updated
2021/12/16
AK Scientific
Product number
7830CA
Product name
5-Methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
Packaging
250mg
Price
$586
Updated
2021/12/16
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5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole Chemical Properties,Usage,Production

Uses

RU 24969 is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 could decrease fluid consumption and increase forward locomotion[1].

Definition

ChEBI: 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole is a member of indoles.

in vivo

RU 24969 (0.03-3.0 mg/kg; s.c.) dose-dependently decreases water consumption in water deprived rats[1].
RU 24969 (0.3-3.0 mg/kg; s.c.) dose-dependently increases forward locomotion[1].

Animal Model:Male Sprague-Dawley rats[1]
Dosage:0.03, 0.3, 1.0, 3.0 mg/kg
Administration:A single s.c.
Result:Decreased water consumption significantly at dose of 0.3, 1.0, and 3.0 mg/kg.

IC 50

5-HT1B Receptor: 0.38 nM (Ki); 5-HT1A Receptor: 2.5 nM (Ki)

References

[1] Aronsen D, et, al. RU 24969-produced adipsia and hyperlocomotion: differential role of 5HT 1A and 5HT 1B receptor mechanisms. Pharmacol Biochem Behav. 2014 Sep; 124: 1-4. DOI:10.1016/j.pbb.2014.05.008
[2] Brazell MP, et, al. The 5-HT1 receptor agonist RU-24969 decreases 5-hydroxytryptamine (5-HT) release and metabolism in the rat frontal cortex in vitro and in vivo. Br J Pharmacol. 1985 Sep; 86(1): 209-16. DOI:10.1111/j.1476-5381.1985.tb09451.x

5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole Preparation Products And Raw materials

Raw materials

Preparation Products

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5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole Suppliers

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Shanghai Hanhong Scientific Co.,Ltd.
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66611-26-5, 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoleRelated Search:

3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)-1H-INDOLE 5-METHOXY-3-(1,2,5,6-TETRAHYDRO-4-PYRIDINYL)-1H-INDOLE HEMISUCCINATE 5-METHOXY-3-(1-METHYL-1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-1H-INDOLE 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

  • 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
  • 3-(1,2,3,6-Tetrahydropyridine-4-yl)-5-methoxy-1H-indole
  • 5-Methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole succinate
  • 5,6-dimethyl-2-(pyridin-4-yl)-2,3-dihydro-1H-benzo[d]imidazole
  • CS-1199
  • RU24969;RU 24969
  • 1H-Indole, 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-
  • 5-HT1B,Serotonin Receptor,fluid,RU 24969,5-HT1A,RU24969,locomotion,Inhibitor,5-HT Receptor,5-hydroxytryptamine Receptor,inhibit,RU-24969
  • RU 24969 free base
  • RU 24969, 10 mM in DMSO
  • 66611-26-5