4,5,6-TRIFLUOROPYRIMIDINE
- Product Name
- 4,5,6-TRIFLUOROPYRIMIDINE
- CAS No.
- 17573-78-3
- Chemical Name
- 4,5,6-TRIFLUOROPYRIMIDINE
- Synonyms
- 4,5,6-TRIFLUOROPYRIMIDINE;Pyrimidine,4,5,6-trifluoro-;4,5,6-Trifluoro-1,3-diazine;Pyrimidine, 4,5,6-trifluoro- (8CI,9CI);4,5,6-TRIFLUOROPYRIMIDINE ISO 9001：2015 REACH
- CBNumber
- CB1154928
- Molecular Formula
- C4HF3N2
- Formula Weight
- 134.06
- MOL File
- 17573-78-3.mol
4,5,6-TRIFLUOROPYRIMIDINE Property
- Boiling point:
- 83-85°C
- Density
- 1.4609
- refractive index
- 1.4087
- Flash point:
- 83-85°C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Acetone, Chloroform, Methanol (Slightly)
- form
- Oil
- pka
- -6.10±0.26(Predicted)
- color
- Clear Colourless to Light Yellow
- CAS DataBase Reference
- 17573-78-3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H314Causes severe skin burns and eye damage
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- T792710
- Product name
- 4,5,6-Trifluoropyrimidine
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- PC7842
- Product name
- 4,5,6-Trifluoropyrimidine
- Packaging
- 250mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 3H32-3-64
- Product name
- 4,5,6-Trifluoropyrimidine
- Packaging
- 250mg
- Price
- $44
- Updated
- 2021/12/16
- Product number
- 011226
- Product name
- 4,5,6-Trifluoropyrimidine
- Purity
- 96%
- Packaging
- 500mg
- Price
- $89
- Updated
- 2021/12/16
- Product number
- 5875AD
- Product name
- 4,5,6-Trifluoropyrimidine
- Packaging
- 250mg
- Price
- $99
- Updated
- 2021/12/16
4,5,6-TRIFLUOROPYRIMIDINE Chemical Properties,Usage,Production
Uses
4,5,6-Trifluoropyrimidine is a starting material for the preparation of O-linked pyrimidinamine-based compounds as deoxycytidine kinase inhibitors. These inhibitors are useful for treatment of cancer.
Synthesis
1780-27-4
17573-78-3
The general procedure for the synthesis of 4,5,6-trifluoropyrimidine from 4,5,6-trichloropyrimidine was as follows: first, 7160 mL of cyclobutanesulfone and 3876 g of potassium fluoride (KF) were added to an autoclave and stirred for 1 hour at 150 °C. Subsequently, 700 mL of the cyclobutanesulfone was removed by reduced pressure distillation to dry the mixture. The mixture was cooled to 90 °C and the air in the kettle was replaced with nitrogen. Next, a solution of 3122 g of 4,5,6-trichloropyrimidine and 2386 g of dried cyclobutanesulfone preheated to 45 °C was added. The reaction vessel was sealed after the rapid addition of 10 g of CNC catalyst and 20.5 g of nitrobenzene. The mixture was heated to 200 °C and the reaction was stirred for 5 hours, then warmed to 220 °C to continue the reaction for 11 hours. The maximum total pressure was controlled at 6.5 bar during the reaction. Upon completion of the reaction, the mixture was cooled to 40 °C with stirring and the product was slowly depressurized and transferred to an ice-cold receiver. Subsequently, the internal temperature was slowly raised to 150 °C and the product was distilled first at atmospheric pressure and then at reduced pressure. Redistillation of the crude product gave 1540 g of 4,5,6-trifluoropyrimidine (66% of theoretical yield) as a colorless liquid.
References
[1] Patent: US2006/9643, 2006, A1. Location in patent: Page/Page column 5
4,5,6-TRIFLUOROPYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,5,6-TRIFLUOROPYRIMIDINE manufacturers
- Product
- 4,5,6-TRIFLUOROPYRIMIDINE 17573-78-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 4,5,6-TRIFLUOROPYRIMIDINE 17573-78-3
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08