3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid

Product Name: 3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid
CAS No.: 851202-96-5
Chemical Name: 3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid
Synonyms: 3,4-Dihydro-2H-benzo[1,4]...;3,4-dihydro-2H-1,4-benzoxazine-7-carboxylic acid;3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid;2H-1,4-Benzoxazine-7-carboxylic acid, 3,4-dihydro-;3,4-Dihydro-2H-benzo[b][1,4]oxazine-7-carboxylic acid
CBNumber: CB11558644
Molecular Formula: C9H9NO3
Formula Weight: 179.17
MOL File: 851202-96-5.mol

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3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid Property

Boiling point:: 385.2±42.0 °C(Predicted)
Density: 1.318±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 4.80±0.20(Predicted)
Appearance: Yellow to brown Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D451435
Product name: 3,4-Dihydro-2H-1,4-benzoxazine-7-carboxylicacid
Packaging: 250mg
Price: $180
Updated: 2021/12/16

AK Scientific

Product number: 3164AC
Product name: 3,4-Dihydro-2H-benzo[b][1,4]oxazine-7-carboxylicacid
Packaging: 250mg
Price: $344
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0098388
Product name: 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE-7-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $498.06
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-WF
Product name: 3,4-Dihydro-2H-1,4-benzoxazine-7-carboxylic acid
Purity: 97.0%
Packaging: 250mg
Price: $540
Updated: 2021/12/16

Matrix Scientific

Product number: 122396
Product name: 3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylicacid
Purity: 97.0%
Packaging: 1g
Price: $1188
Updated: 2021/12/16

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3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid Chemical Properties,Usage,Production

Synthesis

142166-01-6

851202-96-5

The general procedure for the synthesis of 3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylic acid from methyl 3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate was as follows: methyl 3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylate (52 mmol) was dissolved in methanol (20 mL) and 2M aqueous sodium hydroxide (20 mL). The reaction was stirred at 60 °C for 48 hours. Upon completion of the reaction, the methanol was removed by rotary evaporation. The remaining aqueous phase was acidified with 4 M hydrochloric acid to pH < 3. The acidified aqueous phase was extracted three times with ethyl acetate and the organic phases were combined. The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated to obtain the crude product. The crude product was purified by rapid column chromatography on silica gel with heptane/ethyl acetate gradient elution. The final product yield was 31%. The structure of the product was confirmed by 1H NMR (D6-DMSO): δ 3.33 (t, 2H); 4.10 (t, 2H); 6.51 (d, 1H); 7.16 (d, 1H); 7.30 (dd, 1H).

References

[1] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 24, p. 8219 - 8248
[2] Patent: WO2005/39572, 2005, A1. Location in patent: Page/Page column 33
[3] Patent: US2016/355483, 2016, A1. Location in patent: Paragraph 0382-0383

3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid Suppliers

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