5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine
- Product Name
- 5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine
- CAS No.
- 228710-82-5
- Chemical Name
- 5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine
- Synonyms
- 5-Bromo-2-(2,5-dimethylpyrrol-1-yl)pyridine;5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine;Pyridine, 5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)-
- CBNumber
- CB11559883
- Molecular Formula
- C11H11BrN2
- Formula Weight
- 251.12
- MOL File
- 228710-82-5.mol
5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine Property
- Density
- 1.40
- storage temp.
- Sealed in dry,Room Temperature
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- B678073
- Product name
- 5-Bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB144196
- Product name
- 5-Bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine
- Packaging
- 250mg
- Price
- $62.5
- Updated
- 2021/12/16
- Product number
- FB144196
- Product name
- 5-Bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FB144196
- Product name
- 5-Bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine
- Packaging
- 1g
- Price
- $189
- Updated
- 2021/12/16
- Product number
- CS-0112821
- Product name
- 5-Bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine
- Packaging
- 1g
- Price
- $229
- Updated
- 2021/12/16
5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine Chemical Properties,Usage,Production
Uses
5-Bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine is useful reactant and reagent for the synthesis of different organic compounds.
Synthesis
1072-97-5
110-13-4
228710-82-5
2-Amino-5-bromopyridine (13.8 g, 0.08 mol) and 2,5-hexanedione (14.1 mL, 0.12 mol) were dissolved in toluene (180 mL) and p-toluenesulfonic acid (100 mg) was added as catalyst. The reaction mixture was placed under reflux for 14 hours under a Dean-Stark apparatus. After completion of the reaction, it was cooled to room temperature and the brown reaction solution was poured into water (200 mL) and extracted with toluene (2 x 200 mL). The organic phases were combined, washed with brine (50 mL), dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography with the eluent of ethyl acetate:pentane (1:3) to afford 5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine as a brown oil (18.4 g, 0.073 mol, 92% yield). The structure of the product was confirmed by 1H NMR (CDCl3, 400 MHz): δ 2.18 (s, 6H), 5.90 (s, 2H), 7.11 (d, 1H), 7.92 (d, 1H), 8.62 (s, 1H). Low resolution mass spectrometry (LRMS) shows m/z 253 ([M-H]+, Br isotope included).
References
[1] Organic Process Research and Development, 2004, vol. 8, # 4, p. 587 - 592
[2] Patent: WO2004/52372, 2004, A1. Location in patent: Page 85-86
[3] Patent: WO2008/87512, 2008, A1. Location in patent: Page/Page column 51-52
[4] Asian Journal of Chemistry, 2016, vol. 28, # 6, p. 1403 - 1404
[5] Patent: WO2006/82511, 2006, A1. Location in patent: Page/Page column 6; 36-37
5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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