sodium 3-[1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)-3-tert-butylsulfanyl-indol-2-yl]-2,2-dimethyl-propanoate
- Product Name
- sodium 3-[1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)-3-tert-butylsulfanyl-indol-2-yl]-2,2-dimethyl-propanoate
- CAS No.
- 147030-01-1
- Chemical Name
- sodium 3-[1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)-3-tert-butylsulfanyl-indol-2-yl]-2,2-dimethyl-propanoate
- Synonyms
- MK 591;MK-591 sodium;Quiflapon SodiuM;QUIFLAPON SODIUM (MK591);5-Lipoxygenase Inhibitor, MK591;QUIFLAPON SODIUM; MK-591; MK 591;sodium 3-[1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)-3-tert-butylsulfanyl-indol-2-yl]-2,2-dimethyl-propanoate;1-[(4-Chlorophenyl)Methyl]-3-[(1,1-diMethylethyl)thio]-α,α-diMethyl-5-(2-quinolinylMethoxy)-1H-Indole-2-propanoic Acid SodiuM Salt
- CBNumber
- CB11568667
- Molecular Formula
- C34H34ClN2NaO3S
- Formula Weight
- 0
- MOL File
- 147030-01-1.mol
sodium 3-[1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)-3-tert-butylsulfanyl-indol-2-yl]-2,2-dimethyl-propanoate Property
- storage temp.
- -20°C
- solubility
- DMSO : 50 mg/mL (82.08 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- form
- Powder
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 5.32606
- Product name
- 5-Lipoxygenase Inhibitor, MK591 - CAS 147030-01-1 - Calbiochem
- Purity
- MK591; MK0591; 5-LOX inhibitor, 5- Lipoxygenase inhibitor, FLAP
- Packaging
- 5MG
- Price
- $189
- Updated
- 2025/07/31
- Product number
- Q535400
- Product name
- QuiflaponSodium
- Packaging
- 10mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- Q535400
- Product name
- QuiflaponSodium
- Packaging
- 100mg
- Price
- $1470
- Updated
- 2021/12/16
- Product number
- API0009226
- Product name
- MK-591
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $2194.5
- Updated
- 2021/12/16
- Product number
- CS-0936
- Product name
- Quiflapon(sodium)
- Purity
- 98.65%
- Packaging
- 100mg
- Price
- $1320
- Updated
- 2021/12/16
sodium 3-[1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)-3-tert-butylsulfanyl-indol-2-yl]-2,2-dimethyl-propanoate Chemical Properties,Usage,Production
Uses
Quiflapon is a synthetic compound which specifically inhibits the activity of 5-Lox and is currently under development for the treatment of asthma. Also, Quiflapon, a leukotriene biosynthesis inhibitor, induces apoptosis in prostate cancer cells.
Biological Activity
Cell permeable: yes', 'Primary Target
FLAP
in vivo
Hyperoxia groups of mice treated with Quiflapon sodium (MK591) (20, 40 mg/kg) show alveolarization that resembles that of room air controls while untreated hyperoxia groups show definite evidence of aberrant alveolarization but no inflammation[3]. Comparison of the Aβ-immunopositive areas between the placebo and Quiflapon sodium (MK591) (320 mg/kg)-treated group reveals a statistically significant reduction of the amyloid burden in the treated mice. Quiflapon sodium also has a significant reduction in brain levels of IL-1β. Mice treated with Quiflapon sodium show a statistically significant decrease in the steady-state levels of total CREB and its phosphorylated form at Ser133[4].
target
FLAP
sodium 3-[1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)-3-tert-butylsulfanyl-indol-2-yl]-2,2-dimethyl-propanoate Preparation Products And Raw materials
Raw materials
Preparation Products
sodium 3-[1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)-3-tert-butylsulfanyl-indol-2-yl]-2,2-dimethyl-propanoate Suppliers
- Tel
- --
- Fax
- --
- contact@achemica.com
- Country
- Switzerland
- ProdList
- 6155
- Advantage
- 50
View Lastest Price from sodium 3-[1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)-3-tert-butylsulfanyl-indol-2-yl]-2,2-dimethyl-propanoate manufacturers
- Product
- sodium 3-[1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)-3-tert-butylsulfanyl-indol-2-yl]-2,2-dimethyl-propanoate 147030-01-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-18