4-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 95%
- Product Name
- 4-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 95%
- CAS No.
- 938043-30-2
- Chemical Name
- 4-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 95%
- Synonyms
- 4-(4-Methylpiperazino)methylphenylboronic acid, pinacol ester;4-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ...;4-(4-Methyl-1-piperazinemethyl)phenylboronic acid pinacol ester;4-[(4-Methylpiperazin-1-yl)methyl]benzeneboronicacidpinacolester;4-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester;4-[(4-Methyl-1-piperazinyl)methyl]phenylboronic Acid Pinacol Ester;4-((4-Methylpiperazin-1-yl)methyl)-phenylboronic acid pinacol ester;4-(4-METHYL-1-PIPERAZINYLMETHYL)BENZENEBORONIC ACID PINACOL ESTER,95%;4-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 95%;4-[(4-Methylpiperazin-1-yl)methyl]benzeneboronic acid pinacol ester 95%
- CBNumber
- CB11569846
- Molecular Formula
- C18H29BN2O2
- Formula Weight
- 316.25
- MOL File
- 938043-30-2.mol
4-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 95% Property
- Melting point:
- 61-65°C
- Boiling point:
- 412.7±35.0 °C(Predicted)
- Density
- 1.06±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- pka
- 7.59±0.10(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 938043-30-2
Safety
- WGK Germany
- 3
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 797197
- Product name
- 1-methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]piperazine
- Packaging
- 500mg
- Price
- $106
- Updated
- 2023/01/07
- Product number
- M725695
- Product name
- 4-((4-Methylpiperazin-1-yl)methyl)phenylboronicAcidPinacolEster
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M725695
- Product name
- 4-((4-Methylpiperazin-1-yl)methyl)phenylboronicAcidPinacolEster
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- M725695
- Product name
- 4-((4-Methylpiperazin-1-yl)methyl)phenylboronicAcidPinacolEster
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 102105
- Product name
- 4-((4-Methylpiperazin-1-yl)methyl)-phenylboronic acid pinacol ester
- Purity
- >95%
- Packaging
- 1g
- Price
- $58
- Updated
- 2021/12/16
4-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 95% Chemical Properties,Usage,Production
Synthesis
368879-17-8
73183-34-3
938043-30-2
To a stirred solution of 1-[(4-bromophenyl)methyl]-4-methylpiperazine (35.0 g, 130 mmol) in 1,4-dioxane (500 mL) was added potassium acetate (38.3 g, 390 mmol) and pinacol ester of bisboronic acid (33.0 g, 130 mmol) at room temperature. The mixture was evacuated and replaced with nitrogen (repeated three times). After addition of Pd(dppf)Cl2 (3.0 g, 1.3 mmol), the reaction mixture was stirred at 110 °C for 12 h under nitrogen atmosphere. After completion of the reaction, the mixture was cooled to room temperature and filtered to remove solids. The filtrate was concentrated and the residue was diluted with ethyl acetate and water. The organic layer was separated, dried with anhydrous Na2SO4 and concentrated. Purification of the residue by rapid column chromatography on silica gel (eluent ratio: DCM/MeOH = 50:1 to 10:1) afforded 4-(4-methyl-1-piperazinylmethyl)phenylboronic acid pinacol ester (37.0 g, 90% yield) as a brown solid.
References
[1] Patent: WO2015/32945, 2015, A1. Location in patent: Page/Page column 26; 27
[2] Patent: US2018/44328, 2018, A1. Location in patent: Paragraph 0162; 0174; 0175
[3] Patent: WO2012/119941, 2012, A1. Location in patent: Page/Page column 116
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 2, p. 196 - 218
[5] European Journal of Medicinal Chemistry, 2016, vol. 122, p. 684 - 701
4-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 95% Preparation Products And Raw materials
Raw materials
Preparation Products
4-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 95% Suppliers
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View Lastest Price from 4-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 95% manufacturers
- Product
- 4-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 95% 938043-30-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 4-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 95% 938043-30-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 4-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 95% 938043-30-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1lg; 2kg; 5kg; 10kg; 100kg
- Release date
- 2019-08-31