CLOXAZOLAM Property

Melting point:

202-204° (dec)

Boiling point:

172°C (rough estimate)

Density 

1.4125 (rough estimate)

refractive index 

1.6100 (estimate)

pka

12.70±0.40(Predicted)

CAS DataBase Reference

24166-13-0

Safety

RIDADR 

3249

HazardClass 

6.1(b)

PackingGroup 

III

Toxicity

LD50 in mice (g/kg): 3.3 orally; >2.0 i.p. (Kamioka)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H336May cause drowsiness or dizziness

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

CLOXAZOLAM Chemical Properties,Usage,Production

Originator

Sepazon,Sankyo,Japan,1974

Uses

CLOXAZOLAM is a benzodiazepine derivative with anxiolytic, hypnotic and antihypertensive properties used as an anti-anxiety drug. It is metabolized into the active metabolite Delorezepam (D230675). Controlled Subs tance.

Definition

ChEBI: Cloxazolam is an oxazolobenzodiazepine and a hemiaminal ether.

Manufacturing Process

As described in US Patent 3,772,371: To a solution of 5.8 g of 5-chloro-2- bromoacetylamino-o-chlorobenzophenone in 120 ml of ethanol were added 0.95 g of ethanolamine and 1.3 g of sodium acetate. The resulting mixture was heated under reflux for 16 hours.
After completion of the reaction, the solvent was distilled off and the residue was extracted with dichloromethane. The extract was washed with water, dried over anhydrous sodium sulfate and the solvent was distilled off to give 3.25 g of the desired product melting at 202° to 204°C with decomposition.

Therapeutic Function

Tranquilizer