2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE

Product Name: 2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE
CAS No.: 51-02-5
Chemical Name: 2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE
Synonyms: ici38174;PronethalolHCl;alderlinhydrochloride;(+/-)-Pronethalol HCl;nethalidehydrochloride;PRONETHALOL HYDROCHLORIDE;naphthylisoproterenolhydrochloride;2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE;1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol hydrochloride;alpha-((isopropylamino)methyl)-naphthalenemethanohydrochloride
CBNumber: CB1165100
Molecular Formula: C15H20ClNO
Formula Weight: 265.78
MOL File: 51-02-5.mol

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2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE Property

Melting point:: 184°
storage temp.: Store at RT
form: Powder
Water Solubility: Soluble to 100 mM in water
IARC: 3 (Vol. 13, Sup 7) 1987
EPA Substance Registry System: Pronetalol hydrochloride (51-02-5)

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Safety

Toxicity: LD50 in mice (mg/kg): 512 orally, 46 i.v. (Black)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris

Product number: 0829
Product name: Pronethalolhydrochloride
Purity: ≥99%(HPLC)
Packaging: 100
Price: $80
Updated: 2021/12/16

ApexBio Technology

Product number: B5023
Product name: Pronethalolhydrochloride
Packaging: 10mg
Price: $236
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0304346
Product name: 2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $505.55
Updated: 2021/12/16

AHH

Product number: MT-16093
Product name: 2-Isopropylamino-1-(2-naphthyl)ethanolhydrochloride
Purity: 98%
Packaging: 1g
Price: $342
Updated: 2021/12/16

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2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs)[1][2].

Definition

ChEBI: Pronetalol hydrochloride is an organic molecular entity.

Biological Activity

β -adrenergic antagonist, clinically effective in the treatment of angina pectoris and some arrhythmias.

in vivo

Pronethalol (0.15 mg/g; daily; for 14 days) stabilizes endothelial differentiation, lumen formation and improves cerebral arteriovenous malformation (AVMs) in Mgp^–/– mice^[2].

IC 50

β adrenergic receptor

References

[1] Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71(4):503-8. DOI:10.1016/0002-8703(66)90217-1
[2] Jiayi Yao, et al. Elevated endothelial Sox2 causes lumen disruption and cerebral arteriovenous malformations. J Clin Invest. 2019 Jun 24;129(8):3121-3133. DOI:10.1172/JCI125965
[3] Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71(4):503-508.

2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE Suppliers

China 9 Germany 1 United Kingdom 4 United States 7 USA 1 Global 22

3B Pharmachem (Wuhan) International Co.,Ltd.

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TargetMol Chemicals Inc.

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Shanghai Maclean Biochemical Technology Co., LTD

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Biosynth Biological Technology (Suzhou) Co Ltd

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51-02-5, 2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDERelated Search:

2-Naphthalenemethanol Pronetalol 2-(2-NAPHTHYL)ETHYLAMINE HYDROCHLORIDE 1-(2-NAPHTHYL)ETHANOL 2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE 2-AMINO-1-(2-NAPHTHYL)-1-ETHANOL

PRONETHALOL HYDROCHLORIDE

2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE

PronethalolHCl

1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol hydrochloride

alderlinhydrochloride

alpha-(((1-methylethyl)amino)methyl)-2-naphthalenemethanol,hydrochloride

alpha-((isopropylamino)methyl)-2-naphthalenemethanolhydrochloride

alpha-((isopropylamino)methyl)-naphthalenemethanohydrochloride

ici38174

naphthylisoproterenolhydrochloride

nethalidehydrochloride

(+/-)-Pronethalol HCl

51-02-5

1951-2-5

C15H19NOHCl