ChemicalBook > CAS DataBase List > 5(S), 15(S)-DIHETE

5(S), 15(S)-DIHETE

Product Name: 5(S), 15(S)-DIHETE
CAS No.: 82200-87-1
Chemical Name: 5(S), 15(S)-DIHETE
Synonyms: 5,15-DiHETE;5(S), 15(S)-DIHETE;5(S),15(S)-DiHETE(solution in ethanol);5(S),15(S)-DiHETE Lipid Maps MS Standard;5,15-dihydroxy-6,8,11,13-eicosatetraenoicacid;(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-*eicosatetraen;(5S,15S)-DIHYDROXY-(6E,8Z,11Z,13E)-EICOS ATETRAENOI;5S,15S-DIHYDROXY-6E,8Z,11Z,13E-EICOSATETRAENOIC ACID;5(S),15(S)-DIHYDROXYEICOSA-6E,8Z,11Z,13E-TETRAENOIC ACID;5(S),15(S)-dihydroxy-6(E),8(Z),10(Z),13(E)-eicosatetraenoic aci
CBNumber: CB1165261
Molecular Formula: C20H32O4
Formula Weight: 336.47
MOL File: 82200-87-1.mol

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5(S), 15(S)-DIHETE Property

storage temp.: -20°C
solubility: DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml
form: Colorless liquid.
color: Colorless to light yellow

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Safety

Hazard Codes: F,Xi
Risk Statements: 11-36/37/38
Safety Statements: 16-26-36

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 35280
Product name: 5(S),15(S)-DiHETE
Purity: ≥98%
Packaging: 25μg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 35280
Product name: 5(S),15(S)-DiHETE
Purity: ≥98%
Packaging: 50μg
Price: $156
Updated: 2024/03/01

Cayman Chemical

Product number: 35280
Product name: 5(S),15(S)-DiHETE
Purity: ≥98%
Packaging: 100μg
Price: $291
Updated: 2024/03/01

TRC

Product number: D446403
Product name: 5(S),15(S)-DiHETE
Packaging: 100μg
Price: $210
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0005951
Product name: 5S,15S-DIHYDROXY-6E,8Z,10Z,13E-EICOSATETRAENOIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $498.86
Updated: 2021/12/16

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5(S), 15(S)-DIHETE Chemical Properties,Usage,Production

Description

5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE. It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB₄. 5(S),15(S)-DiHETE is chemotactic for eosinophils with an ED₅₀ value of 0.3 μM.

Uses

5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE. It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB4. 5(S),15(S)-DiHETE is chemotactic for eosinophils with an ED50 value of 0.3 μM.

Uses

5(S),15(S)-DiHETE is an enhancer of neutrophil degranulation and potent chemotaxin.

Definition

ChEBI: 5(S),15(S)-DiHETE is a DiHETE that is (6E,8Z,11Z,13E)-icosatetraenoic acid in which the two hydroxy substituents are placed at the 5S- and 15S-positions. It has a role as a rat metabolite and a human xenobiotic metabolite. It is a conjugate acid of a 5(S),15(S)-DiHETE(1-).

References

[1] GREEN F A. Transformations of 5-HETE by activated keratinocyte 15-lipoxygenase and the activation mechanism[J]. Lipids, 1990, 25 10: 618-623. DOI: 10.1007/bf02536012
[2] JOSEPH T. O’FLAHERTY Michael J T. Effect of 15-lipoxygenase-derived arachidonate metabolites on human neutrophil degranulation[J]. Prostaglandins, leukotrienes, and medicine, 1985, 17 2: Pages 199-212. DOI: 10.1016/0262-1746(85)90107-6
[3] E. MORITA E C J Schr?der. Identification of a novel and highly potent eosinophil chemotactic lipid in human eosinophils treated with arachidonic acid.[J]. Journal of immunology, 1990, 144 5 1: 1893-1900. DOI: 10.4049/jimmunol.144.5.1893

5(S), 15(S)-DIHETE Preparation Products And Raw materials

Raw materials

Preparation Products

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5(S), 15(S)-DIHETE Suppliers

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82200-87-1, 5(S), 15(S)-DIHETERelated Search:

5(S),15(S)-DIHETE [1-14C] 8(S),15(S)-DIHETE [1-14C] (8S,15S)-DIHETE 8(S),15(S)-DIHETE 8(R),15(S)-DIHETE 5(S), 15(S)-DIHETE

5(S), 15(S)-DIHETE

5S,15S-DIHYDROXY-6E,8Z,11Z,13E-EICOSATETRAENOIC ACID

5(S),15(S)-DIHYDROXYEICOSA-6E,8Z,11Z,13E-TETRAENOIC ACID

5,15-dihydroxy-6,8,11,13-eicosatetraenoicacid

(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-*eicosatetraen

(5S,15S)-DIHYDROXY-(6E,8Z,11Z,13E)-EICOS ATETRAENOI

5(S),15(S)-DiHETE Lipid Maps MS Standard

5,15-DiHETE

6,8,11,13-Eicosatetraenoic acid, 5,15-dihydroxy-, (5S,6E,8Z,11Z,13E,15S)-

5(S),15(S)-Dihydroxy-6(E),8(Z),10(Z),13(E)-Eicosatetraenoic acid

5(S),15(S)-dihydroxy-6(E),8(Z),10(Z),13(E)-eicosatetraenoic aci

5(S),15(S)-DiHETE(solution in ethanol)

82200-87-1