METHYL N-BENZYL-3-PYRROLIDINECARBOXYLATE

Product Name: METHYL N-BENZYL-3-PYRROLIDINECARBOXYLATE
CAS No.: 17012-21-4
Chemical Name: METHYL N-BENZYL-3-PYRROLIDINECARBOXYLATE
Synonyms: Methyl 1-benzyllpyrrolidi...;Methyl 1-benzyl-3-pyrrolidinecarboxylate;METHYL N-BENZYL-3-PYRROLIDINECARBOXYLATE;METHYL 1-BENZYLPYRROLIDINE-3-CARBOXYLATE;Methyl 1-benzyllpyrrolidine-3-carboxylate;MethylN-benzylpyrrolidine-3-carboxylate,97%;Methyl 1-benzylpyrrolidine-3-carboxylate 97%;Methyl N-benzylpyrrolidine-3-carboxylate, 97%;Methyl 1-(phenylmethyl)-3-pyrrolidinecarboxylate;N-benzyl-pyrrolidine-3-carboxylicacidmethylester
CBNumber: CB1183304
Molecular Formula: C13H17NO2
Formula Weight: 219.28
MOL File: 17012-21-4.mol

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METHYL N-BENZYL-3-PYRROLIDINECARBOXYLATE Property

Boiling point:: 98℃/0.2mm
Density: 1.08
refractive index: 1.5211
storage temp.: 2-8°C
form: clear liquid
pka: 8.34±0.40(Predicted)
color: Colorless to Light orange to Yellow
Water Solubility: Sparingly soluble in water.(0.26 g/L) (25°C),
InChI: InChI=1S/C13H17NO2/c1-16-13(15)12-7-8-14(10-12)9-11-5-3-2-4-6-11/h2-6,12H,7-10H2,1H3
InChIKey: GDWFCUOFVSNTTG-UHFFFAOYSA-N
SMILES: N1(CC2=CC=CC=C2)CCC(C(OC)=O)C1
CAS DataBase Reference: 17012-21-4

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2866
Product name: Methyl 1-Benzylpyrrolidine-3-carboxylate
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $70
Updated: 2025/07/31

TCI Chemical

Product number: M2866
Product name: Methyl 1-Benzylpyrrolidine-3-carboxylate
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $207
Updated: 2025/07/31

TRC

Product number: B486058
Product name: Methyl 1-Benzylpyrrolidine-3-carboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 069019
Product name: Methyl 1-benzyllpyrrolidine-3-carboxylate
Purity: >95%
Packaging: 1g
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR52084
Product name: Methyl 1-Benzylpyrrolidine-3-carboxylate
Purity: 98%
Packaging: 1g
Price: $66
Updated: 2021/12/16

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METHYL N-BENZYL-3-PYRROLIDINECARBOXYLATE Chemical Properties,Usage,Production

Uses

It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.

Synthesis Reference(s)

The Journal of Organic Chemistry, 33, p. 3637, 1968 DOI: 10.1021/jo01273a063

Synthesis

93102-05-7

292638-85-8

17012-21-4

A trifluoroacetic acid solution of 44.0 g (0.4 mol) at a mass concentration of 10% was prepared by adding 1530.0 g (6.5 mol) of N-(methoxymethyl)-N-(trimethylsilylmethyl)benzylamine, 31.80 g (3.7 mol) of methyl acrylate, and 38 mL of dichloromethane to a 250 mL multi-neck reaction flask. The trifluoroacetic acid solution was added slowly dropwise at 0 °C, and after completion of the dropwise addition, the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was concentrated under reduced pressure and the residue was washed sequentially with saturated sodium bicarbonate solution and saturated sodium chloride solution. The organic phases were combined, dried with anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure to give 1420.0 g of 1-benzylpyrrolidine-3-carboxylic acid methyl ester crude product in 100% yield.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 19, p. 4861 - 4866
[2] Organic Process Research and Development, 2009, vol. 13, # 2, p. 292 - 296
[3] Synthesis, 2006, # 16, p. 2646 - 2648
[4] Synlett, 2015, vol. 26, # 13, p. 1815 - 1818
[5] Chemical & Pharmaceutical Bulletin, 1985, vol. 33, # 7, p. 2762 - 2766

METHYL N-BENZYL-3-PYRROLIDINECARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL N-BENZYL-3-PYRROLIDINECARBOXYLATE Suppliers

Americas 1 Canada 1 China 128 Europe 1 Germany 2 India 4 Japan 1 United Kingdom 2 United States 17 Global 157

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View Lastest Price from METHYL N-BENZYL-3-PYRROLIDINECARBOXYLATE manufacturers

Career Henan Chemical Co

Product: METHYL N-BENZYL-3-PYRROLIDINECARBOXYLATE 17012-21-4
Price: US $8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-25

17012-21-4, METHYL N-BENZYL-3-PYRROLIDINECARBOXYLATERelated Search:

ETHYL N-PHENYLFORMIMIDATE Ethyl 1-benzylpyrrolidine-3-carboxylate METHYL N-BENZYL-3-PYRROLIDINECARBOXYLATE Methyl formate DIETHYL CIS-1-BENZYL-3,4-PYRROLIDINEDICARBOXYLATE Methyl 1-Benzyl-5-oxopyrrolidine-3-carboxylate 1-BENZYLPYRROLIDINE-3,4-DICARBOXYLIC ACID MONOMETHYL ESTER 2-BENZYL-HEXAHYDRO-PYRANO[3,4-C]PYRROL-4-ONE Ethyl 1-(4-methoxybenzoyl)-2-oxo-4-phenyl-3-pyrrolidinecarboxylate 7-BENZYL-2-OXA-7-AZA-SPIRO[4.4]NONAN-1-ONE 5-BENZYL-TETRAHYDRO-FURO[3,4-C]PYRROLE-1,3-DIONE 2-BENZYL-5-METHYL-OCTAHYDRO-PYRROLO[3,4-C]PYRIDINE-7A-CARBOXYLIC ACID ETHYL ESTER 5-BENZYL-3A,6A-DIMETHYL-TETRAHYDRO-FURO[3,4-C]PYRROLE-1,3-DIONE 5-BENZYL-3A-METHYL-TETRAHYDRO-FURO[3,4-C]PYRROLE-1,3-DIONE TRITYL-L-TRANSPRO(4-COOME)-OME 5-BENZYL-6A-METHYL-HEXAHYDRO-FURO[3,4-C]PYRROL-1-ONE 5-BENZYL-3A-METHOXY-HEXAHYDRO-FURO[3,4-C]PYRROL-1-ONE 1-BENZYL-4-METHOXY-PYRROLIDINE-3-CARBOXYLIC ACID METHYL ESTER

1-BENZYL-PYRROLIDINE-3-CARBOXYLIC ACID METHYL ESTER

METHYL 1-BENZYLPYRROLIDINE-3-CARBOXYLATE

METHYL N-BENZYL-3-PYRROLIDINECARBOXYLATE

Methyl 1-benzyllpyrrolidine-3-carboxylate

3-Pyrrolidinecarboxylic acid, 1-(phenylMethyl)-, Methyl ester

1-Benzyl-3-pyrrolidinecarboxylic acid methyl ester

Methyl 1-benzyl-3-pyrrolidinecarboxylate

Methyl 1-benzyllpyrrolidi...

MethylN-benzylpyrrolidine-3-carboxylate,97%

Methyl N-benzylpyrrolidine-3-carboxylate, 97%

1-Benzyl-3-(methoxycarbonyl)pyrrolidine, Methyl 1-(phenylmethyl)pyrrolidine-3-carboxylate

Methyl 1-benzylpyrrolidine-3-carboxylate 97%

Methyl 1-(phenylmethyl)-3-pyrrolidinecarboxylate

N-benzyl-pyrrolidine-3-carboxylicacidmethylester

17012-21-4

pharmacetical