5,7-dichloro-1,6-naphthyridine
Uses- Product Name
- 5,7-dichloro-1,6-naphthyridine
- CAS No.
- 337958-60-8
- Chemical Name
- 5,7-dichloro-1,6-naphthyridine
- Synonyms
- SKL321;5,7-Dichloro-1,6phthyridine;5,7-dichloro-1,6-naphthyridine;1,6-Naphthyridine,5,7-dichloro-
- CBNumber
- CB11856142
- Molecular Formula
- C8H4Cl2N2
- Formula Weight
- 199.04
- MOL File
- 337958-60-8.mol
5,7-dichloro-1,6-naphthyridine Property
- Boiling point:
- 344.5±37.0 °C(Predicted)
- Density
- 1.486±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Crystalline Powder
- pka
- 0.82±0.30(Predicted)
- color
- White to yellow
- InChI
- InChI=1S/C8H4Cl2N2/c9-7-4-6-5(8(10)12-7)2-1-3-11-6/h1-4H
- InChIKey
- HNRPBMNTCYRAJD-UHFFFAOYSA-N
- SMILES
- N1C2C(=C(Cl)N=C(Cl)C=2)C=CC=1
- CAS DataBase Reference
- 337958-60-8
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D434983
- Product name
- 5,7-dichloro-1,6-naphthyridine
- Packaging
- 500mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- OR951540
- Product name
- 5,7-Dichloro-1,6-naphthyridine
- Purity
- 95%
- Packaging
- 5g
- Price
- $340
- Updated
- 2021/12/16
- Product number
- OR951540
- Product name
- 5,7-Dichloro-1,6-naphthyridine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $66
- Updated
- 2021/12/16
- Product number
- FD144198
- Product name
- 5,7-Dichloro-1,6-naphthyridine
- Packaging
- 2g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- V2400
- Product name
- 5,7-Dichloro-1,6-naphthyridine
- Packaging
- 1g
- Price
- $439
- Updated
- 2021/12/16
5,7-dichloro-1,6-naphthyridine Chemical Properties,Usage,Production
Uses
5,7-Dichloro-1,6-Naphthidine is used in organic synthesis and can be applied in laboratory research and development processes as well as in chemical and pharmaceutical synthesis.
Synthesis
927-63-9
1345456-45-2
337958-60-8
The general procedure for the synthesis of 5,7-dichloro-1,6-naphthyridines from 3-dimethylaminoacrolein and N-(2,6-dichloropyridin-4-yl)pivalamide is as follows: Intermediate 7: Synthesis of 5,7-dichloro-1,6-diazanaphthalene 1. dissolve N-(2,6-dichloro-4-pyridinyl)-2,2-dimethylpropanamide (1 g, 4.05 mmol) in tetrahydrofuran (THF, 10 ml) and cool to below -60 °C under nitrogen protection. 2. Slowly add n-butyllithium (4.05 ml, 10.12 mmol, 2.5 M hexane solution), keep the temperature below -60°C, and control the addition time within 30 minutes. After addition, continue stirring below -70°C for 1 hour. 3. THF (2 ml) solution of (2E)-3-(dimethylamino)-2-propenal (0.607 ml, 6.07 mmol) was added dropwise over 30 min, keeping the reaction temperature below -60 °C. After dropwise addition, the reaction mixture was stirred below -70°C for 20 min and then slowly warmed up to room temperature. 4. The progress of the reaction was monitored by LCMS and after confirming complete consumption of the feedstock, the reaction was quenched with 5 M hydrochloric acid (5 ml) and the mixture was refluxed overnight. 5. After LCMS showed good conversion of the product, the reaction mixture was cooled to room temperature, alkalized with solid potassium carbonate (K2CO3) and subsequently extracted with ethyl acetate (EtOAc, 4 x 25 ml). 6. The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated to give a brown solid crude product. 7. The crude product was purified by column chromatography using a 40+M silica gel column, eluting first with 12% ether in cyclohexane solution for 2 column volumes (CV), then with a gradient of 12%-63% ether in cyclohexane solution for 10 CV, and finally keeping the elution in 63% ether in cyclohexane solution until completion. 8. The fractions containing the target product were collected, combined and the solvents evaporated to afford 5,7-dichloro-1,6-naphthyridine as a yellow solid (0.42 g). LCMS (Method B): retention time (Rt) = 0.89 min, molecular ion peak (MH+) = 199/201.
References
[1] Patent: WO2011/134971, 2011, A1. Location in patent: Page/Page column 12; 13; 53; 54
[2] Patent: US2013/40984, 2013, A1. Location in patent: Paragraph 0384-0386
5,7-dichloro-1,6-naphthyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5,7-dichloro-1,6-naphthyridine manufacturers
- Product
- 5,7-Dichloro-1,6-naphthyridine 337958-60-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 20000
- Release date
- 2020-12-17
- Product
- 5,7-dichloro-1,6-naphthyridine 337958-60-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 5,7-dichloro-1,6-naphthyridine 337958-60-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-22