ChemicalBook > CAS DataBase List > dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate

dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate

Product Name
dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate
CAS No.
2166-14-5
Chemical Name
dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate
Synonyms
Nsc174664;TETRAZINE DERIVATIVE 2166-14-5;dimethyl 1,2,4,5-tetrazine-3,6-dicarboxyl;3,6-Bis(methoxycarbonyl)-1,2,4,5-tetrazine;3,6-dicarboxylic acid methyl ester tetrazine;dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate;3,6-dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate;1,2,4,5-Tetrazine-3,6-dicarboxylic acid, diMethyl ester;1,2,4,5-Tetrazine-3,6-dicarboxylic acid, 3,6-dimethyl ester
CBNumber
CB11871486
Molecular Formula
C6H6N4O4
Formula Weight
198.14
MOL File
2166-14-5.mol
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dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate Property

Melting point:
176 °C(Solv: acetic acid (64-19-7))
Boiling point:
358.9±25.0 °C(Predicted)
Density 
1.434±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
sol dioxane, CH2Cl2, THF, C6H6; insol H2O.
form 
crystals
pka
-3.68±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
ALD00098
Product name
3,6-Bis(methoxycarbonyl)-1,2,4,5-tetrazine
Packaging
1G
Price
$584.66
Updated
2025/07/31
TRC
Product number
D458215
Product name
3,6-dimethyl1,2,4,5-tetrazine-3,6-dicarboxylate
Packaging
5mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
7139BA
Product name
Dimethyl1,2,4,5-tetrazine-3,6-dicarboxylate
Packaging
1g
Price
$268
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM1027879
Product name
1,2,4,5-TETRAZINE-3,6-DICARBOXYLIC ACID DIMETHYL ESTER
Purity
95.00%
Packaging
5MG
Price
$497.65
Updated
2021/12/16
Crysdot
Product number
CD11165091
Product name
Dimethyl1,2,4,5-tetrazine-3,6-dicarboxylate
Purity
95+%
Packaging
5g
Price
$446
Updated
2021/12/16
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dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate Chemical Properties,Usage,Production

Uses

3,6-Dimethyl 1,2,4,5-Tetrazine-3,6-dicarboxylate (CAS# 2166-14-5) can be used in the synthesis of N-?substituted dibenzoazepine-?pyridazine derivatives via Diels-Alder reaction of dibenzoazepines with tetrazines for their use as potential neurologically active drugs.

Application

Dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate is a reactive heteroaromatic azadiene with inverse electron demand that undergoes Diels-Alder reactions with a variety of dienophiles and isodieniphiles; it is used to prepare substituted 1,2-diazines, 1,2,4-triazines, pyrroles, pyridines, indolines, and related fused heterocycles.

storage

Dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate is a very reactive diene which  is unstable to acid, base, H2O, or protic solvents and should be stored moisture-free and refrigerated.

dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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2166-14-5, dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylateRelated Search:


  • dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate
  • Nsc174664
  • 1,2,4,5-Tetrazine-3,6-dicarboxylic acid, diMethyl ester
  • 3,6-dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate
  • 1,2,4,5-Tetrazine-3,6-dicarboxylic acid, 3,6-dimethyl ester
  • 3,6-Bis(methoxycarbonyl)-1,2,4,5-tetrazine
  • dimethyl 1,2,4,5-tetrazine-3,6-dicarboxyl
  • TETRAZINE DERIVATIVE 2166-14-5
  • 3,6-dicarboxylic acid methyl ester tetrazine
  • 2166-14-5
  • 2199-14-5