GRA Ex-25

Product Name: GRA Ex-25
CAS No.: 307983-31-9
Chemical Name: GRA Ex-25
Synonyms: GRA Ex-25;GRA Ex-25[GRA-Ex-25;GRA Ex-25 USP/EP/BP;GRA Ex-25, 10 mM in DMSO;GCGR,inhibit,GRA Ex 25,Inhibitor,GRA Ex-25,Glucagon Receptor,GRA Ex25;3-(4-((1-(trans-4-(tert-Butyl)cyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)propanoic acid;β-Alanine, N-[4-[[[trans-4-(1,1-dimethylethyl)cyclohexyl][[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]methyl]benzoyl]-;3-{[4-({1-[(1r,4r)-4-tert-butylcyclohexyl]{[4-(trifluoromethoxy)phenyl]carbamoyl}amino}methyl)phenyl]formamido}propanoic acid;B-Alanine, N-[4-[[[trans-4-(1,1-dimethylethyl)cyclohexyl][[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]methyl]benzoyl]-
CBNumber: CB11872296
Molecular Formula: C29H36F3N3O5
Formula Weight: 563.61
MOL File: 307983-31-9.mol

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GRA Ex-25 Property

Melting point:: 152-154 °C
Boiling point:: 726.3±60.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMF:25.0(Max Conc. mg/mL);44.36(Max Conc. mM)
DMSO:28.5(Max Conc. mg/mL);50.57(Max Conc. mM)
DMF:PBS (pH 7.2) (1:8):0.1(Max Conc. mg/mL);0.18(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);17.74(Max Conc. mM)
form: A crystalline solid
pka: 4.29±0.10(Predicted)
color: White to off-white
InChIKey: BZXMLCVDKDXRQY-AFARHQOCNA-N
SMILES: C(C)(C)([C@@H]1CC[C@H](CC1)N(CC1=CC=C(C=C1)C(=O)NCCC(=O)O)C(=O)NC1=CC=C(C=C1)OC(F)(F)F)C |&1:3,6,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29727
Product name: GRA Ex-25
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29727
Product name: GRA Ex-25
Packaging: 25mg
Price: $533
Updated: 2024/03/01

Cayman Chemical

Product number: 29727
Product name: GRA Ex-25
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 29727
Product name: GRA Ex-25
Packaging: 10mg
Price: $243
Updated: 2024/03/01

ChemScene

Product number: CS-6006
Product name: GRAEx-25
Purity: 99.70%
Packaging: 10mg
Price: $252
Updated: 2021/12/16

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GRA Ex-25 Chemical Properties,Usage,Production

Uses

GRA Ex-25 is an inhibitor of glucagon receptor, with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively.

in vivo

GRA Ex-25 (3 mg/kg, i.v.) significantly reduces blood glucose caused by exogenous administration of glucagon in rat model. GRA Ex-25 is able to inhibit the rise in blood glucose levels elicited by exogenous administered glucagon, most likely because of the direct inhibition of glucagon stimulated hepatic glucose output^[2].

References

[1] Kurukulasuriya R, et al. Biaryl amide glucagon receptor antagonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2047-50. DOI:10.1016/j.bmcl.2004.02.056
[2] Kurukulasuriya R, et al. Biaryl amide glucagon receptor antagonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2047-50. DOI:10.1021/jm058026u

GRA Ex-25 Preparation Products And Raw materials

Raw materials

Preparation Products

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GRA Ex-25 Suppliers

China 57 United States 6 USA 1 Global 64

MedChemexpress LLC

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Bide Pharmatech Ltd.

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Shanghai Lollane Biological Technology Co.,Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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Amadis Chemical Company Limited

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Musechem

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Shanghai BetterBioChem Co., Ltd.

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Twochem Co.Ltd.

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Angel Pharmatech, Ltd.

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307983-31-9, GRA Ex-25Related Search:

GRA Ex-25

B-Alanine, N-[4-[[[trans-4-(1,1-dimethylethyl)cyclohexyl][[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]methyl]benzoyl]-

β-Alanine, N-[4-[[[trans-4-(1,1-dimethylethyl)cyclohexyl][[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]methyl]benzoyl]-

GRA Ex-25 USP/EP/BP

GRA Ex-25[GRA-Ex-25

GCGR,inhibit,GRA Ex 25,Inhibitor,GRA Ex-25,Glucagon Receptor,GRA Ex25

3-(4-((1-(trans-4-(tert-Butyl)cyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)propanoic acid

3-{[4-({1-[(1r,4r)-4-tert-butylcyclohexyl]{[4-(trifluoromethoxy)phenyl]carbamoyl}amino}methyl)phenyl]formamido}propanoic acid

GRA Ex-25, 10 mM in DMSO

307983-31-9

C29H36F3N3O5