4-Thiazolecarboxaldehyde, 5-methyl-
- Product Name
- 4-Thiazolecarboxaldehyde, 5-methyl-
- CAS No.
- 261710-79-6
- Chemical Name
- 4-Thiazolecarboxaldehyde, 5-methyl-
- Synonyms
- 5-Methyl-4-thio-carbalddehyde;5-Methylthiazole-4-carbaldehyde;4-Thiazolecarboxaldehyde, 5-methyl-
- CBNumber
- CB11875505
- Molecular Formula
- C5H5NOS
- Formula Weight
- 127.16
- MOL File
- 261710-79-6.mol
4-Thiazolecarboxaldehyde, 5-methyl- Property
- Boiling point:
- 228.1±20.0 °C(Predicted)
- Density
- 1.270±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 0.99±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 2250AB
- Product name
- 5-Methylthiazole-4-carbaldehyde
- Packaging
- 250mg
- Price
- $651
- Updated
- 2021/12/16
- Product number
- CHM0390953
- Product name
- 5-METHYLTHIAZOLE-4-CARBALDEHYDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.56
- Updated
- 2021/12/16
- Product number
- CM189520
- Product name
- 5-methylthiazole-4-carbaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $511
- Updated
- 2021/12/16
- Product number
- CD11156936
- Product name
- 5-Methylthiazole-4-carbaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $541
- Updated
- 2021/12/16
- Product number
- CD11156936
- Product name
- 5-Methylthiazole-4-carbaldehyde
- Purity
- 97%
- Packaging
- 250mg
- Price
- $249
- Updated
- 2021/12/16
4-Thiazolecarboxaldehyde, 5-methyl- Chemical Properties,Usage,Production
Synthesis
61323-26-0
261710-79-6
Step 1: Synthesis of 5-methylthiazole-4-carboxaldehyde. Ethyl 5-methylthiazole-4-carboxylate (794 mg, 5.05 mmol) was dissolved in anhydrous THF (21.6 mL) under argon protection and cooled to -78 °C. A toluene solution of 1.0 M DIBAL-H (5.56 mL, 5.56 mmol) was added slowly and dropwise, keeping the reaction temperature at -78 °C. The reaction mixture was stirred at this temperature for 30 min. Subsequently, the reaction was quenched with deionized water (12.4 mL) and gradually warmed to room temperature. The reaction mixture was poured into 300 mL of saturated aqueous Rochelle's salt solution and diluted with EtOAc. After vigorous stirring of the mixture for 1 h, the organic and aqueous layers were separated. The aqueous layer was further extracted with EtOAc (3 times). All organic phases were combined, washed with saturated brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by ISCO column chromatography (eluent: 10% EtOAc in DCM solution) to give 642 mg (54% yield) of the title compound as a yellow oil.NMR (400 MHz, CDCl3) δ 10.22 (s, 1H), 8.62 (s, 1H), 2.83 (s, 3H).
References
[1] Journal of Medicinal Chemistry, 2001, vol. 44, # 14, p. 2319 - 2332
[2] Patent: WO2016/4136, 2016, A1. Location in patent: Paragraph 00670
4-Thiazolecarboxaldehyde, 5-methyl- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Thiazolecarboxaldehyde, 5-methyl- manufacturers
- Product
- 4-Thiazolecarboxaldehyde, 5-methyl- 261710-79-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-14