ChemicalBook > CAS DataBase List > 9ALPHA,11,15S-TRIHYDROXY-THROMBOX-13E-EN-1-OIC ACID

9ALPHA,11,15S-TRIHYDROXY-THROMBOX-13E-EN-1-OIC ACID

Product Name
9ALPHA,11,15S-TRIHYDROXY-THROMBOX-13E-EN-1-OIC ACID
CAS No.
64626-32-0
Chemical Name
9ALPHA,11,15S-TRIHYDROXY-THROMBOX-13E-EN-1-OIC ACID
Synonyms
TXB1;THROMBOXANE B1;JSDWWNLTJCCSAV-VZBVYBAISA-N;9ALPHA,11,15S-TRIHYDROXY-THROMBOX-13E-EN-1-OIC ACID;(13E,15S)-9α,11,15-Trihydroxythrombox-13-en-1-oic acid;2H-Pyran-3-heptanoic acid, tetrahydro-4,6-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]-, (2R,3S,4S)-
CBNumber
CB1187988
Molecular Formula
C20H36O6
Formula Weight
372.5
MOL File
64626-32-0.mol
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9ALPHA,11,15S-TRIHYDROXY-THROMBOX-13E-EN-1-OIC ACID Property

solubility 
DMF: 50 mg/ml; DMSO: 25 mg/ml; Ethanol: 50 mg/ml; Methyl Acetate: 10 mg/ml; PBS (pH 7.2): .15 mg/ml
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10006610
Product name
Thromboxane B1
Purity
>98%
Packaging
100 μg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
10006610
Product name
Thromboxane B1
Purity
>98%
Packaging
500 μg
Price
$89
Updated
2024/03/01
Cayman Chemical
Product number
10006610
Product name
Thromboxane B1
Purity
>98%
Packaging
1mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
10006610
Product name
Thromboxane B1
Purity
>98%
Packaging
5mg
Price
$535
Updated
2022/04/27
Cayman Chemical
Product number
10006610
Product name
Thromboxane B1
Purity
>98%
Packaging
10mg
Price
$951
Updated
2022/04/27
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9ALPHA,11,15S-TRIHYDROXY-THROMBOX-13E-EN-1-OIC ACID Chemical Properties,Usage,Production

Description

Dihomo-γ-linolenic acid (DGLA) is one of the 20-carbon fatty acids that can be metabolized to prostaglandins and thromboxanes (TXs) by cyclooxygenases 1 and 2 (COX-1/COX-2).1 The result of this metabolism in the human platelet yields TXB1. TXB1 is produced in small amounts when DGLA is added to washed suspensions of human platelets, while the major metabolism of this 1-series fatty acid is via 12-lipoxygenase.2 However, when co-incubated with amounts of ethanol often found in intoxicated humans, the metabolism of DGLA shifts to an enhanced production of TXB1.2 Urinary TXB1 or its metabolites may thus be a specific biomarker of prior ethanol abuse.

Definition

ChEBI: Thromboxane B1 is a thromboxane B that is thromboxane B2 in which the double bond at position 5-6 has been reduced to a single bond. It is a thromboxanes B and a monocarboxylic acid.

References

1. Levin, G., Duffin, K.L., Obukowicz, M.G., et al. Differential metabolism of dihomo-γ-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: Implications for cellular synthesis of prostaglandin E1 and prostaglandin E2 Biochem. J. 365(Pt 2),489-496(2002).
2. Manku, M.S., Oka, M., and Horrobin, D.F. Differential regulation of the formation of prostaglandins and related substances from arachidonic acid and from dihomogammalinolenic acid. I. Effects of ethanol Prostaglandins Med. 3(2),119-128(1979).

9ALPHA,11,15S-TRIHYDROXY-THROMBOX-13E-EN-1-OIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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9ALPHA,11,15S-TRIHYDROXY-THROMBOX-13E-EN-1-OIC ACID Suppliers

Shanghai Hongye Biotechnology Co. Ltd
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64626-32-0, 9ALPHA,11,15S-TRIHYDROXY-THROMBOX-13E-EN-1-OIC ACIDRelated Search:


  • 9ALPHA,11,15S-TRIHYDROXY-THROMBOX-13E-EN-1-OIC ACID
  • (13E,15S)-9α,11,15-Trihydroxythrombox-13-en-1-oic acid
  • TXB1
  • JSDWWNLTJCCSAV-VZBVYBAISA-N
  • THROMBOXANE B1
  • 2H-Pyran-3-heptanoic acid, tetrahydro-4,6-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]-, (2R,3S,4S)-
  • 64626-32-0