ChemicalBook > CAS DataBase List > 8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

Product Name
8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
CAS No.
510774-50-2
Chemical Name
8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
Synonyms
8-CPT-2'-O-ME CAMP NA;CAMP, 8-CPT-2'-O-ME, NA;-O-methyladenosine3’8CPT-2ME-CAMP, SODIUM SALT;-cyclicMonophosphateSodiumSalt;8-(4-Chlorophenylthio)-2’8-PCPT-2''-O-ME-CAMP SODIUM SALT;8-[(4-Chlorophenyl)thio]-2'-O-methyladenosine cyclic 3',5'-(hydrogen phosphate);8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT;8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic monophosphate sodium salt
CBNumber
CB1194975
Molecular Formula
C17H17ClN5O6PS
Formula Weight
485.84
MOL File
Mol file
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8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT Property

Boiling point:
748.9±70.0 °C(Predicted)
Density 
1.95±0.1 g/cm3(Predicted)
storage temp. 
Desiccate at -20°C
form 
White to off-white crystalline powder.
pka
0.92±0.60(Predicted)
Water Solubility 
water: 10mg/mL
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
1645
Product name
8-CPT-2Me-cAMP,sodiumsalt
Purity
≥99%(HPLC)
Packaging
1
Price
$195
Updated
2021/12/16
Biosynth Carbosynth
Product number
NC10431
Product name
8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic monophosphate sodium salt
Packaging
2mg
Price
$250
Updated
2021/12/16
Biosynth Carbosynth
Product number
NC10431
Product name
8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic monophosphate sodium salt
Packaging
5mg
Price
$525
Updated
2021/12/16
Biosynth Carbosynth
Product number
NC10431
Product name
8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic monophosphate sodium salt
Packaging
10mg
Price
$945
Updated
2021/12/16
Biosynth Carbosynth
Product number
NC10431
Product name
8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic monophosphate sodium salt
Packaging
25mg
Price
$1969
Updated
2021/12/16
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8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT Chemical Properties,Usage,Production

Uses

8-(4-Chlorophenylthio)-2''-O-methyladenosine 3'',5''-cyclic Monophosphate sodium salt is an activator of the Epac cAMP receptor. It can be used in biological study of interaction between TCL1 and Epac1 in activation of Akt kinases in plasma membranes and nuclei of 8-CPT-2-O-Me-cAMP-stimulated macrophages

Biological Activity

Selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC 50 = 2.2 mM), but not PKA (EC 50 > 10 mM). Stimulates Epac-mediated Ca 2+ -mediated Ca 2+ release in pancreatic b-cells in vitro .

in vivo

8-CPT-2'-O-Me-cAMP (2.05μM; 1 μL; intravitreal injection) inhibits development of choroidal neovascular lesions in a laser-injury model[1].

Animal Model:Wild type (WT) C57/Bl6 mice (choroidal neovascularization (CNV) model) [1]
Dosage:2.05μM; 1 μL
Administration:Intravitreal injection
Result:Induced a slight increase in F-actin localization to the cell periphery, and reorganized cell junctions to a more linear shape, dose-dependent decreased in CNV volume, increased Rap1 activity in isolated RPE/choroids.

8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT Suppliers

China 21 Switzerland 2 United Kingdom 2 United States 2 Global 27
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510774-50-2, 8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALTRelated Search:

Adenosine 3',5'-cyclic monophosphate sodium salt 2'-O-Methyladenosine

  • ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE, 8-(4-CHLOROPHENYLTHIO)-2'-O-METHYL-, SODIUM SALT
  • 8-PCPT-2''-O-ME-CAMP SODIUM SALT
  • 8CPT-2ME-CAMP, SODIUM SALT
  • 8-CPT-2'-O-ME CAMP NA
  • 8-(4-CHLOROPHENYLTHIO)-2',O-METHYLADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
  • CAMP, 8-CPT-2'-O-ME, NA
  • 8-[(4-Chlorophenyl)thio]-2'-O-methyladenosine cyclic 3',5'-(hydrogen phosphate)
  • Adenosine, 8-[(4-chlorophenyl)thio]-2'-O-methyl-, cyclic 3',5'-(hydrogen phosphate)
  • 8-(4-Chlorophenylthio)-2&rsquo
  • -cyclicMonophosphateSodiumSalt
  • -O-methyladenosine3&rsquo
  • 8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic monophosphate sodium salt
  • 510774-50-2
  • C17H16ClN5O6PSNa
  • C17H17ClN5O6PS