1,8-NAPHTHALALDEHYDIC ACID Property

Melting point:

160-167 °C

Boiling point:

441.2±18.0 °C(Predicted)

Density 

1.354±0.06 g/cm3(Predicted)

pka

2?+-.0.10(Predicted)

form 

Powder

color 

Cream

CAS DataBase Reference

5811-87-0

EPA Substance Registry System

8-Formyl-1-naphthalenecarboxylic acid (5811-87-0)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

HS Code 

29122900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

1,8-NAPHTHALALDEHYDIC ACID Chemical Properties,Usage,Production

Chemical Properties

Cream powder

Uses

1,8-Naphthalaldehydic acid may be used in the synthesis of fused bicyclic lactams, such as:

• 2,3,5,11b-tetrahydrobenz[de][1,3]oxazolo[3,2-a]isoquinolin-5-one
• 2,3,4,12b-tetrahydro-6H-benz[de][1,3]oxazino[3,2-a]isoquinolin-6-one
• 2,3,4,5,7,13b-hexahydrobenz[de][1,3]oxazepino[3,2-a]isoquinolin-7-one
• 1,2,3,11b-tetrahydro-5H-benz[de]imidazo[3,2-a]isoquinolin-5-one
• 1,2,3,4,6,12b-hexahydrobenzo[de]pyrimido[3,2-a]isoquinolin-7-one
• 1,2,3,4,5,13b-hexahydro-7H-benzo[de]1,3-diazepino[3,2-a]isoquinolin-7-one
• 7H-benzo[de]benzimidazo[3,2-a]isoquinolin-7-one
• 2,3,5,11b-tetrahydrobenzo[de]thiazolo[3,2-a]isoquinolin-5-one
• (9S,9R)-methyl 5-oxo[2,3,5,11b]-tetrahydrobenz[de]oxazolo[3,2-a]isoquinoline-3-carboxylate
• (3R,11bS)-3-phenyl-2,3,5,11b-tetrahydrobenz[de][1,3]oxazolo[2,3-a]isoquinolin-5-one

Synthesis Reference(s)

Journal of Medicinal Chemistry, 35, p. 823, 1992 DOI: 10.1021/jm00083a005