CEFADROXIL
- Product Name
- CEFADROXIL
- CAS No.
- 50370-12-2
- Chemical Name
- CEFADROXIL
- Synonyms
- cdx;duricef;Ultracef;cephadroxil;(6R,7R)-7-[[(R)-Amino(p-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;s-578;Roxil;Evacef;Neucef;NSC438
- CBNumber
- CB1203657
- Molecular Formula
- C16H17N3O5S
- Formula Weight
- 363.39
- MOL File
- 50370-12-2.mol
CEFADROXIL Property
- Melting point:
- 197°C (rough estimate)
- Boiling point:
- 238°C (rough estimate)
- Density
- 1.59
- refractive index
- 1.6390 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Water:9.17(Max Conc. mg/mL);25.23(Max Conc. mM)
- pka
- 3.12±0.50(Predicted)
- form
- powder or crystals
- InChIKey
- BOEGTKLJZSQCCD-UEKVPHQBSA-N
- CAS DataBase Reference
- 50370-12-2
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-42/43
- Safety Statements
- 26-36
- WGK Germany
- 2
- RTECS
- XI0337000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C7020
- Product name
- Cefadroxil
- Purity
- analytical standard
- Packaging
- 1g
- Price
- $61.4
- Updated
- 2024/03/01
- Product number
- C7020
- Product name
- Cefadroxil
- Purity
- analytical standard
- Packaging
- 5g
- Price
- $193
- Updated
- 2024/03/01
- Product number
- C235778
- Product name
- Cefadroxil
- Packaging
- 2.5g
- Price
- $115
- Updated
- 2021/12/16
- Product number
- J10293
- Product name
- Cefadroxil
- Packaging
- 100mg
- Price
- $37
- Updated
- 2021/12/16
- Product number
- CS-4696
- Product name
- Cefadroxil
- Purity
- 98.49%
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
CEFADROXIL Chemical Properties,Usage,Production
Description
Cephadroxil is an orally administered antibiotic, which is very similar to cephalexin. After oral administration, its peak serum level is slightly lower than that of cephalexin, but it is excreted more slowly. Therefore, it can be used for oral administration at 8- or 12-hourly intervals (Buck and Price, 1977; Pfeffer et al., 1977). Cephadroxil is still available in a number of European countries (for example, Spain, Belgium, Luxembourg, Portugal, and Finland, among others).
Chemical Properties
Cefadroxil is a light orange colored powder. It is a cephalosporin antibiotic and is used for the treatment of bacterial infections. Cefadroxil is stable under recommended storage conditions. Cefadroxil is not considered hazardous when handled under normal medical conditions and with good housekeeping
Originator
Oracefal,Bristol,France,1977
Uses
Antibacterial;Bacterial transpeptidase inhibitor
Definition
ChEBI: A cephalosporin bearing methyl and (2R)-2-amino-2-(4-hydroxyphenyl)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton.
Manufacturing Process
1.8 g of sodium N-(1-methoxycarbonyl-1-propen-2-yl)-D(-)-α-amino-(4-
hydroxyphenyl)acetate was suspended in 10 ml of acetone, and one droplet of
N-methylmorpholine was added thereto, and the mixture was cooled to -15°C.There was added 0.85 g of ethyl chlorocarbonate thereto, and the mixture
was reacted at -13°C to -10°C for 30 minutes, and then the reaction solution
was cooled to -20°C.
On the other hand, 1 g of 7-amino-3-methyl-3-cephem-4-carboxylic acid was
suspended in 20 ml of methanol, and 1.4 g of triethylamine was added
thereto to be dissolved, and 0.4 ml of acetic acid was further added thereto.
This solution was cooled to -20°C and the mixed acid anhydride prepared
previously was added thereto. After the mixture was reacted at -20°C for 1
hour, the temperature of the reaction mixture was raised to 0°C over a period
of 1 hour, and the mixture was reacted for 3 hours at the same temperature.
After the reaction, 1 ml of water was added to the reaction mixture, and the
mixture was adjusted to a pH of 1.0 with concentrated hydrochloric acid while
being cooled, and then stirred for 30 minutes, The insoluble matters were
filtered off, and the filtrate was adjusted to a pH of 5.5 with triethylamine.
This solution was concentrated under reduced pressure, and the residue was
diluted with 20 ml of acetone to precipitate white crystals. The crystals were
collected by filtration and washed with ethanol to obtain 1.46 g of white
crystals of 7-[D(-)-α-amino-(4-hydroxyphenyl)acetamido]-3-methyl-3-
cephem-4-carboxylic acid having a decomposition point of 197°C.
Therapeutic Function
Antibacterial
Health Hazard
Exposures to cefadroxil cause certain common side effects. These include nausea, vomiting, stomach disorders, rashes, itching, unusual tiredness or weakness, yellowing of the skin or eyes, red, swollen, or blistered skin, unusual bruising or bleeding, sore throat, respiratory distress, tightness in the chest, swelling of the mouth, face, lips, or tongue, decreased urination, dark urine, vaginal itching, odor, or discharge, fever, chills, joint pain, and seizures. Prolonged or long-term use of cefadroxil should be avoided.
Precautions
Cefadroxil should be used only under proper medical health care since it has properties of penicillin allergy, renal function, gastrointestinal tract damage. Pregnant women and breast-feeding women should avoid exposure to cefadroxil.
CEFADROXIL Preparation Products And Raw materials
Raw materials
Preparation Products
CEFADROXIL Suppliers
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14443
- Advantage
- 57
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12338
- Advantage
- 58
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7553
- Advantage
- 61
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4428
- Advantage
- 55
- Tel
- 021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7934
- Advantage
- 58
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3421
- Advantage
- 58
- Tel
- 15221275939 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 15878
- Advantage
- 55
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9767
- Advantage
- 58
- Tel
- 022-6537-8550 15522853686
- Fax
- 022-2532-9655
- sales@altasci.com.cn
- Country
- China
- ProdList
- 4515
- Advantage
- 55
- Tel
- 86 512-62572107 62962707
- Fax
- 86 512-62922078
- Country
- China
- ProdList
- 800
- Advantage
- 58
- Tel
- 020-61288194 61288195
- Fax
- 020-61288700
- 505721671@qq.com
- Country
- China
- ProdList
- 3868
- Advantage
- 58
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9934
- Advantage
- 55
- Tel
- 4009903999 13395398332
- Fax
- 0539-6365991
- sales@xiyashiji.com
- Country
- China
- ProdList
- 20810
- Advantage
- 60
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29797
- Advantage
- 68
- Tel
- 027-83991130 18627774460
- Fax
- 027-83991130
- 1718093273@QQ.COM
- Country
- China
- ProdList
- 1891
- Advantage
- 58
- Tel
- 0751-2886750 13927877953
- Fax
- 0751-2886750
- 3005811397@qq.com
- Country
- China
- ProdList
- 13360
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12308
- Advantage
- 58
- Tel
- 027-59402396 13419635609
- Fax
- 027-83989310
- 13419635609@163.com
- Country
- China
- ProdList
- 1993
- Advantage
- 55
- Tel
- 027-83778876 13667159345
- Fax
- 027-83778876
- 13667159345@163.com
- Country
- China
- ProdList
- 1941
- Advantage
- 55
- Tel
- 0539-6362799 20）
- Fax
- 0539-6362799（To 20）
- Country
- China
- ProdList
- 10007
- Advantage
- 58
- Tel
- 025-66113011 18112977050
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 16028
- Advantage
- 58
- Tel
- 027-83778895 18602735115
- Fax
- 027-51119224
- 18602735115@163.com
- Country
- China
- ProdList
- 1994
- Advantage
- 64
- Tel
- 020-81716320 17788709170
- Fax
- 020-81716319
- Sales@pipitech.com
- Country
- China
- ProdList
- 2649
- Advantage
- 58
- Tel
- 13382066392
- Country
- CHINA
- ProdList
- 4880
- Advantage
- 58
- Tel
- 400-400-400-9004166 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52712
- Advantage
- 58
- Tel
- +86-400-002-6226 13028896684
- sales@rrkchem.com
- Country
- China
- ProdList
- 55827
- Advantage
- 58
- Tel
- 0551-65418671
- Fax
- 0551-65418697
- sales@tnjchem.com
- Country
- China
- ProdList
- 34572
- Advantage
- 58
- Tel
- +8613367258412
- Fax
- 18062427325
- ada@ipurechemical.com
- Country
- China
- ProdList
- 10326
- Advantage
- 58
- Tel
- +86-18031140164 +86-19933155420
- erin@hbldbiotech.com
- Country
- China
- ProdList
- 878
- Advantage
- 58
- Tel
- +86-29-89586680 +86-15129568250
- 1026@dideu.com
- Country
- China
- ProdList
- 29016
- Advantage
- 58
- Tel
- +86-029-89586680 +86-18192503167
- Fax
- +86-29-88380327
- 1026@dideu.com
- Country
- China
- ProdList
- 9231
- Advantage
- 58
- Tel
- 86 18062405514 18062405514
- ada@ipurechemical.com
- Country
- CHINA
- ProdList
- 3465
- Advantage
- 58
- Tel
- +86-023-61398051 +8613650506873
- sales@chemdad.com
- Country
- China
- ProdList
- 39916
- Advantage
- 58
- Tel
- 027-59207796 13429867250
- Fax
- 027-59207796
- w13429867250@163.com
- Country
- China
- ProdList
- 1995
- Advantage
- 58
- Tel
- +8618523575427
- sales@conier.com
- Country
- China
- ProdList
- 49390
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- chenjw@absin.cn
- Country
- China
- ProdList
- 24734
- Advantage
- 58
- Tel
- 0185-0185-07139096 18507139096
- Fax
- QQ:1925957016
- 18507139096@163.com
- Country
- China
- ProdList
- 3855
- Advantage
- 58
- Tel
- 027-027-59212684 19107121455
- Fax
- QQ:2188308251
- p19107121455@163.com
- Country
- China
- ProdList
- 1797
- Advantage
- 58
- Tel
- 18501792038; 18501792038
- shanpel@anpel.com.cn
- Country
- China
- ProdList
- 9614
- Advantage
- 58
- Tel
- 0755-84826604
- 3001783715@qq.com
- Country
- CHINA
- ProdList
- 2898
- Advantage
- 58
- Tel
- 021-51111890 15317326293
- sales@molnova.com
- Country
- China
- ProdList
- 4196
- Advantage
- 58
- Tel
- 027-027-83984790 17720532645
- Fax
- 027-83984790
- t17720532645@163.com
- Country
- China
- ProdList
- 993
- Advantage
- 58
- Tel
- 0851-8475-2296 18096062265
- Fax
- 0851-84752205
- 646585516@qq.com
- Country
- China
- ProdList
- 2779
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44941
- Advantage
- 58
- Tel
- 400-880-2824 18107960669
- Fax
- 18140514863
- bd@ruiweier.cn
- Country
- China
- ProdList
- 1011
- Advantage
- 58
- Tel
- 020-36607679 13502246435
- sales@dmstandards.com
- Country
- China
- ProdList
- 10951
- Advantage
- 58
- Tel
- 021-50967598 02150967598
- sales@abmole.cn
- Country
- China
- ProdList
- 4495
- Advantage
- 58
- Tel
- 010-60605840 15801484223
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29834
- Advantage
- 58
- Tel
- 18902340307 18902340307
- Fax
- 0751-2819901
- 3356812514@qq.com
- Country
- China
- ProdList
- 9238
- Advantage
- 58
- Tel
- 029-81124267 15229202216
- Fax
- 029-88380327
- 1073@dideu.com
- Country
- China
- ProdList
- 10011
- Advantage
- 58
View Lastest Price from CEFADROXIL manufacturers
- Product
- Cefadroxil Monohydrate 50370-12-2
- Price
- US $0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2024-04-09
- Product
- CEFADROXIL 50370-12-2
- Price
- US $75.00-62.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 9000kg/per week
- Release date
- 2021-08-17
- Product
- Cefadroxil Capsule
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-01